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DRUG PROFILE
Year : 2011  |  Volume : 2  |  Issue : 2  |  Page : 111-119

Fumaric acid esters in dermatology


Department of Dermatology and Allergology, Hospital Dresden Friedrichstadt, Academic Teaching Hospital of the Technical University of Dresden, Dresden, Germany

Correspondence Address:
Uwe Wollina
Head of the Department of Dermatology and Allergology, Hospital Dresden Friedrichstadt, Academic Teaching Hospital of the Technical University of Dresden, Friedrichstrasse 41, 01067 Dresden
Germany
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Source of Support: None, Conflict of Interest: The author declares no conflict of interest or financial involvement with the company/companies manufacturing the drug. This is a review of a drug that has not yet entered the Indian market but will do so in the future as most other drugs.


DOI: 10.4103/2229-5178.86007

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Fumaric acid esters (FAE) are substances of interest in dermatology. FAE exert various activities on cutaneous cells and cytokine networks. So far only a mixture of dimethylfumarate (DMF) and three salts of monoethylfumarate (MEF) have gained approval for the oral treatment of moderate-to-severe plaque-type psoriasis in Germany. DMF seems to be the major active component. There is evidence that FAE are not only effective and safe in psoriasis but granulomatous non-infectious diseases like granuloma annulare, necrobiosis lipoidica and sarcoidosis. In vitro and animal studies suggest some activity in malignant melanoma as well.


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