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LETTER TO THE EDITOR
Year : 2013  |  Volume : 4  |  Issue : 1  |  Page : 61-62  

Detection of P53 and Mdm2 in vitiligo


Faculty of Medicine, University of Nis, Serbia, Hainan Medical University, China

Date of Web Publication3-Jan-2013

Correspondence Address:
Viroj Wiwanitkit
Wiwanitkit House, Bangkhae, Bangkok, Thailand

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2229-5178.105492

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How to cite this article:
Wiwanitkit V. Detection of P53 and Mdm2 in vitiligo. Indian Dermatol Online J 2013;4:61-2

How to cite this URL:
Wiwanitkit V. Detection of P53 and Mdm2 in vitiligo. Indian Dermatol Online J [serial online] 2013 [cited 2019 Dec 16];4:61-2. Available from: http://www.idoj.in/text.asp?2013/4/1/61/105492

Sir,

The recent report on detection of P53 and Mdm2 in vitiligo is very interesting. [1] Bakry et al. concluded that "The overexpression of P53 and Mdm2 proteins in both normally pigmented and depigmented skin of patients with vitiligo could contribute to the decreased occurrence of actinic damage and nonmelanoma skin cancer (NMSC) in these patients. [1] There are many concerns on this work. First, the use of non-equal matched case control design might imply some bias. Also, there is no exclusion for the other possible underlying conditions that can cause alteration of P53 and Mdm2. Second, the quality control of the immunohistochemistry is very important. The bias in scoring system can also be expected. Standardization of the technique is still the issue for further improvement. [2]

 
   References Top

1.Bakry OA, Hammam MA, Wahed MM. Immunohistochemical detection of P53 and Mdm2 in vitiligo. Indian Dermatol Online J 2012;3:171-6.  Back to cited text no. 1
[PUBMED]  Medknow Journal  
2.Yan D, Wang P, Knudsen BS, Linden M, Randolph TW. Statistical methods for tissue array images-Algorithmic scoring and co-training. Ann Appl Stat 2012;6:1280-305.  Back to cited text no. 2
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