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  Table of Contents  
CASES FROM ACKERMAN ACADEMY
Year : 2013  |  Volume : 4  |  Issue : 3  |  Page : 244-245  

Dermpath Quiz


1 Department of Dermatology, Elbe Klinikum Buxtehude, Buxtehude, Germany; Ackerman Academy of Dermatopathology, New York, USA
2 Ackerman Academy of Dermatopathology, New York, USA

Date of Web Publication24-Jul-2013

Correspondence Address:
Dirk Elston
145 East 32nd St 10th Floor, New York, USA

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2229-5178.115536

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How to cite this article:
Durda J, Kazlouskaya V, Blochin E, Maguire CA, Elston D. Dermpath Quiz. Indian Dermatol Online J 2013;4:244-5

How to cite this URL:
Durda J, Kazlouskaya V, Blochin E, Maguire CA, Elston D. Dermpath Quiz. Indian Dermatol Online J [serial online] 2013 [cited 2019 Dec 7];4:244-5. Available from: http://www.idoj.in/text.asp?2013/4/3/244/115536

A 35-year-old female patient with a several month history of a skin-colored nodule on the toe presented to the dermatology clinic. Clinically, the lesion was suggestive of a fibroma.

Histopathological sections showed a dermal tumor composed of stellate and spindle-shaped cells with fasciculated growth between collagen bundles and a myxoid stroma [Figure 1] and [Figure 2]. The deep portion of the lesion demonstrated a nodular growth pattern with some infiltration of surrounding collagen, myxoid stroma and mast cells. Immunohistochemical stains demonstrated diffuse strong expression of CD34 [Figure 3] and focal positivity for CD 99. Only scattered Factor XIIIa cells were present. S100 and EMA were negative.
Figure 1: Polypoid lesion of acral skin. [H & E stain, ×20]

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Figure 2: Fasciculated growth of spindle cells between collagen bundles in the superficial portion of the lesion. [H & E, ×400]

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Figure 3: Diffuse expression of CD34, magnification ×20

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The tumor most likely represents:

  1. Acquired digital fibrokeratoma
  2. Periungual fibroma
  3. Digital fibromyxoma
  4. Neurofibroma
  5. Inclusion body fibroma


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   References Top

1.Al-Daraji WI, Miettinen M. Superficial acral fibromyxoma: A clinicopathological analysis of 32 tumors including 4 in the heel. J Cutan Pathol 2008;35:1020-6.  Back to cited text no. 1
[PUBMED]    
2.Hollmann TJ, Bovée JV, Fletcher CD. Digital fibromyxoma (superficial acral fibromyxoma): A detailed characterization of 124 cases. Am J Surg Pathol 2012;36:789-98.  Back to cited text no. 2
    
3.Fetsch JF, Laskin WB, Miettinen M. Superficial acral fibromyxoma: A clinicopathologic and immunohistochemical analysis of 37 cases of a distinctive soft tissue tumor with a predilection for the fingers and toes. Hum Pathol 2001;32:704-14.  Back to cited text no. 3
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4.Prescott RJ, Husain EA, Abdellaoui A, Al-Mahmoud RM, Khan M, Salman WD, et al. Superficial acral fibromyxoma: A clinicopathological study of new 41 cases from the UK: Should myxoma (NOS) and fibroma (NOS) continue as part of 21st-century reporting? Br J Dermatol 2008;159:1315-21.   Back to cited text no. 4
[PUBMED]    
5.Fanti PA, Dika E, Piraccini BM, Infusino SD, Baraldi C, Misciali C. Superficial acral fibromyxoma: a clinicopathological and immunohistochemical analysis of 12 cases of a distinctive soft tissue tumor with a predilection for the fingers and toes. G Ital Dermatol Venereol 2011;146:283-7.  Back to cited text no. 5
[PUBMED]    
6.Ben Brahim E, Bouabdellah M, Khanchel F, Jouini R, Abdelmoula S, Chadli-Debbiche A. Superficial acral fibromyxoma. Tunis Med 2012;90:340-1.  Back to cited text no. 6
[PUBMED]    


    Figures

  [Figure 1], [Figure 2], [Figure 3]


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