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  Table of Contents  
LETTER TO THE EDITOR
Year : 2013  |  Volume : 4  |  Issue : 3  |  Page : 255-256  

Cutaneous angiomyolipoma


Department of Pathology, S. N. Medical College, Bagalkot, Karnataka, India

Date of Web Publication24-Jul-2013

Correspondence Address:
A S Ammanagi
Department of Pathology, USM-KLE International Medical Programme, School of Medical Science, Belgaum, Karnataka
India
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Source of Support: None, Conflict of Interest: None


PMID: 23984255

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How to cite this article:
Ammanagi A S, Dombale V D, Shindholimath V V. Cutaneous angiomyolipoma. Indian Dermatol Online J 2013;4:255-6

How to cite this URL:
Ammanagi A S, Dombale V D, Shindholimath V V. Cutaneous angiomyolipoma. Indian Dermatol Online J [serial online] 2013 [cited 2019 Dec 15];4:255-6. Available from: http://www.idoj.in/text.asp?2013/4/3/255/115543

Sir,

We are grateful for the careful review of our article by Okoń K et al. [1],[2] Although the triphasic nature of AML led us call this lesion "hamartoma," current clonality studies support their classification as neoplasms. Gill et al., defined angiomyolipoma as a benign clonal neoplasm composed of thick-walled blood vessels, smooth muscle cells, and adipose tissue, belonging to the family of perivascular epithelioid cell tumors (PEComa). [3] none However, AMLs are often referred to as hamartomas-a benign tumor-like growth composed of typical cells and tissues found in the area of the body where it occurs, but growing in an unorganized fashion. [4],[5]

We do not claim that the extrarenal AML constitutes a separated entity from renal AML, but it differs in sex predominance, clinical associations, circumscription, solitariness, and HMB-45 immunoreactivity. It is difficult to consider urachal remnant as a differential diagnosis in this case considering its clinical, gross, and microscopic findings. The diagnosis was offered considering its classical, triphasic, traditional, histological criteria. We agree with the reviewers that analysis of TSC1 and TSC2 genes would help in establishing the diagnosis. However, there are currently no data about their status in AML located in the skin.

 
   References Top

1.Ammanagi AS, Dombale VD, Shindholimath VV. Cutaneous angiomyolipoma. Indian Dermatol Online J 2012;3:40-1.  Back to cited text no. 1
[PUBMED]  Medknow Journal  
2.Okon K, Dyduch G. To the editor: Is this cutaneous angiomyolipoma truly an angiomyolipoma? Indian Dermatol Online J 2013;4:65.  Back to cited text no. 2
[PUBMED]  Medknow Journal  
3.Gill S, Edit WS, Chen F. A review of angiomyolipoma and its morphological variants. N A J Med Sci 2011;4:84-8.  Back to cited text no. 3
    
4.Minja EJ, Pellerin M, Saviano N, Chamberlain RS. Retroperitoneal extrarenal angiomyolipomas: An evidence-based approach to a rare clinical entity. Case Rep Nephrol 2012;2012:7.  Back to cited text no. 4
    
5.Lee CH, Kim JH, Yang DH, Hwang Y, Kang MJ, Kim YK, et al. Ileal angiomyolipoma manifested by small intestinal intussusception. World J Gastroenterol 2009;15:1398-400.  Back to cited text no. 5
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