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Year : 2013  |  Volume : 4  |  Issue : 4  |  Page : 376-377  

Nevus lipomatosus cutaneous superficialis

Department of Dermatology, L.T.M. Medical College and General Hospital, Mumbai, Maharashtra, India

Date of Web Publication28-Oct-2013

Correspondence Address:
Ganesh Avhad
Department of Dermatology, Room No 304, New RMO Hostel, L.T.M. Medical College and General Hospital, Sion, Mumbai - 400 022
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2229-5178.120660

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How to cite this article:
Avhad G, Jerajani H. Nevus lipomatosus cutaneous superficialis. Indian Dermatol Online J 2013;4:376-7

How to cite this URL:
Avhad G, Jerajani H. Nevus lipomatosus cutaneous superficialis. Indian Dermatol Online J [serial online] 2013 [cited 2020 Aug 12];4:376-7. Available from: http://www.idoj.in/text.asp?2013/4/4/376/120660

A 19-year-old male presented with asymptomatic, skin-colored mass (25 × 15 cm) on the lower back since birth [Figure 1]. The patient gave history of increase in the size of the mass over a period of time. Similar lesion was present over his left foot [Figure 2]. No history of similar lesion was present in the family members. Histopathology showed groups and strands of fat cells embedded in the collagen bundles of the mid or lower dermis [Figure 3].
Figure 1: Clustered group of soft, fleshy, skin-colored to yellow nodules with smooth, wrinkled, cerebriform appearance over lower back

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Figure 2: Skin-colored nodules with smooth surface over left foot

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Figure 3: Hematoxylin and eosin stain showed ectopic fat cells in the dermis (H and E, ×100)

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Nevus lipomatosus cutaneous superficialis (NCLS) is a rare hamartoma of adipose tissue. It is divided into classical form and solitary form. It usually presents as a clustered group of soft, fleshy, skin-colored or yellowish nodules, which are either sessile or pedunculated growths with a smooth, wrinkled or cerebriform surface. [1] The most common sites are pelvic girdle, buttocks, back or abdomen. They are usually present at birth or emerge during the first two decades of life. [2] It was first reported by Hoffmann and Zurhelle in 1921. [3]

Histopathologically, it is characterized by the presence of ectopic mature fat in the dermis mostly around the perivascular area and varies from 10% to 50% of the lesion. Epidermis may show acanthosis, basket weave hyperkeratosis, rete ridges obliteration with focal elongation, and increased basal pigmentation. There may be increased density of the collagen fibers, number of fibroblast with decreased elastic tissue along with perivascular mononuclear cell, and spindle-shaped cell infiltration in the dermis. [4] Electron microscopy has shown that lipocytes are closely associated with capillaries, and it has been suggested that they may originate from pericytes. [5] Recently a 2p24 deletion was found in nevus lipomatosis superficialis. [6]

There are reports showing its co-localization with lipedematous scalp [7] and Michelin tire baby [8] appearance. The closest differential diagnosis of solitary form is segmental neurofibromatosis. [9]

Wide excision with skin grafting remains the treatment of choice.

   References Top

1.Yap FB. Nevus lipomatosus superficialis. Singapore Med J 2009;50:e161-2.  Back to cited text no. 1
2.Khandpur S, Nagpal SA, Chandra S, Sharma VK, Kaushal S, Safaya R. Giant nevus lipomatosus cutaneous superficialis. Indian J Dermatol Venereol Leprol 2009;75:407-8.  Back to cited text no. 2
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3.Hoffmann E, Zurhelle E. UBER einen Naevus lipomatodes cutaneaous superficialis der linken Glutaalgegend. Arch Dermatol Syphilol 1921;130:327.  Back to cited text no. 3
4.Umashankar T, Prasad T, Rajeshwari SH. Naevus lipomatosus superficialis: Clinicopathological study of a case. Indian J Pathol Microbiol 2003;46:444-5.  Back to cited text no. 4
5.Dotz W, Prioleau PG. Nevus lipomatosus cutaneus superficialis. A light and electron microscopic study. Arch Dermatol 1984;120:376-9.  Back to cited text no. 5
6.Cardot-Leccia N, Italiano A, Monteil MC, Basc E, Perrin C, Pedeutour F. Naevus lipomatosus superficialis: A case report with a 2p24 deletion. Br J Dermatol 2007;156:380-1.  Back to cited text no. 6
7.Mansur AT, Yasar S, Aydingöz IE, Göktay F, Ozdemir N, Sungurlu F. Colocalization of lipedematous scalp and nevus lipomatosus superficialis: A case report. J Cutan Pathol 2007;34:342-5.  Back to cited text no. 7
8.Palit A, Inamadar AC. Circumferential skin folds in a child : a0 case of Michelin tire baby syndrome. Indian J Dermatol Venereol Leprol 2007;73:49-51.  Back to cited text no. 8
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9.Armstrong DK, Walsh MY, Bingham A, McMillan C. Naevus lipomatosus cutaneous superficialis. Australas J Dermatol 1997;38:88-90.  Back to cited text no. 9


  [Figure 1], [Figure 2], [Figure 3]

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