• Users Online: 1127
  • Print this page
  • Email this page


 
  Table of Contents  
ORIGINAL ARTICLE
Year : 2014  |  Volume : 5  |  Issue : 3  |  Page : 287-290  

Evaluation of intralesional 5% 5-fluorouracil in resistant localized plaque psoriasis


Department of Dermatology, Guru Gobind Singh Medical College and Hospital, Faridkot, Punjab, India

Date of Web Publication31-Jul-2014

Correspondence Address:
Monika Singla
Department of Dermatology, Guru Gobind Singh Medical College and Hospital, Sadiq Road, Faridkot - 651 203, Punjab
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2229-5178.137779

Rights and Permissions
   Abstract 

Background: Psoriasis is a chronic, autoimmune, inflammatory papulosquamous disorder, the treatment of which remains challenging. A variety of therapeutic modalities have been used with varying degree of success. But, there is no such therapeutic modality till date that can prevent the relapse in psoriasis. Aims: The present study is being undertaken to evaluate the therapeutic efficacy of intralesional 5% 5-fluorouracil (5-FU) as well as its role in preventing relapse in resistant localized plaque psoriasis. Study Design: An open, prospective, randomized-controlled study. Materials and Methods: A total of 40 patients of resistant localized plaque psoriasis were enrolled for the study. Intralesional injection of 5% 5-FU was given in a dosage of 0.1 mL/cm 2 of each plaque using an insulin syringe. In all patients, a single plaque was kept as control and was given intralesional injection of distilled water. A total of three injections were given in each plaque at weekly intervals. After that, patients were followed-up regularly at the interval of 2 weeks up to 12 weeks. All the lesions (both treated and control) were assessed clinically as well as photographically at each visit and graded using psoriasis severity index scoring. Results were analyzed statistically at the end of the follow-up period. Results: At 12 weeks follow-up, out of 40 patients treated, 4 (10%) patients had clearance (>90% resolution), 19 (47.5%) had excellent (70%-90%) improvement, whereas 12 (30%) patients were moderately (30%-70%) improved, and only 5 (12.5%) patients had mild or no improvement. Results were statistically significant in treated group in comparison to control group. Almost all patients complained of pain at the site of injection which subsided within 1-2 h. A total of 10 (25%) patients had necrosis after one or two injections which healed during the follow-up period within 6-8 weeks. Conclusion: Intralesional 5% 5-FU is found to be an effective therapeutic modality in resistant localized plaque psoriasis without much side effects.

Keywords: 5-fluorouracil, intralesional, plaque psoriasis


How to cite this article:
Mahajan BB, Singla M. Evaluation of intralesional 5% 5-fluorouracil in resistant localized plaque psoriasis . Indian Dermatol Online J 2014;5:287-90

How to cite this URL:
Mahajan BB, Singla M. Evaluation of intralesional 5% 5-fluorouracil in resistant localized plaque psoriasis . Indian Dermatol Online J [serial online] 2014 [cited 2019 Dec 16];5:287-90. Available from: http://www.idoj.in/text.asp?2014/5/3/287/137779


   Introduction Top


Psoriasis is a recurrent and progressive papulosquamous disorder that causes significant social and psychological trauma to the patient. It is characterized by the presence of erythematous, sharply demarcated, indurated plaques covered with silvery-white scales. It is a commonly encountered inflammatory disorder with an estimated global prevalence ranging from 0.5% to 4.6%.[1] There is no cure for psoriasis, but there are a variety of treatment modalities that can help improve symptoms and quality of life. A number of studies show that intralesional 5% 5-fluorouracil (5-FU) is an effective modality in various benign, premalignant and malignant cutaneous diseases.

5-FU is an antimetabolite that inhibits deoxyribonucleic acid synthesis as well as ribonucleic acid processing and therefore decreases epidermal proliferation. [2] It has been widely used topically, intravenously, and intralesionally in various dermatological and nondermatological diseases. It is available as a solution, cream and as sustained-release preparation for intralesional use in various concentrations (0.5%, 1%, and 5%). This study was done to evaluate the therapeutic efficacy of intralesional 5% 5-FU as well as its role in preventing relapse in resistant localized plaque psoriasis.


   Materials and methods Top


We performed an open, prospective, randomized, placebo-controlled study enrolling 40 patients of localized plaque psoriasis attending the outpatient clinic in the department of dermatology at GGS Medical College and Hospital, Faridkot. Patients with generalized psoriasis, in the pediatric or elderly age group, pregnant and lactating females, and patients with known hypersensitivity to 5-FU were excluded from the study.

Patients were diagnosed clinically and a written informed consent was taken from each patient before starting the study. A detailed history and general examination including mucocutaneous examination was conducted in each case. All the routine investigations including complete hemogram, serum biochemical profile, blood sugar, and urinalysis were done for each patient.

Taking all aseptic precautions, 5% 5-FU was infiltrated under the lesion in a dosage of 0.1 mL/cm 2 of the plaque using an insulin syringe. A smaller lesion was injected from a single puncture site but a larger lesion was injected from multiple sites. The total dose of 5-FU did not exceed 150 mg at single sitting. One plaque was selected for intralesional injection of distilled water as control in all patients. Each patient was kept under observation for the next 10-15 min to detect immediate complications like pain, edema, and erythema. Each patient was also observed after 24 h to detect any untoward side effects like persistent pain, sensitivity to 5-FU, or any signs of necrosis.

Intralesional injection of 5% 5-FU was given weekly for a total of three injections. After that patients were followed-up regularly at intervals of 2 weeks up to 12 weeks. All the lesions injected with 5% 5-FU as well as distilled water were assessed clinically as well as photographically at the baseline, at each visit before the administration of intralesional injection and at each follow-up visit. Psoriasis severity index (PSI) of treated plaques was calculated at each visit which is the summation of erythema, induration, and scale points and ranges between 0 and 12 [Table 1].
Table 1: Psoriasis severity index

Click here to view


The response to treatment taking into consideration erythema, induration, and scaling was graded as shown in [Table 2].
Table 2: Grades of improvement evaluated by PSI scores

Click here to view


Results were analyzed statistically after completion of the follow-up period.


   Results Top


In this study, the age of patients ranged between 20 and 60 years (mean age 39.55 ± 11.26 years); 31 were males (77.5%) and 9 were females (22.5%). The duration of the disease ranged from 1.5 months to 15 years (majority between 1 and 5 years).

After three injections of 5-FU, 57.5% (23/40) patients showed excellent (70%-90%) improvement, 30% (12) patients had moderate (30%-70%) improvement, and only 5 (12.5%) patients did not respond to treatment. At the end of follow-up period of 10 weeks after last injection (12 th week), 4 (10%) patients had clearance (>90% resolution), 19 (47.5%) had excellent improvement, whereas 12 (30%) patients were moderately improved; only 5 (12.5%) patients had mild or no improvement. This is in contrast to control plaques in which 27 (67.5%) patients had mild or no improvement [Figure 1]. Clinical photographs of improvement in psoriatic plaques treated with intralesional 5% 5-FU as well as control plaque (treated with distilled water) are shown in [Figure 2], [Figure 3], [Figure 4]. These differences were statistically significant ( P value <.001). Most of the patients remained in remission or improved further during follow-up period. Only two patients relapsed with significant increase in PSI scoring which had impact on the grading of improvement from excellent to moderate category.
Figure 1: Comparison of grades of improvement between plaques treated with intralesional 5% 5-fluorouracil and kept as control after 12 weeks

Click here to view
Figure 2: (a) Psoriatic plaques on right elbow before injection at day 0. (b) Psoriatic plaques on left elbow kept as control. (c) Plaques showing improvement after three 5-FU injections after 12 weeks. (d) Control plaques after 12 weeks

Click here to view
Figure 3: (a) A psoriatic plaque on left leg before injection. (b) The same plaque after three injections after 12 weeks (showing significant improvement)

Click here to view
Figure 4: (a) A psoriatic plaque on leg at day 0. (b) The same plaque after three injections of 5- FU after 12 weeks

Click here to view


No clinically significant systemic side effects or treatment-related adverse medical events were observed in our study. Most patients found the injections to be painful. A total of eight (20%) patients developed necrosis in at least one plaque after one injection of 5% 5-FU within 24 h, whereas two (5%) patients developed necrosis after two injections. Necrosis gradually healed within 2-4 weeks leaving hyperpigmentation in all patients and scarring in two patients. Hyperpigmentation was seen in 37 (92.5%) patients after treatment period which gradually disappeared within 8-10 weeks.


   Discussion Top


Psoriasis has become a major psychosocial problem today with cosmetic concern, for which no definite cure is available. Treatment of psoriasis aims to achieve clearing of the psoriatic lesions and preventing their recurrence. During last few years, various new medical and surgical treatments including phototherapy and lasers have been tried. 5-FU is a fluorinated pyrimidine analogue which emerged as a new class of antimetabolite drug in 1957. [3] 5-FU is indicated in various dermatological diseases as both topical as well as intralesional agent. The advantage of intralesional 5-FU is that it allows higher drug concentration in the lesion for longer duration in comparison to topical 5-FU.

Intralesional 5% 5-FU has been effectively used in various dermatological diseases like keratoacanthomas, basal cell carcinoma, hypertrophic scars, keloids, warts, infantile digital fibromatosis, and psoriasis. [4],[5],[6],[7],[8],[9],[10],[11],[12],[13],[14],[15],[16],[17] In our study, the response rate was 87.5% (10% patients with clearance, 47.5% with excellent improvement, and 30% moderate improvement). The results in our study are comparable with a study done by Pearlman et al.,[15] which showed favorable response in 82% patients of psoriasis treated with intralesional 5% 5-FU. Similar results were observed in a study by Taheri et al.,[17] (70%-90% improvement in 61% patients and > 90% improvement in 33.3% patients).

In our study, there were only local side effects such as pain, necrosis, and hyperpigmentation. These are similar to previous studies related to intralesional 5-FU in which no systemic adverse events were observed. [4],[5],[6],[7],[8],[9],[10],[11],[12],[13],[14],[15],[16],[17]


   Conclusion Top


From the results of the above study, it may be concluded that intralesional 5% 5-FU is an effective therapeutic modality not only for treatment but also for preventing relapse in localized plaque psoriasis. Further studies with a larger sample size and extended follow-up would be beneficial to delineate the clinical role and duration of remission with intralesional 5% 5-FU in patients of localized plaque psoriasis.

 
   References Top

1.Lebwohl M. Psoriasis. Lancet 2003;361:1197-204.  Back to cited text no. 1
[PUBMED]    
2.Longley DB, Harkin DP, Johnston PG. 5-fluorouracil: Mechanisms of action and clinical strategies. Nat Rev Cancer 2003;3:330-8.  Back to cited text no. 2
    
3.Heidelberger C, Chaudhuri NK, Danneberg P, Mooren D, Griesbach L, Duschinsky R, et al. Fluorinated pyrimidines, a new class of tumor-inhibitory compounds. Nature 1957;179:663-6.  Back to cited text no. 3
[PUBMED]    
4.Goette DK, Odom RB. Successful treatment of keratoacanthoma with intralesional fluorouracil. J Am Acad Dermatol 1980;2:212-6.  Back to cited text no. 4
[PUBMED]    
5.Bergin DJ, Lapins NA, Deffer TA. Intralesional 5-fluorouracil for keratoacanthoma of the eyelid. Ophthal Plast Reconstr Surg 1986;2:201-4.  Back to cited text no. 5
    
6.Miller BH, Shavin JS, Cognetta A, Taylor JR, Salasche S, Korey A, et al. Non-surgical treatment of basal cell carcinomas with intralesional 5-fluorouracil/epinephrine injectable gel. J Am Acad Dermatol 1997;36:72-7.  Back to cited text no. 6
    
7.Gupta S, Kalra A. Efficacy and safety of intralesional 5-fluorouracil in the treatment of keloids. Dermatology 2002;204:130-2.  Back to cited text no. 7
    
8.Fitzpatrick RE. Treatment of inflamed hypertrophic scars using intralesional 5-FU. Dermatol Surg 1999;25:224-32.  Back to cited text no. 8
[PUBMED]    
9.Apikian M, Goodman G. Intralesional 5-fluorouracil in the treatment of keloid scars. Australas J Dermatol 2004;45:140-3.  Back to cited text no. 9
    
10.Kontochristopoulos G, Stefanaki C, Panagiotopoulos A, Stefanaki K, Argyrakos T, Petridis A, et al. Intralesional 5-fluorouracil in the treatment of keloids: An open clinical and histopathological study. J Am Acad Dermatol 2005;52 (3 Pt 1):474-9.  Back to cited text no. 10
    
11.Darougheh A, Asilian A, Shariati F. Intralesional triamcinolone alone or in combination with 5-fluorouracil for the treatment of keloid and hypertrophic scars. Clin Exp Dermatol 2009;34:219-23.  Back to cited text no. 11
    
12.Iscimen A, Aydemir EH, Goksugur N, Engin B. Intralesional 5-fluorouracil, lidocaine and epinephrine mixture for the treatment of verrucae: A prospective placebo-controlled, single-blind randomized study. J Eur Acad Dermatol Venereol 2004;18:455-8.  Back to cited text no. 12
    
13.Yazdanafar A, Farshchian M, Fereydoonnejad M, Farshchian M. Treatment of common warts with an intralesional mixture of 5-fluorouracil, lidocaine and epinephrine: A prospective placebo-controlled, double-blind randomized trial. Dermatol Surg 2008;34:656-9.  Back to cited text no. 13
    
14.Oh CK, Son HS, Kwon YW, Jang HS, Kwon KS. Intralesional fluorouracil injection in infantile digital fibromatosis. Arch Dermatol 2005;141:549-50.  Back to cited text no. 14
    
15.Pearlman DL, Youngberg B, Engelhard C. Weekly psoriasis therapy using intralesional fluorouracil. J Am Acad Dermatol 1987;17:78-82.  Back to cited text no. 15
[PUBMED]    
16.Lowe NJ, Nychay S, Oreberg SK, Koray A. Intradermal fluorouracil and epinephrine injectable gel for treatment of psoriatic plaques. Arch Dermatol 1995;131:1340-1.  Back to cited text no. 16
    
17.Taheri S, Asilian A, Faghihi G. Efficacy of 5-fluorouracil plus epinephrine, Pulsed dye laser and Betamethasone on the improvement of psoriatic plaques (a comparative study). Iranian J Dermatol 2009;12:36-41.  Back to cited text no. 17
    


    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4]
 
 
    Tables

  [Table 1], [Table 2]


This article has been cited by
1 Clearance and hyperpigmentation of chronic psoriatic plaques by tegafur/gimercil/oteracil potassium (TS-1)
Kozo Nakai,Junko Moriue,Emiko Ishikawa,Ayako Nishiura,Tetsuya Moriue,Yasuo Kubota
Dermatologica Sinica. 2017;
[Pubmed] | [DOI]
2 5-Fluorouracil shell-enriched solid lipid nanoparticles (SLN) for effective skin carcinoma treatment
Rasha A. Khallaf,Heba F. Salem,Ahmed Abdelbary
Drug Delivery. 2016; 23(9): 3452
[Pubmed] | [DOI]
3 The effect of topical 5-flurouracil application post endoscopic inferior turbinoplasty
Amjad F. Nuseir,Mohammad Alsalem,Mouhamad Alzahr,Muthanna Ababneh,Ahmad I. Alomari,Firas Alzoubi
American Journal of Otolaryngology. 2016;
[Pubmed] | [DOI]



 

Top
 
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
    Abstract
   Introduction
    Materials and me...
   Results
   Discussion
   Conclusion
    References
    Article Figures
    Article Tables

 Article Access Statistics
    Viewed3560    
    Printed31    
    Emailed0    
    PDF Downloaded277    
    Comments [Add]    
    Cited by others 3    

Recommend this journal