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ORIGINAL ARTICLE
Year : 2014  |  Volume : 5  |  Issue : 4  |  Page : 456-460

Increased prevalence of thyroid dysfunction and diabetes mellitus in Indian vitiligo patients: A case-control study


1 Department of Dermatology, Maharajah's Institute of Medical Sciences, Nellimarla, Vizianagaram District, Andhra Pradesh, India
2 Department of Dermatology, Surya Skin Care and Research Center, Visakhapatnam, Andhra Pradesh, India
3 Department of Dermatology, MVJ Medical College, Bengaluru, Karnataka, India

Correspondence Address:
K.V.T. Gopal
4-69-19, Opp. Shanti Ashram Street, Lawsons Bay Colony, Visakhapatnam - 530 017, Andhra Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2229-5178.142493

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Background: Though it is well-known that vitiligo is associated with other autoimmune disorders, few Indian studies have focused on the relation between vitiligo, autoimmune thyroid dysfunction and diabetes mellitus. Materials and Methods: This case-control study included 150 new cases of vitiligo and 100 age and sex-matched controls. A complete history and thorough dermatological examination was done. Serum samples from both patients and controls were collected and assayed for triiodothyronine, thyroxine, thyroid-stimulating hormone, anti-thyroid antibodies-anti-thyroid peroxidase and anti-thyroglobulin and fasting plasma glucose. Results: Thyroid hormonal profile revealed autoimmune thyroid dysfunction manifesting as hypothyroidism in 30 (20%) vitiligo patients and two controls (2%). Diabetes mellitus was present in 24 (16%) vitiligo patients and five controls. Seven (4.7%) patients had both hypothyroidism and diabetes mellitus. Conclusion: There is a clear association between vitiligo, autoimmune hypothyroidism and diabetes mellitus. It would be very useful to screen for thyroid dysfunction and diabetes mellitus in all patients with vitiligo.


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