• Users Online: 1350
  • Print this page
  • Email this page


 
  Table of Contents  
LETTER TO THE EDITOR
Year : 2015  |  Volume : 6  |  Issue : 1  |  Page : 52-54  

Norwegian scabies: Rare cause of erythroderma


1 Department of Dermatology, Medical College and Hospital, Kolkata, West Bengal, India
2 Department of Dermatology, Midnapore Medical College and Hospital, Midnapore, West Bengal, India
3 Department of Dermatology, Bankura Sammilani Medical College, Bankura, West Bengal, India

Date of Web Publication8-Jan-2015

Correspondence Address:
Dr. Anirban Das
Department of Dermatology, Medical College and Hospital, 88, College Street, Kolkata - 700 073, West Bengal
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2229-5178.148951

Rights and Permissions

How to cite this article:
Das A, Bar C, Patra A. Norwegian scabies: Rare cause of erythroderma. Indian Dermatol Online J 2015;6:52-4

How to cite this URL:
Das A, Bar C, Patra A. Norwegian scabies: Rare cause of erythroderma. Indian Dermatol Online J [serial online] 2015 [cited 2019 Dec 7];6:52-4. Available from: http://www.idoj.in/text.asp?2015/6/1/52/148951

Sir,

Erythroderma is the condition where more than 90% body surface area develops erythema and scaling. Common causes are eczemas (40%), psoriasis (15%), drugs and malignancy, while crusted scabies, lichen planus, dermatomyositis, etc. account for only 0.5% cases. [1],[2]

Scabies is an infestation by ectoparasite of female gravid mite of Sarcoptes scabiei var. hominis. Burrow is the pathognomonic feature of scabies infestation. The average number of adult female mites on an individual suffering from the common form of scabies is about 12. Approximately 40-50 eggs are laid by each female during its lifespan of 4-6 weeks, during which time she doesn't leave the burrow. Scabies affects all races and social classes worldwide, but accurate figures of its prevalence are difficult to obtain. [1]

The appellation "Norwegian" derives from the description in Norway by Danielssen and Boeck of a type of scabies in which a huge number of mites were present in lepers may be the number of mites was in millions. It is seen in patients with sensory anesthesia, mental impairment, physical incapacity, and immunosuppression. [1]

A 62-year-old patient presented with large, warty crusts with irregular thickening and fissuring of the scalp, neck, trunk, arms, forearms, thighs, genitalia, gluteal region, dorsum of hands and webs of fingers [Figure 1], [Figure 2] and [Figure 3]. Scaling was generalized and there was sparing of palms, soles, and nails. There was no itching at the time of presentation. He developed mild itching on some occasions during the course of illness and over one a period of year, he had been treated in multiple hospitals for eczema and psoriasis and applied topical corticosteroid for his hyperkeratotic lesions [Figure 4]. On general examination, he had pallor and generalized lymphadenopathy. On dermatological examination, large thickened crusts were evident from the scalp to mid-thigh, sparing some areas of the chest, palms, soles and nails. More than 90% of skin surface was involved with erythema and scaling. Crusts could be separated with a forceps without bleeding. On mental state examination, patient had dementia and denied sensation of itching. Microscopic examination of crusts dissolved in 10% KOH revealed fields teeming with mites and eggs [Figure 5] and [Figure 6]. He was treated with ivermectin 12 mg weekly for four weeks and application of topical permethrin 5% cream every day for two weeks and then once weekly for the next two weeks. After one month of treatment the patient's erythroderma and skin lesions regressed completely.
Figure 1: Generalized scaling all over the body

Click here to view
Figure 2: Scaling over back and buttocks

Click here to view
Figure 3: Affection of web of fingers and dorsum of hand and forearms

Click here to view
Figure 4: Scaling over the neck

Click here to view
Figure 5: Scabies mite in KOH mount of scales (×10)

Click here to view
Figure 6: Eggs of scabies mite in 10% KOH mount

Click here to view


In common scabies, there are few mites, probably because scratching destroys the burrows. A good standard of hygiene may also help to control the mite population. In crusted scabies, the host's response to the mites is modified, allowing them to multiply. [1],[3] Patients who are mentally retarded or suffer from dementia may develop crusted scabies. [2] The reason for this association with mental abnormality is not completely understood, but lack of appreciation of pruritus may be important. Crusted scabies has also resulted from inappropriate use of potent topical steroids. [3],[4],[5],[6] Suppression of sensitivity to the mites reduces itching, so there is less scratching and destruction of burrows. Moreover, diagnosis of the cause of erythroderma is sometimes difficult and repeated biopsy is needed.

Our clinical differential diagnoses were hyperkeratotic eczema, psoriasis, contact dermatitis, but after application of topical corticosteroid the lesions didn't resolve but rather they were exacerbated. There were crusts; and no micaceous scales or the Auspitz's sign of were absent. Thus the patient's dementia likely contributed to scabies evolving into the crusted variant while the use of topical potent corticosteroid exacerbated the erythroderma.

 
   References Top

1.
Burns DA. Diseases caused by arthropods and other noxious animals. In: Burns T, Breathnach S, Cox N, Griffiths C, editors. Rook's Textbook of Dermatology. 8 th ed. Oxford: Wiley-Blackwell; 2010. p. 38.40-4.  Back to cited text no. 1
    
2.
Berth-Jones J. Eczema, lichenification, prurigo and erythroderma. In: Burns T, Breathnach S, Cox N, Griffiths C, editors. Rook's Textbook of Dermatology. 8 th ed. Oxford: Wiley-Blackwell; 2010. p. 23.46-9.  Back to cited text no. 2
    
3.
Herridge CF. Norwegian scabies (crusted scabies). Br Med J 1963;1:239-40.  Back to cited text no. 3
[PUBMED]    
4.
Clayton R, Farrow S. Norwegian scabies following topical steroid therapy. Postgrad Med J 1975;51:657-9.  Back to cited text no. 4
[PUBMED]    
5.
Macmillan AL. Unusual features of scabies associated with topical fluorinated steroids. Br J Dermatol 1972;87:496-7.  Back to cited text no. 5
[PUBMED]    
6.
Millard LG. Norwegian scabies developing during treatment with fluorinated steroid therapy. Acta Derm Venereol 1977;57:86-8.  Back to cited text no. 6
[PUBMED]    


    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5], [Figure 6]


This article has been cited by
1 Eritrodermia en el adulto: un enfoque práctico para el diagnóstico y tratamiento
A. Cuellar-Barboza,J. Ocampo-Candiani,M.E. Herz-Ruelas
Actas Dermo-Sifiliográficas. 2018;
[Pubmed] | [DOI]
2 Cutaneous histoplasmosis with prominent parasitization of epidermal keratinocytes: report of a case
Hedieh H. Honarpisheh,Jonathan L. Curry,Kristen Richards,Priyadharsini Nagarajan,Phyu P. Aung,Carlos A. Torres-Cabala,Doina Ivan,Carol R. Drucker,Richard Cartun,Victor G. Prieto,Michael T. Tetzlaff
Journal of Cutaneous Pathology. 2016;
[Pubmed] | [DOI]
3 Norwegian scabies - rare case of atypical manifestation
Karina Corrêa Ebrahim,Júlia Barazetti Alves,Lísias de Araújo Tomé,Carlos Floriano de Moraes,Arianne Ditzel Gaspar,Karin Fernanda Franck,Mohamad Ali Hussein,Lucas Raiser da Cruz,Leonardo Duque Ebrahim,Luis Felipe de Oliveira Sidney
Anais Brasileiros de Dermatologia. 2016; 91(6): 826
[Pubmed] | [DOI]
4 Contagious Erythroderma
Xiang-Dong Wang,Hong Shen,Ze-Hu Liu
The Journal of Emergency Medicine. 2016;
[Pubmed] | [DOI]



 

Top
 
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
    References
    Article Figures

 Article Access Statistics
    Viewed2913    
    Printed31    
    Emailed0    
    PDF Downloaded325    
    Comments [Add]    
    Cited by others 4    

Recommend this journal