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CASE REPORT
Year : 2015  |  Volume : 6  |  Issue : 3  |  Page : 207-209

Ineffectiveness of tumor necrosis factor-α blockers and ustekinumab in a case of type IV pityriasis rubra pilaris


1 Department of Internal Medicine and Medical Specialities, Dermatology Unit, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy
2 Department of Internal Medicine and Medical Specialities, Pathology Unit, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy

Correspondence Address:
Dr. Vito Di Lernia
Dermatology Unit, Arcispedale Santa Maria Nuova-IRCCS, Viale Risorgimento 68, 42123 Reggio Emilia
Italy
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2229-5178.156410

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Treatment of pityriasis rubra pilaris (PRP) may be difficult since no standardized therapeutic approach has been established. Recently, tumor necrosis factor-α (TNF-α) blockers have been demonstrated to be favorable in the management of recalcitrant PRP. The authors report a case of a patient who presented a type IV PRP or circumscribed, juvenile type. Such a condition follows an unpredictable course, presenting with diffuse, palmoplantar keratoderma and sharply-demarcated areas of follicular hyperkeratosis on the elbows and knees. Treatment with all available TNF-α inhibitors and ustekinumab did not prove to be helpful. The authors suggest that circumscribed variants of PRP could respond to therapy in ways different from classical PRP.


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