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  Table of Contents  
CASE REPORT
Year : 2015  |  Volume : 6  |  Issue : 4  |  Page : 277-279  

Intravascular papillary endothelial hyperplasia: An unusual histopathological entity


Department of Pathology, Army College of Medical Sciences and Base Hospital, New Delhi, India

Date of Web Publication8-Jul-2015

Correspondence Address:
Ajay Malik
Department of Pathology, Army College of Medical Sciences and Base Hospital, New Delhi
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2229-5178.160269

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   Abstract 

Intravascular papillary endothelial hyperplasia (Masson's tumor) is a benign lesion of the skin and subcutaneous tissue consisting of a reactive proliferation of endothelial cells with papillary formations related to a thrombus. It poses a diagnostic challenge as the clinical signs and symptoms are nonspecific and may mimic a soft tissue sarcoma. The diagnosis is based on histopathology. Here we report two cases of Masson's hemangioma occurring on the upper lip and on the left hand.

Keywords: Hemangioma, intravascular papillary endothelial hyperplasia, thrombus


How to cite this article:
Mahapatra QS, Sahai K, Malik A, Mani N S. Intravascular papillary endothelial hyperplasia: An unusual histopathological entity. Indian Dermatol Online J 2015;6:277-9

How to cite this URL:
Mahapatra QS, Sahai K, Malik A, Mani N S. Intravascular papillary endothelial hyperplasia: An unusual histopathological entity. Indian Dermatol Online J [serial online] 2015 [cited 2017 Dec 11];6:277-9. Available from: http://www.idoj.in/text.asp?2015/6/4/277/160269


   Introduction Top


In 1923, Pierre Masson first described an intravascular papillary proliferation formed within the lumen of inflamed hemorrhoidal plexus in a man and named it "Hemangioendotheliome vegetant intravasculaire." [1] From the time of its initial description it has been referred to by various eponyms, including Masson's tumor, Masson's hemangioma, Masson's intravascular hemangioendothelioma, intravascular papillary endothelial hyperplasia (IPEH) or reactive papillary endothelial hyperplasia. [2] Masson described it to be a form of neoplasm and explained the pathogenesis as proliferation of endothelial cells into the vessel lumen, followed by obstruction and secondary degeneration and necrosis. On the other hand, Henschen [3] depicted the lesion as a reactive process rather than a neoplasm. Kauffman and Stout [3] remarked that, although endothelial proliferation that can be easily mistaken for a characteristic of sarcoma is present, the endothelial layer of the lesion is composed of normal endothelial cells, the endothelial proliferation is of benign papillae pattern and the cells show no atypia. However, it is now believed to be a reactive vascular proliferation following traumatic vascular stasis, and the current terminology, IPEH, was proposed by Clearkin and Enzinger [2] in 1976. It is a rare benign condition mimicking angiosarcoma and hence it is being reported here.


   Case reports Top


Case 1

A 25-year-old female presented with a firm, painless, bluish, slow growing lesion in the upper lip, which was clinically diagnosed as papilloma. Excision of the mass was done and sent for histopathology examination. The H and E sections showed a dilated vessel with an organized thrombus and numerous papillae with a connective tissue core, lined by a single layer of endothelial cells with no atypia, necrosis and mitosis. The lesion was well-circumscribed and contained inside the vascular wall. Thus malignancy was excluded and a diagnosis of IPEH (Masson's hemangioma) of the lip [Figure 1] and [Figure 2] was made.
Figure 1: The lesion showing an organizing thrombus in a dilated vessel accompanied by a papillary formation (H and E, ×100)

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Figure 2: Intravascular papillary endothelial hyperplasia. A thrombus and papillae lined by single layer of benign endothelial cells (H and E, ×400)

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Case 2

A 31-year-old man was admitted to our hospital with the complaint of swelling on his left hand. Clinically it was a firm, smooth, round and slightly painful swelling. Biopsy was done and H and E sections revealed under a normal stratified squamous epithelium, a well-circumscribed lesion with multiple small papillary structures, [Figure 3] covered by a single layer of endothelium with no atypia. Some of the papillae were attached to the vascular wall and others were lying free in the lumen. Absence of mitotic figures, necrosis, nuclear pleomorphism, and infiltration into adjacent tissue, ruled out malignancy in this case. Abutting to these papillae were areas which showed cystically dilated thin walled vessels filled with blood [Figure 3]. Thus a diagnosis of IPEH superimposed on a cavernous hemangioma (secondary Masson's hemangioma) was given.
Figure 3: The lesion is well-circumscribed with multiple small papillary structures (arrows) and abutting to the papillae are dilated blood vessels (cavernous hemangioma). Overlying epithelium is also seen (H and E, ×100)

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   Discussion Top


Intravascular papillary endothelial hyperplasia is a reactive proliferative lesion of endothelial cells in blood vessels. It is an unusual lesion constituting about 2% of the benign and malignant vascular tumors of the skin and subcutaneous tissues. [4] IPEH may occur in any part of the body and there is a predilection for the deep dermis and subcutis of the head, neck, fingers and trunk. It usually presents as a small, firm, superficial mass with red to blue discoloration of the overlying skin. [5] However, the occurrence of IPEH in the oral cavity is extremely rare. A review in the accessible literature showed <80 cases of IPEH in the oral mucosa and lips. [3] Deep-seated IPEH of the extremities arising from preexisting, intramuscular, cavernous hemangiomas, are considered to be very rare. We report these two cases of Masson's hemangioma because of their rare location - the lip and the forearm. The latter site was associated with cavernous hemangioma, a rare variant of IPEH.

There is no gender or age predilection and it has been equally reported in males and females. However, Pins et al. reported a female: male ratio of 1.2:1.0 with an average age of presentation of 34 years. [6]

Two theories have been proposed to account for the pathogenesis of this lesion. The first theory originally proposed by Masson, states that endothelial proliferation is the primary phenomenon whereas the thrombus arises secondary to endothelial proliferation. [2] In contrast, Clearkin and Enzinger in 1976 suggested that this papillary structure appears after a preexisting thrombus organizes. Nowadays, it is considered to be a reactive vascular proliferation following traumatic vascular stasis. The pathogenesis of IPEH might be related to inflammation or mechanical stimulus such as irritation. It has been proposed that IPEH formation is triggered off with release of basic fibroblast growth factor (FGF) by the invading macrophages to the trauma site with proliferation of endothelial cells. Further release of more basic FGF by the proliferating endothelial cells occur, cascading into a positive feedback of endothelial cell proliferation. [7]

Three clinical types of this lesion have been described. [8] A primary or "pure" form arises within a normal blood vessel, most commonly a vein, and is often sited on the fingers, head and neck, and forearms. Our first case that originated in a blood vessel of the lip without any secondary lesion was of the above type. The secondary lesion or "mixed" form arises in the setting of a preexisting vascular malformation, such as a hemorrhoidal vein, cavernous hemangioma or pyogenic granuloma and may be sited intramuscularly. Our second case belonged to this category as it originated in a cavernous hemangioma. The rarest type, an extravascular hemangioma, usually arises from an organizing hematoma.

Microscopy is very important for its diagnosis. IPEH consists of an intravascular proliferation of numerous papillae with a core of connective tissue and an endothelial surface. It can be distinguished from other neoplastic lesions because it is frequently well-circumscribed or encapsulated, with characteristic papillary fronds, and the proliferative process is entirely limited by the vascular wall [2] as seen in both of our cases. A major differential of IPEH is angiosarcoma. The papillary structure and exuberant endothelisation of IPEH necessitates ruling out the much more frequent angiosarcoma. The following features are important in the differential diagnosis: (a) IPEH is often well-circumscribed or encapsulated; (b) the proliferative process is completely limited to the intravascular spaces; (c) though the endothelial cells are hyperchromatic, extreme nuclear atypia and frequent mitotic figures cannot be seen; (d) papillae are composed of fibrohyalinized tissue of two or more endothelial cell layers without any covering; (e) there is no true endothelial confirmation of IPEH; (f) tangential sectioning may reveal pseudochannels, but no irregular or anastomosing blood vessels in the stroma; and (g) necrosis is an unusual finding in IPEH. [9]

However angiosarcoma invades tissues outside the vascular channels and has more than one or two layers of endothelial cells covering the papillary formation. It also shows more malignant features on cytology, [10] such as mitotic figures, necrosis, nuclear pleomorphism, and infiltration into adjacent tissue.

Immunohistochemical confirmation may be required only if the endothelial origin of the lesion is in question. In such cases endothelial cell markers, such as von Willebrand factor, CD31, factor XIIIa, and CD43 may be used, which would highlight the endothelial lining around the papillary tufts. The treatment for IPEH is surgical excision with complete resection. [11]

The importance of IPEH or Masson's hemangioma lies in the fact that it histologically simulates angiosarcoma. Moreover, it tends to recur if incompletely resected. Correct diagnosis of this entity is essential to prevent aggressive treatment.

 
   References Top

1.
Yücesoy C, Coban G, Yilmazer D, Oztürk E, Hekimoglu B. Intravascular papillary endothelial hyperplasia (Masson's hemangioma) presenting as a lateral neck mass. JBR-BTR 2009;92:20-2.  Back to cited text no. 1
    
2.
Fasina O, Adeoye A, Akang E. Orbital intravascular papillary endothelial hyperplasia in a Nigerian child: A case report and review of the literature. J Med Case Rep 2012;6:300.  Back to cited text no. 2
    
3.
Narwal A, Sen R, Singh V, Gupta A. Masson's hemangioma: A rare intraoral presentation. Contemp Clin Dent 2013;4:397-401.  Back to cited text no. 3
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4.
Amérigo J, Berry CL. Intravascular papillary endothelial hyperplasia in the skin and subcutaneous tissue. Virchows Arch A Pathol Anat Histol 1980;387:81-90.  Back to cited text no. 4
    
5.
Park SJ, Kim HJ, Park SH, Yeo UC, Lee ES. A case of intravascular papillary endothelial hyperplasia on upper lip. Korean J Dermatol 2000;38:1693-5.  Back to cited text no. 5
    
6.
Pins MR, Rosenthal DI, Springfield DS, Rosenberg AE. Florid extravascular papillary endothelial hyperplasia (Masson's pseudoangiosarcoma) presenting as a soft-tissue sarcoma. Arch Pathol Lab Med 1993;117:259-63.  Back to cited text no. 6
    
7.
Levere SM, Barsky SH, Meals RA. Intravascular papillary endothelial hyperplasia: A neoplastic "actor" representing an exaggerated attempt at recanalization mediated by basic fibroblast growth factor. J Hand Surg Am 1994;19:559-64.  Back to cited text no. 7
    
8.
Hashimoto H, Daimaru Y, Enjoji M. Intravascular papillary endothelial hyperplasia. A clinicopathologic study of 91 cases. Am J Dermatopathol 1983;5:539-46.  Back to cited text no. 8
    
9.
Farah JM, Sawke N, Sawke GK. Cutaneous intravascular papillary endothelial hyperplasia of the forearm: A case report. Peoples J Sci Res 2013;6:38-40.  Back to cited text no. 9
    
10.
Shields JA, Shields CL, Eagle RC Jr, Diniz W. Intravascular papillary endothelial hyperplasia with presumed bilateral orbital varices. Arch Ophthalmol 1999;117:1247-9.  Back to cited text no. 10
    
11.
Kumar A, Surowiec S, Nigwekar P, Illig KA. Masson's intravascular hemangioma masquerading as effort thrombosis. J Vasc Surg 2004;40:812-4.  Back to cited text no. 11
    


    Figures

  [Figure 1], [Figure 2], [Figure 3]


This article has been cited by
1 Oral intravascular papillary endothelial hyperplasia: Case report and review of literature
Mayara Santos de Castro,Marina Lara de Carli,Fernanda Salgueiredo Giudice,Suzana Cantanhede Orsini Machado de Sousa,Alessandro Antônio Costa Pereira,João Adolfo Costa Hanemann,Felipe Fornias Sperandio
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 2016;
[Pubmed] | [DOI]



 

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