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SKINDIA QUIZ
Year : 2016  |  Volume : 7  |  Issue : 4  |  Page : 348-349  

Sk India Quiz 26: Hypopigmented papules in a human immunodeficiency virus-positive patient


Department of Dermatology, Venereology and Leprology, R.N.T. Medical College, Udaipur, Rajasthan, India

Date of Web Publication5-Jul-2016

Correspondence Address:
Lalit Kumar Gupta
Department of Dermatology, Venereology and Leprology, R.N.T. Medical College, Udaipur - 313 001, Rajasthan
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2229-5178.182402

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How to cite this article:
Gupta LK, Balai M, Khare AK, Mittal A. Sk India Quiz 26: Hypopigmented papules in a human immunodeficiency virus-positive patient. Indian Dermatol Online J 2016;7:348-9

How to cite this URL:
Gupta LK, Balai M, Khare AK, Mittal A. Sk India Quiz 26: Hypopigmented papules in a human immunodeficiency virus-positive patient. Indian Dermatol Online J [serial online] 2016 [cited 2019 Dec 6];7:348-9. Available from: http://www.idoj.in/text.asp?2016/7/4/348/182402

A 40-year-old human immunodeficiency virus. (HIV)-positive male presented with one year history of multiple, asymptomatic, hypopigmented lesions on upper limb and trunk. The patient was on zidovudine, lamivudine, and nevirapine for 9. months. His CD4 count was 92. cells/mm3. Physical examination showed scaly, discrete to confluent papules of 1-3. mm size and distributed symmetrically on shoulder, arms and trunk [Figure 1]a. Koebnerization was evident at some places. Some of the confluent lesions had figurate morphology [Figure 1]b. None of the family members had similar lesions. Potassium hydroxide examination of scraped hypopigmented skin lesions did not show fragmented hyphae. Histopathology showed broad plate like epidermal hyperplasia with focal hypergranulosis and several vacuolated cells (koilocytes) with abundant pale cytoplasm in the upper spinous layer [Figure 2]a,[Figure 2]b.


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   References Top

1.
Majewski S, Jabłońska S. Epidermodysplasia verruciformis as a model of human papillomavirus-induced genetic cancer of the skin. Arch Dermatol 1995;131:1312-8.  Back to cited text no. 1
    
2.
Kirnbauer R, Lenz P. Human papillomaviruses. In: Bolognia JL, Jorizzo JL, Schaffer JV, editors. Dermatology. 3rd ed. China: Elsevier Saunders; 2012. p. 1303-19.  Back to cited text no. 2
    
3.
Androphy EJ, Kirnbauer R. Human papilloma virus infections. In: Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Lefell DJ, Wolff K, editors. Fitzpatrick's Dermatology in General Medicine. 8th ed. New York: McGraw Hill; 2012. p. 2421-33.  Back to cited text no. 3
    
4.
Morrison C, Eliezri Y, Magro C, Nuovo GJ. The histologic spectrum of epidermodysplasia verruciformis in transplant and AIDS patients. J Cutan Pathol 2002;29:480-9.  Back to cited text no. 4
    
5.
Berthelot C, Dickerson MC, Rady P, He Q, Niroomand F, Tyring SK, et al. Treatment of a patient with epidermodysplasia verruciformis carrying a novel EVER 2 mutation with imiquimod. J Am Acad Dermatol 2007;56:882-6.  Back to cited text no. 5
    
6.
Janssen K, Lucker GP, Houwing RH, van Rijssel R. Epidermodysplasia verruciformis: Unsuccessful therapeutic approach with imiquimod. Int J Dermatol 2007;46 Suppl 3:45-7.  Back to cited text no. 6
    
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