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BRIEF REPORT
Year : 2017  |  Volume : 8  |  Issue : 6  |  Page : 468-470

Mean platelet volume: A reliable marker of inflammation in recurrent apthous stomatitis and behçet disease?


1 Department of Dermatology, Faculty of Medicine, Hitit University; Beekeeping and Bee Products Application and Research Center, Hitit University, Çorum, Turkey
2 Clinic of Internal Medicine, Çankiri State Hospital, Çankiri, Turkey
3 Department of Dermatology, Faculty of Medicine, Hitit University, Çorum, Turkey

Correspondence Address:
Engin Senel
Department of Dermatology, Faculty of Medicine, Hitit University, Çorum
Turkey
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/idoj.IDOJ_405_16

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Background: Mean platelet volume (MPV) is an indicator of platelet activation and aggregation. MPV has been found to be related with the inflammation of certain disorders in recent studies. Aims: We sought to investigate whether MPV could be an indicator of inflammation in patients with Behçet disease (BD) and recurrent apthous stomatitis (RAS). Materials and Methods: Our study was designed as a retrospective case-control study and data was retrieved from our institutional database. We randomly generated a total of three study groups from our clinical archive. All controls were sex and age-matched and randomly selected by computer. Eighty-five patients with BD, 82 patients with RAS, and 721 healthy controls were included for the study design. We compared mean MPV values in the patient groups and controls. Results: We found no difference in the mean MPV value between BD group and BD-control group. The mean MPV value was significantly higher in patients with RAS than that in the RAS-control group (9.11 ± 1.01 fL vs. 8.76 ± 1.15 fL, P = 0.045). There was no difference in mean MPV level between BD and RAS group. Conclusion: The association between MPV and inflammatory skin diseases such as BD and RAS should be investigated prospectively in case-control studies. Limitations: Retrospective study design.


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