|Year : 2018 | Volume
| Issue : 3 | Page : 214-215
SkinIndia Quiz 45: Asymptomatic nodular lesion over the neck in an old woman
Suman Patra, Sanjay Singh, Neetu Bhari
Department of Dermatology and Venereology, All Institute of Medical Sciences, New Delhi, India
|Date of Web Publication||2-May-2018|
Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Patra S, Singh S, Bhari N. SkinIndia Quiz 45: Asymptomatic nodular lesion over the neck in an old woman. Indian Dermatol Online J 2018;9:214-5
|How to cite this URL:|
Patra S, Singh S, Bhari N. SkinIndia Quiz 45: Asymptomatic nodular lesion over the neck in an old woman. Indian Dermatol Online J [serial online] 2018 [cited 2020 Jan 29];9:214-5. Available from: http://www.idoj.in/text.asp?2018/9/3/214/227684
| Clinical Findings|| |
A 56-year-old woman presented with an 8-month history of single, asymptomatic nodule over the neck, which was progressively increasing in size. The patient was systemically well. On examination, there was a single firm nodule of size 2.5 × 3.5 cm over the right lateral aspect of the neck. The nodule was dark brown in color and was fixed to the overlying skin. The lesion had a lobulated appearance with a zone of erythema at the periphery [Figure 1]. An excision biopsy was performed to reach a diagnosis.
|Figure 1: Single firm nodule over the neck with overlying thick skin giving a lobulated appearance and a zone of erythema at the periphery|
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| Histopathologic Findings|| |
Hematoxylin and eosin stain of the tissue showed diffuse infiltration of the dermis with uniform looking cells. The cells had centrally located nuclei and granular eosinophilic cytoplasm. There was no significant nuclear atypia or mitotic activity [Figure 2]a and [Figure 2]b. The excised margin was free from tumor. Immunohistochemistry with S100 revealed a strong positive staining [Figure 2]c.
|Figure 2: Hematoxylin and eosin stain: (a and b) (×40) showed diffuse infiltration of the dermis with uniform looking cells. These cells had centrally located nuclei and granular eosinophilic cytoplasm. There was no significant nuclear atypia or mitotic activity. (c) (×40): Immunohistochemistry with S100 revealed a strong positive staining|
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| Question|| |
What is your diagnosis?
| References|| |
Boulos R, Marsot-Dupuch K, De Saint-Maur P, Meyer B, Tran Ba Huy P. Granular cell tumor of the palate: A case report. AJNR Am J Neuroradiol 2002;23:850-4.
Deavers M, Guinee D, Koss MN, Travis WD. Granular cell tumors of the lung. Clinicopathologic study of 20 cases. Am J Surg Pathol 1995;19:627-35.
Battistella M, Cribier B, Feugeas JP, Roux J, Le Pelletier F, Pinquier L, et al
. Cutaneous Histopathology Section of the French Society of Dermatology. Vascular invasion and other invasive features in granular cell tumours of the skin: A multicentre study of 119 cases. J Clin Pathol 2014;67:19-25.
Vered M, Carpenter WM, Buchner A. Granular cell tumor of the oral cavity: Updated immunohistochemical profile. J Oral Pathol Med 2009;38:150-9.
Daulatabad D, Grover C, Tanveer N, Bansal D. Granular cell tumor in a child: An uncommon cutaneous presentation. Indian Dermatol Online J 2016;7:390-2.
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[Figure 1], [Figure 2]