|Year : 2018 | Volume
| Issue : 4 | Page : 282-283
SkinIndia Quiz 46: Asymptomatic unilateral inguinal swelling with peripheral eosinophilia
Sidharth Tandon1, Jasmeet Singh2, Surabhi Sinha1, Preeti Sharma3
1 Department of Dermatology, Venereology and Leprosy, Dr. Ram Manohar Lohia Hospital and Post Graduate Institute of Medical Education and Research, New Delhi, India
2 Department of Dermatology, Venereology and Leprosy, Dr. Baba Saheb Ambedkar Medical College and Hospital, New Delhi, India
3 Department of Pathology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India
|Date of Web Publication||2-Jul-2018|
Department of Dermatology, Venereology and Leprosy, Dr. Ram Manohar Lohia Hospital and Post Graduate Institute of Medical Education and Research, Baba Kharak Singh Marg, New Delhi - 110001
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Tandon S, Singh J, Sinha S, Sharma P. SkinIndia Quiz 46: Asymptomatic unilateral inguinal swelling with peripheral eosinophilia. Indian Dermatol Online J 2018;9:282-3
|How to cite this URL:|
Tandon S, Singh J, Sinha S, Sharma P. SkinIndia Quiz 46: Asymptomatic unilateral inguinal swelling with peripheral eosinophilia. Indian Dermatol Online J [serial online] 2018 [cited 2019 Dec 6];9:282-3. Available from: http://www.idoj.in/text.asp?2018/9/4/282/231793
Clinical History and Examination
A 50-year-old male presented with right-sided inguinal swelling [Figure 1] for the past 1 year. Previously, the patient was clinically diagnosed as a case of tubercular lymphadenopathy and had received 6 months of antitubercular therapy without any noticeable improvement. Cutaneous examination revealed a single, mobile, firm, nontender, matted, irregular mass of size 6 Χ 6 cm in the right inguinal regional with normal overlying skin. Blood investigations showed peripheral eosinophilia (52%) with an absolute eosinophil count of 4500/mm3 and normal erythrocyte sedimentation rate. A regional fine needle aspiration cytology showed features of reactive lymphoid hyperplasia. The results of renal function tests, liver function tests, and routine urine tests were within normal limits, and chest radiography was unremarkable. Mantoux test was 5 × 5 mm.
A lesional biopsy revealed preserved architecture of lymphoid follicles with prominent germinal centers. Interfollicular areas showed prominence of eosinophils
and plasma cells along with the presence of an occasional multinucleate giant cell [Figure 2]. Eosinophils were also seen infiltrating into lymphoid follicles and the capsule, with proliferation of capillaries and venules [Figure 3]. Stains and cultures were negative for bacteria, fungi, and mycobacteria.
|Figure 2: Photomicrograph shows presence of sheets of eosinophils along with admixed plasma cells. Occasional multinucleated giant cell is also noted (H and E ×200).|
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|Figure 3: Higher magnification shows a mixed population of eosinophils and plasma cells intermixed with mature lymphoid tissue (H and E ×400)|
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What is Your Diagnosis?
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[Figure 1], [Figure 2], [Figure 3]