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Year : 2019  |  Volume : 10  |  Issue : 5  |  Page : 601-605

Selection of control, randomization, blinding, and allocation concealment

1 Department of Pharmacology, Rampurhat Government Medical College, Rampurhat, Birbhum, West Bengal, India
2 Department of Dermatology, Katihar Medical College and Hospital, Bihar, India
3 Department of Dermatology, Grant Medical College and Bombay Hospital Institute of Medical Sciences, Mumbai, Maharashtra, India
4 Department of Dermatology, Bankura Sammilani Medical College, Kenduadihi, Bankura, West Bengal, India

Correspondence Address:
Nilay Kanti Das
Department of Dermatology, Bankura Sammilani Medical College, Kenduadihi, Bankura - 722 102, West Bengal
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/idoj.IDOJ_149_19

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Clinical trials looking at which treatment is better must have certain checks in place. Appropriate “control” selection while comparing the investigating agent to the “control group is essential to rule out selection bias. Randomization is another step to minimize variability or “confounders.” By randomization, research participants have an equal chance of being selected into any treatment group of the study, generating comparable intervention groups, thereby distributing the confounders. A trial can be “open labeled” or “blinded.” By the process of blinding, we make the participant and/or assessing physician unaware of the treatment he/she is going to receive. Thus, the element of bias which can creep in owing to personal preference or subjective component to the assessment of outcome can be eliminated. Concealment of allocation is done as the participant enters the trial. Concealment secures randomization and prevents “selection bias”.

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