|Year : 2019 | Volume
| Issue : 6 | Page : 686-691
Ichthyosis follicularis, alopecia, and photophobia (IFAP) syndrome: A case report and review of cases reported from India
Anupama Bains1, Deepak Vedant2, Anurag Verma3, Abhishek Bhardwaj1, Aasma Nalwa2
1 Department of Dermatology, Venereology and Leprology, Mayo Institute of Medical Sciences, Barabanki, Uttar Pradesh, India
2 Department of Pathology, AIIMS, Jodhpur, Rajasthan, India
3 Department of Dermatology, Mayo Institute of Medical Sciences, Barabanki, Uttar Pradesh, India
|Date of Web Publication||1-Nov-2019|
Room No. 307, Resident Hostel, AIIMS, Basni Phase- 2, Jodhpur - 342 005, Rajasthan
Source of Support: None, Conflict of Interest: None
| Abstract|| |
Ichthyosis follicularis, alopecia, and photophobia (IFAP) syndrome is characterized by the triad of follicular keratotic papules, total to subtotal alopecia, and photophobia. We hereby report a case of IFAP syndrome in a 1-year-old boy who presented with all these classical features along with hyperkeratotic plaques over knees, plantar keratoderma, and umbilical hernia. Also, literature review of cases reported from India is being presented.
Keywords: Alopecia, ichthyoses follicularis, photophobia
|How to cite this article:|
Bains A, Vedant D, Verma A, Bhardwaj A, Nalwa A. Ichthyosis follicularis, alopecia, and photophobia (IFAP) syndrome: A case report and review of cases reported from India. Indian Dermatol Online J 2019;10:686-91
|How to cite this URL:|
Bains A, Vedant D, Verma A, Bhardwaj A, Nalwa A. Ichthyosis follicularis, alopecia, and photophobia (IFAP) syndrome: A case report and review of cases reported from India. Indian Dermatol Online J [serial online] 2019 [cited 2020 Jan 27];10:686-91. Available from: http://www.idoj.in/text.asp?2019/10/6/686/270202
| Introduction|| |
Ichthyosis follicularis, alopecia, and photophobia (IFAP) syndrome is an extremely rare X-linked oculocutaneous genetic disorder with only 37 cases reported in literature till 2011. It is characterized by the triad of follicular keratotic papules, total to subtotal alopecia, and photophobia. Missense mutation in gene MBTPS2 at Xp22.11.3 has been identified in many patients affected with this syndrome. This causes functional deficiency of membrane-bound transcription factor protease, site 2 (MBTPS2), an intramembrane zinc metalloprotease which further disturbs either sterol or endoplasmic reticulum homeostasis and may impair the differentiation of epidermal structures. We hereby report a case of IFAP syndrome.
| Case Report|| |
A 1-year-old boy born to nonconsanguineous parents presented with alopecia over scalp and dry rough skin since birth. There was also history of difficulty in opening the eyes and watering from eyes in exposure to light since birth. His antenatal and perinatal history was unremarkable. There was no history of mental retardation and developmental delay. There was no neurological and hearing deficit. There was no history of similar complaints in the family. On cutaneous examination, there were multiple follicular keratotic papules over whole body predominantly involving scalp, trunk, and extensors of extremities [Figure 1]. Over both knees there were two well-defined mildly erythematous to skin colored lichenified plaques of size approximately 3×2 cm one on each side [Figure 2]. Both soles showed thickened and fissured skin [Figure 3]. Palms were normal. The hair over scalp were sparse, short and thinned out, light brown with complete loss of eyebrows and eyelashes and body hair [Figure 4]. Alopecia was nonscarring in nature. Microscopic examination of hair did not show any abnormality. Ophthalmological examination revealed dry eyes. There was also presence of umbilical hernia [Figure 1]. Oral mucosa, nails, teeth, and sweating were normal. Ophthalmological examination of mother was normal. Skin biopsy from keratotic papule showed occasional plugging of the follicle by a thick deposition of the keratinous material and absence of hair shaft [Figure 5]. In view of above clinical and histopathological features diagnosis of IFAP syndrome was made. Genetic analysis was not done because of financial constraints. Patient was prescribed topical urea-based emollients along with lubricating eye drops. This was followed by mild to moderate improvement in cutaneous lesions and ocular symptoms. Parents were counselled regarding the genetic basis of disease.
|Figure 1: Multiple follicular keratotic papules over abdomen with umbilical hernia|
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|Figure 5: Skin biopsy from keratotic papule showed occasional plugging of the follicle by a thick deposition of the keratinous material and absence of hair shaft. (H and E original magnification 4×)|
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| Discussion|| |
First case of IFAP syndrome was reported by Mcleod in 1909. Common manifestations of this syndrome are follicular keratotic papules, alopecia, and photophobia. Follicular papules usually involve scalp, extensor aspect of extremities, and give sandpaper-like texture to skin. Alopecia is congenital, nonscarring, involves scalp, eyebrows, eyelashes, and sometimes is universal. Photophobia is caused by corneal defects like erosions, ulcers, scars, and neovascularization. Other ocular changes can be scarring atopic keratoconjunctivitis, nystagmus, and myopia. Retinal vascular tortuosity may be a clinical sign in carrier females. Ocular examination in our patient revealed dry eyes. Similar changes were reported by Lal et al.
The disease may manifest from mild to severe form. Mild form is limited to skin, while BRESHECK is the severe form which manifests as multiple extracutaneous features like brain anomalies, retardation, ectodermal dysplasia, skeletal deformities, Hirschsprung disease, ear/eye anomalies, cleft palate/cryptorchidism, and kidney dysplasia/hypoplasia. Other additional features which may be present are growth retardation, psychomotor development delay, seizures, recurrent pneumonia, inguinal, and umbilical hernia. In our patient, there was presence of associated umbilical hernia.
Patient can have psoriasiform plaques, cheilitis, hypohidrosis, nail dystrophy, atopic dermatitis, and keratoderma. Hyperkeratoses over elbows and knees have been described earlier in few case reports. Associated palmoplantar keratoderma have been described by Rai and Shenoi and Alshami et al., In our patient, hyperkeratotic plaques were present over both knees along with plantar keratoderma. Carrier females may have hyperkeratotic lesion along Blashko's lines and asymmetric distribution of body hair. Histopathology from cutaneous lesions show follicular plugging, acanthotic infundibular epidermis, and hypoplasia of sebaceous glands.
To the best of our knowledge only ten cases have been reported from India. Review of these cases showed that the disease manifested predominantly in males. Only one female was reported with this disease. This suggests X-linked recessive inheritance of disease. Onset of cutaneous lesions was since birth in almost all cases. Follicular papules, alopecia, and photophobia were nearly present in all patients. Follicular papules were predominantly distributed over scalp, trunk, and extremities. Alopecia involved scalp, eyebrows, and eyelashes except in one case where scalp hair was normal. Photophobia was absent in one patient. Ocular examination showed abnormal findings in fivepatients and was in the form of corneal xerosis, vascularization, keratitis, opacity, and Meibomitis More Details. Hyperkeratotic plaques over elbows and knees were present in two patients, palmoplantar keratoderma in threepatients, nail dystrophy in threepatients, angular cheilitis in twopatients, retarded physical growth in threepatients, delayed milestones in twopatients, seizures in twopatients, family history in twopatients, inguinal hernia in onepatient, and recurrent respiratory infection in twopatients. Skin biopsy showed follicular plugging in most of the patients. Mutation analysis was not done in any patient [Table 1].,,,,,,,,,
IFAP syndrome needs to be differentiated from other diseases. Mutations in MBTPS2 have also been found keratosis follicularis spinulosa decalvans (KFSD) and X-linked Olmsted-like syndrome. There is overlap of clinical features in IFAP and KFSD. Both are distinguished by presence of scarring and patchy alopecia in KFSD, also the alopecia is not congenital in KFSD. KFSD usually manifests in early childhood. Symptoms tend to decrease with age and the long-term prognosis for vision is usually good. It has to be differentiated from keratitis ichthyosisdeafness syndrome where there is erythrokeratoderma and congenital hearing loss. Other differentials include papular atrichia and hereditary mucoepithelial dysplasia (HMD). Congenital atrichia with papular lesions presents with hair loss with papules which on histopathology are small keratinous cysts. HMD consists of triad of nonscarring alopecia, well-demarcated fiery red mucosa, and psoriasiform perineal lesions.
There is no permanent cure and genetic counselling of patients is important. Though initially thought to be X-linked recessive disorder but there are some reports in literature where females were also affected. This may reflect genetic heterogeneity of this disorder or autosomal dominant mode of inheritance., Heterozygous female carriers can present with patches of alopecia over scalp, linear hyperkeratotic plaques, follicular atrophoderma, and hypohidrosis. However, findings of atrophoderma and hypohidrosis are absent in male patients.
Temporary reduction in cutaneous lesions can be seen with topical keratolytics like urea, topical tretinoin, and topical steroids. Systemic therapy in the form of oral vitamin A, 250 000 units/day, administered for 6 months was used in in one case which led to improvement in photophobia and cutaneous lesions. Moderate response to oral retinoids has been seen in some patients. In one case oral acitretin 1 mg/kg/day was given for 6 months which resulted in flattening of cutaneous lesions, but there was no response in alopecia and ocular symptoms. Similarly, oral isotretinoin 0.5 mg/kg/day for 4 months resulted in marked improvement in cutaneous lesions in one case. However, there was reoccurrence after discontinuation of treatment. Life expectancy of patients can vary from normal survival to death in the neonatal period from cardiopulmonary complications.
| Conclusion|| |
The index patient presented with characteristic triad of follicular keratotic papules, atrichia, and photophobia syndrome along with hyperkeratotic plaques over both knees, plantar keratoderma, and umbilical hernia. This case is being reported to increase the clinician's awareness regarding diagnosis of this rare disease.
Declaration of patient consent
The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
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