Indian Dermatology Online Journal

DRUG PROFILE
Year
: 2011  |  Volume : 2  |  Issue : 2  |  Page : 111--119

Fumaric acid esters in dermatology


Uwe Wollina 
 Department of Dermatology and Allergology, Hospital Dresden Friedrichstadt, Academic Teaching Hospital of the Technical University of Dresden, Dresden, Germany

Correspondence Address:
Uwe Wollina
Head of the Department of Dermatology and Allergology, Hospital Dresden Friedrichstadt, Academic Teaching Hospital of the Technical University of Dresden, Friedrichstrasse 41, 01067 Dresden
Germany

Fumaric acid esters (FAE) are substances of interest in dermatology. FAE exert various activities on cutaneous cells and cytokine networks. So far only a mixture of dimethylfumarate (DMF) and three salts of monoethylfumarate (MEF) have gained approval for the oral treatment of moderate-to-severe plaque-type psoriasis in Germany. DMF seems to be the major active component. There is evidence that FAE are not only effective and safe in psoriasis but granulomatous non-infectious diseases like granuloma annulare, necrobiosis lipoidica and sarcoidosis. In vitro and animal studies suggest some activity in malignant melanoma as well.


How to cite this article:
Wollina U. Fumaric acid esters in dermatology.Indian Dermatol Online J 2011;2:111-119


How to cite this URL:
Wollina U. Fumaric acid esters in dermatology. Indian Dermatol Online J [serial online] 2011 [cited 2020 Jul 14 ];2:111-119
Available from: http://www.idoj.in/article.asp?issn=2229-5178;year=2011;volume=2;issue=2;spage=111;epage=119;aulast=Wollina;type=0