Indian Dermatology Online Journal

LETTER TO THE EDITOR
Year
: 2016  |  Volume : 7  |  Issue : 6  |  Page : 541--543

Coexistence of psoriasis and primary high-grade subcutaneous leiomyosarcoma


Nikita Patel1, Vishalakshi Viswanath1, Bharat Rekhi2,  
1 Department of Dermatology, Rajiv Gandhi Medical College and Chattrapati Shivaji Maharaj Hospital, Thane, Maharashtra, India
2 Department of Pathology, Tata Memorial Hospital, Mumbai, Maharashtra, India

Correspondence Address:
Nikita Patel
Department of Dermatology, Rajiv Gandhi Medical College and Chattrapati Shivaji Maharaj Hospital, Thane - 400 605, Maharashtra
India




How to cite this article:
Patel N, Viswanath V, Rekhi B. Coexistence of psoriasis and primary high-grade subcutaneous leiomyosarcoma.Indian Dermatol Online J 2016;7:541-543


How to cite this URL:
Patel N, Viswanath V, Rekhi B. Coexistence of psoriasis and primary high-grade subcutaneous leiomyosarcoma. Indian Dermatol Online J [serial online] 2016 [cited 2019 Nov 20 ];7:541-543
Available from: http://www.idoj.in/text.asp?2016/7/6/541/193918


Full Text

Sir,

Psoriasis is a chronic relapsing inflammatory skin disease. Studies associate an increased risk of certain cutaneous and lymphoproliferative malignancies with psoriasis.[1],[2],[3]

Primary cutaneous leiomyosarcomas (PCL) are rare soft tissue sarcomas displaying smooth muscle differentiation. They often present as a painful nodule over the extensor surfaces. Their etiology is relatively unknown.

The coexistence of these two distinct entities in a patient has been described.

A 58-year-old man presented with a slow growing, painless, reddish mass over his right flank since 6 months. He was a known case of plaque psoriasis since 25 years, treated only with topical steroids and emollients. There was no history of discharge, pain or previous trauma at local site. There were no systemic complaints. Cutaneous examination revealed a single, nontender, firm, exophytic tumor measuring 3.6 cm × 3.5 cm × 5 cm [Figure 1]a, over right lower back, with overlying skin showing ulceration [Figure 1]b. The tumor bled on manipulation. The skin underlying the tumor mass and surrounding the growth showed well-defined erythematous plaques with silvery scales. There was no significant lymphadenopathy. Dermatofibrosarcoma protuberans and cutaneous lymphoma were considered as differentials.{Figure 1}

Routine hematological and biochemical investigations were normal.

Histopathology of excision biopsy revealed a multinodular tumor involving dermis and subcutaneous tissue, composed of fascicles of atypical spindle cells, focally in a vascular pattern. The cells exhibited hyperchromatic and pleomorphic nuclei, mitotic figures, ranging from 5 to 6/10 high power fields, including atypical forms with focal tumor necrosis [Figure 2]a,[Figure 2]b,[Figure 2]c. Immunohistochemical stain for smooth muscle actin (SMA) and H-caldesmon was strongly positive [Figure 2]d and [Figure 2]e. It was negative for desmin, S100, MyoD1, and CD34. Final diagnosis of high-grade subcutaneous leiomyosarcoma was made. Computed tomogram (CT) scan of chest and ultrasonography of the abdomen were normal. The patient was treated with adjuvant radiotherapy for 6 months. There has been no evidence of tumor recurrence 1 year after therapy.{Figure 2}

Modest associations of psoriasis with lympho-hematopoeitic malignancy, nonmelanoma skin cancer, and melanoma have been reported.[1],[2] The risk is highest for those with severe psoriasis and also for patients treated with PUVA, methotrexate, cyclosporine, topical tar, and biologicals.

Sarcomas are uncommonly reported in psoriasis. Rare cases of Kaposi's sarcoma in psoriatics on immunosuppressants and ACE-inhibitors have been documented.[3]

A single case of retroperitoneal leiomyosarcoma with metastasis and cicatricial pemphigoid in a psoriatic patient has been reported.[4]

PCL account for 5%–10% of all soft tissue sarcomas.[5] Ionizing irradiation, sunlight, and trauma have been associated with PCL. Cases arising in angioleiomyoma and scars have been reported.[5] PCL are classified as dermal and subcutaneous, depending on their site of origin, histopathologic features, and biological behavior [Table 1].[5],[6] In the present case, the tumor mass replaced the entire dermis and subcutaneous tissue. It exhibited a focal vascular pattern, favoring a vascular smooth muscle origin, suggestive of the subcutaneous variant.{Table 1}

To the best of our knowledge, this is the first published case of PCL coexistent with psoriasis. It is difficult to speculate a plausible association between these two distinct conditions. However, any atypical changes in psoriatic plaques should validate a prompt evaluation to rule out malignant transformation.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

References

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2Bhattacharya T, Nardone B, Rademaker A, Martini M, Amin A, Al-Mudaimeagh HM, et al. Co-existence of psoriasis and melanoma in a large urban academic centre population: A cross-sectional retrospective study. J Eur Acad Dermatol Venereol 2016;30:83-5.
3Dervis E, Demirkesen C. Kaposi's sarcoma in a patient with psoriasis vulgaris. Acta Dermatovenerol Alp Pannonica Adriat 2010;19:31-4.
4David M, Oren N, Feuerman EJ. Occurrence of cicatricial pemphigoid and leiomyosarcoma in a psoriatic patient. Dermatologica 1985;170:256-9.
5Bali A, Kangle R, Roy M, Hungund B. Primary cutaneous leiomyosarcoma: A rare malignant neoplasm. Indian Dermatol Online J 2013;4:188-90.
6Weedon D, editor. Tumors of muscle, cartilage and bone. In: Weedon's Skin Pathology. 3rd ed. China: Churchill Livingstone; 2010. p. 861-2.