Indian Dermatology Online Journal

REVIEW ARTICLE
Year
: 2019  |  Volume : 10  |  Issue : 1  |  Page : 1--12

Apremilast in psoriasis and beyond: Big hopes on a small molecule


TP Afra1, T Muhammed Razmi1, Sunil Dogra2 
1 Department of Dermatology, IQRAA International Hospital and Research Centre, Calicut, Kerala, India
2 Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

Correspondence Address:
Sunil Dogra
Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh - 160 012
India

Apremilast, an orally administered small molecule inhibitor of phosphodiesterase 4 (PDE4), has been licensed by the US Food and Drug Administration for the management of active psoriatic arthritis (March 21, 2014) and moderate to severe plaque psoriasis (September 23, 2014). It has got approval from Drug Controller General of India for marketing in India in 2017. The drug has drawn much attention from the practising dermatologists for its commendable safety profile and prescription convenience. Introduced initially as an orally administered small molecule in psoriasis patients, the drug has now been used in various other indications as evident by the recent surge in literature for its off-label uses. Being a relatively new drug in the treatment armamentarium of psoriasis and other inflammatory dermatoses; in this review, we will discuss various practical aspects of prescribing oral apremilast, based on the current and emerging literature.


How to cite this article:
Afra T P, Razmi T M, Dogra S. Apremilast in psoriasis and beyond: Big hopes on a small molecule.Indian Dermatol Online J 2019;10:1-12


How to cite this URL:
Afra T P, Razmi T M, Dogra S. Apremilast in psoriasis and beyond: Big hopes on a small molecule. Indian Dermatol Online J [serial online] 2019 [cited 2019 Feb 17 ];10:1-12
Available from: http://www.idoj.in/article.asp?issn=2229-5178;year=2019;volume=10;issue=1;spage=1;epage=12;aulast=Afra;type=0