Indian Dermatology Online Journal

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 10  |  Issue : 6  |  Page : 627--631

Comparison of efficacy of two different concentrations of intralesional amphotericin B in the treatment of cutaneous leishmaniasis; A randomized controlled trial


Pooja Goswami, BC Ghiya, Vineet Kumar, S Rekha, RD Mehta 
 Department of Dermatology, Venereology and Leprosy, Sardar Patel Medical College, Bikaner, Rajasthan, India

Correspondence Address:
B C Ghiya
10, Medical College Road, Sadul Ganj, Bikaner, Rajasthan
India

Introduction: Cutaneous leishmaniasis is a vector borne disease caused by Leishmania major and Leishmania tropica. Bikaner is an endemic pocket for cutaneous leishmaniasis caused by Leishmania tropica. Materials and Methods: A prospective study was done to evaluate the efficacy of different concentrations of intralesional amphotericin B as a treatment modality for cutaneous leishmaniasis in Bikaner, Rajasthan, India from January 2016 to June 2017. Fifty patients were randomized into two groups, A and B. Twenty-five patients from group A, received intralesionl amphotericin B (2.5 mg/ml) 0.5 ml/cm2, weekly for 8 weeks. Another group of 25 patients were treated by intralesional amphotericin B (5.0 mg/ml) weekly for same period. The cases were followed-up for response, side effects, and recurrence of disease. Results: The results at the end of 8 weeks, showed complete response in 18 (72%) patients, partial response in 5 (20%) and 2 (8%) patients were non responders in group A. In group B, complete response was observed in 14 (56%), partial response in 7 (28%) patients and 4 (16%) patients did not show response. The difference was statistically insignificant (P > 0.05). No side effects were observed in both groups. Conclusion: The difference between the efficacy of 5 mg/ml and 2.5 mg/ml concentrations of Amphotericin B injections was found to be statistically insignificant. So, weekly injections of amphotericin B looks promising, however, larger sample size is required to assess the efficacy of both concentrations in the treatment of cutaneous leishmaniasis.


How to cite this article:
Goswami P, Ghiya B C, Kumar V, Rekha S, Mehta R D. Comparison of efficacy of two different concentrations of intralesional amphotericin B in the treatment of cutaneous leishmaniasis; A randomized controlled trial.Indian Dermatol Online J 2019;10:627-631


How to cite this URL:
Goswami P, Ghiya B C, Kumar V, Rekha S, Mehta R D. Comparison of efficacy of two different concentrations of intralesional amphotericin B in the treatment of cutaneous leishmaniasis; A randomized controlled trial. Indian Dermatol Online J [serial online] 2019 [cited 2019 Nov 21 ];10:627-631
Available from: http://www.idoj.in/article.asp?issn=2229-5178;year=2019;volume=10;issue=6;spage=627;epage=631;aulast=Goswami;type=0