Indian Dermatology Online Journal

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 10  |  Issue : 6  |  Page : 632--638

Clinicoepidemiologic features of chronic spontaneous urticaria in patients with elevated plasma D-dimer levels versus those without it: A case–control cross-sectional study of 100 indian patients


Shailja Chauhan1, Vikram K Mahajan1, Karaninder S Mehta1, Rajinder S Yadav2, Pushpinder S Chauhan1, Satya Bhushan2, Vikas Sharma1, Anuj Sharma1, Dhaarna Wadhwa1, Aditi Sharma1 
1 Department of Dermatology, Venereology and Leprosy, Dr. R. P. Govt. Medical College, Kangra (Tanda), Himachal Pradesh, India
2 Department of Biochemistry, Venereology and Leprosy, Dr. R. P. Govt. Medical College, Kangra (Tanda), Himachal Pradesh, India

Correspondence Address:
Vikram K Mahajan
Department of Dermatology, Venereology and Leprosy, Dr. R. P. Govt. Medical College, Kangra (Tanda) - 176 001, Himachal Pradesh
India

Background: Activated coagulation cascade is implicated in urticaria pathogenesis marked by high plasma D-dimer, a marker of fibrinolysis, levels correlating with high urticaria activity score (UAS) and poor therapeutic outcome. Methods: Quantitative plasma D-dimer levels and coagulation parameters in 100 (male:female ratio 1:3) Indian patients with chronic spontaneous urticaria and age- and gender-matched healthy controls were compared. The clinicoepidemiologic features of chronic urticaria were then compared among patients with normal (≤0.2 mg/L) and elevated (≥0.3 mg/L) plasma D-dimer levels. Results: Plasma D-dimer in 23% patients and 4% controls and prothrombin time and activated partial thromboplastin time in 63% and 5% patients, respectively, were significantly higher compared with 58% and 1% of controls, respectively. About 18 of 72 (25%) patients with high UAS of ≥16–42 were compared with 5 of 28 (17.8%) patients with UAS7 of ≤15. Patients with elevated plasma D-dimer levels had significantly more systemic symptoms (86.9% vs. 81.8%) compared with patients with normal plasma D-dimer levels. Conclusion: A subset of patients with chronic urticaria have elevated plasma D-dimer levels and exhibit higher UAS7 and systemic symptoms that may influence long-term prognosis and therapeutic choices. Small number of patients, a cross-sectional nature of study, lack of treatment outcome measures, information on self-medication, and unavailability of specific parameters for coagulation pathway activation remain few limitations of this study.


How to cite this article:
Chauhan S, Mahajan VK, Mehta KS, Yadav RS, Chauhan PS, Bhushan S, Sharma V, Sharma A, Wadhwa D, Sharma A. Clinicoepidemiologic features of chronic spontaneous urticaria in patients with elevated plasma D-dimer levels versus those without it: A case–control cross-sectional study of 100 indian patients.Indian Dermatol Online J 2019;10:632-638


How to cite this URL:
Chauhan S, Mahajan VK, Mehta KS, Yadav RS, Chauhan PS, Bhushan S, Sharma V, Sharma A, Wadhwa D, Sharma A. Clinicoepidemiologic features of chronic spontaneous urticaria in patients with elevated plasma D-dimer levels versus those without it: A case–control cross-sectional study of 100 indian patients. Indian Dermatol Online J [serial online] 2019 [cited 2019 Nov 13 ];10:632-638
Available from: http://www.idoj.in/article.asp?issn=2229-5178;year=2019;volume=10;issue=6;spage=632;epage=638;aulast=Chauhan;type=0