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   2013| January-March  | Volume 4 | Issue 1  
    Online since January 3, 2013

 
 
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MUSINGS, OPINIONS, TIPS AND EXPERIENCES
Treatment of nodular scabies with topical tacrolimus
Asit Mittal, Anubhav Garg, Nidheesh Agarwal, Lalit Gupta, Ashok K Khare
January-March 2013, 4(1):52-53
DOI:10.4103/2229-5178.105486  PMID:23437425
  25,505 1,098 3
REVIEW ARTICLES
Acne inversa (Hidradenitis suppurativa): A review with a focus on pathogenesis and treatment
Uwe Wollina, André Koch, Birgit Heinig, Thomas Kittner, Andreas Nowak
January-March 2013, 4(1):2-11
DOI:10.4103/2229-5178.105454  PMID:23439959
Acne inversa (AI) is a disabilitating chronic inflammatory disease with major negative impact on quality of life and significant co-morbidities. This is an important link to insights into immune dysfunction, which stimulated therapeutic approaches like tumor necrosis-α inhibitor therapy. This new off-label drug treatment is particularly beneficial when used in combination with wide excision of inflamed skin and subcutaneous tissue. Retinoids have been reported to be helpful in secondary prevention. The standard of therapy in advanced cases is surgery with wide excisions and healing by secondary intention. This treatment results in significant reduction of complaints and achieves satisfactory body contouring.
  24,266 1,856 16
DRUG PROFILE
Topical rapamycin (sirolimus) for facial angiofibromas
Bhushan Madke
January-March 2013, 4(1):54-57
DOI:10.4103/2229-5178.105488  PMID:23439391
Rapamycin (sirolimus) is a fungal fermentation product that inhibits the proper functioning of a serine/threonine protein kinase in mammalian cells eponymously named mammalian target of rapamycin, or mTOR. Rapamycin is a novel class of anticancer and immunosuppressant drugs targeting the proteins at molecular level. Rapamycin (sirolimus) is routinely incorporated in drug-eluting stents used for cardiac angioplasty. In recent years, rapamycin was found to be efficacious in managing the symptom complex of tuberous sclerosis, i.e. renal angiomyolipoma, giant cell astrocytoma and pulmonary lymphangiomyomatosis. Various investigators have also proved that topically applied rapamycin causes regression of facial angiofibromas, giving better cosmetic results.
  12,337 1,395 17
CASE REPORTS
Ashy dermatosis in an 8-year-old Indian child
Chitralekha Keisham, Rashmi Sarkar, VK Garg, Shikha Chugh
January-March 2013, 4(1):30-32
DOI:10.4103/2229-5178.105466  PMID:23439983
Ashy dermatosis is a disorder of pigmentation, characterized by asymptomatic symmetric ashy gray-colored macules, in the first to third decade of life. It can, however, affect children sometime. But, there is a paucity of similar cases in Indian children. We present a case of ashy dermatosis in an 8-year-old Indian girl who presented to skin OPD with areas of ashy pigmentation, which were distributed symmetrically. Skin biopsy was consistent with lichenoid pattern histology. This case has been reported to highlight the rarity of ashy dermatosis in Indian children.
  11,895 613 2
REVIEW ARTICLES
Clinical variants, stages, and management of basal cell carcinoma
Lyubomir A Dourmishev, Darena Rusinova, Ivan Botev
January-March 2013, 4(1):12-17
DOI:10.4103/2229-5178.105456  PMID:23439912
Basal cell carcinoma (BCC) is the most common paraneoplastic disease among human neoplasms. The tumor affects mainly photoexposed areas, most often in the head and seldom appears on genitalia and perigenital region. BCC progresses slowly and metastases are found in less than 0.5% of the cases; however, a considerable local destruction and mutilation could be observed when treatment is neglected or inadequate. Different variants as nodular, cystic, micronodular, superficial, pigment BCC are described in literature and the differential diagnosis in some cases could be difficult. The staging of BCC is made according to Tumor, Node, Metastasis (TNM) classification and is essential for performing the adequate treatment. Numerous therapeutic methods established for treatment of BCC, having their advantages or disadvantages, do not absolutely dissolve the risk of relapses. The early diagnostics based on the good knowledge and timely organized and adequate treatment is a precondition for better prognosis. Despite the slow progress and numerous therapeutic methods, the basal cell carcinoma should not be underestimated.
  8,516 1,105 12
ORIGINAL ARTICLES
Clinicoepidemiological study of skin manifestations in patients of chronic renal failure on hemodialysis
Supriya P Deshmukh, Yugal K Sharma, Kedarnath Dash, Nitin C Chaudhari, Kirti S Deo
January-March 2013, 4(1):18-21
DOI:10.4103/2229-5178.105458  PMID:23439945
Background: Chronic renal failure (CRF) is associated with a variety of cutaneous manifestations as a result of underlying etiology as well as the various treatment modalities. Aim: To evaluate the prevalence of various dermatoses in patients with CRF on hemodialysis and to study the effect of hemodialysis on the intensity of pruritus. Materials and Methods: A total of 35 patients of CRF on hemodialysis having at least one cutaneous manifestation were included in the study. Results: Twenty-four (68.71%) cases in our study belonged to the age group of 50-69 years, out of which 16 cases were in the sixth decade. Xerosis and pruritus occurred in 80% and 65.71% of cases, respectively. Other common findings included pallor (68.57%), dyspigmentation (34.29%), cutaneous infections (34.39%), acquired perforating dermatosis (17.4%), and nail changes (60%). Hemodialysis failed to improve pruritus in 17 (73.9%) of our patients. Twenty-six patients (74.28%) suffered from hypertension, 13 of them also were known cases of type II diabetes mellitus. Five patients suffered exclusively from type II diabetes mellitus. Conclusions: In our small study, xerosis was the commonest finding and pruritus, the commonest symptom. The intensity of pruritus was largely unaffected by hemodialysis.
  6,724 725 4
Clinical study of Tinea capitis in Northern Karnataka: A three-year experience at a single institute
Varadraj V Pai, Keloji Hanumanthayya, Raghavendra S Tophakhane, Namrata W Nandihal, Naveen Narayan Shetty Kikkeri
January-March 2013, 4(1):22-26
DOI:10.4103/2229-5178.105461  PMID:23439970
Background: Tinea capitis is a superficial fungal infection of the hair follicle of scalp. Most of the dermatophytosis do not have such age propensity as tinea capitis which almost invariably involves the paediatric age group. The exact incidence of tinea capitis is not known. This study is done in order to isolate the species variation in an area, to know the changing patterns of occurrence of different species and their association with clinical pattern Materials and Methods: All clinically diagnosed cases of tinea capitis which presented to our out patient department over a period of one year were included in the study. Results: 70 cases of Tinea capitis were studied. Discussion: Tinea capitis is a disease of prepubertal children with common in age group of 5- 15 years. The incidence varies from 0.5% to 10%. Most common presenting feature was alopecia.
  5,119 607 6
CASE REPORTS
A rare case of keloidal granuloma faciale with extra-facial lesions
Satyendra Kumar Singh, Tulika Rai, Taniya Sharma
January-March 2013, 4(1):27-29
DOI:10.4103/2229-5178.105464  PMID:23439975
Granuloma faciale (GF) is an uncommon, cutaneous disorder characterized by one to several soft, erythematous to livid papules, plaques, or nodules, usually occurring on the face. Extra-facial lesions occur rarely. We present a case report of 33-year-old male who presented with keloidal lesions on face and left shoulder. The patient didn't respond with intralesional triamcinolone and showed poor response with the addition of topical tacrolimus. Surgical excision in consultation with plastic surgeons is planned.
  4,843 314 2
LETTERS TO THE EDITOR
Idiopathic scrotal calcinosis: Is cytological diagnosis enough?
Indranil Chakrabarti, Sidhi R Sharma
January-March 2013, 4(1):58-59
DOI:10.4103/2229-5178.105490  PMID:23437426
  4,484 417 2
CASE REPORTS
Lethal midline granuloma
Varuna Mallya, Avninder Singh, Manish Pahwa
January-March 2013, 4(1):37-39
DOI:10.4103/2229-5178.105469  PMID:23440011
Lethal midline granuloma is a relatively rare disease characterized by destruction and mutilation of the nose and other structures of respiratory passages. The nonspecificity of symptoms obscures the correct diagnosis and is responsible for the delay in treatment which can be detrimental as this grave disease calls for urgent intervention. We present a case report of this disease in a 35 year old male who gave a short two month history of the clinical symptoms.
  4,129 602 5
Ichthyosis hystrix
Surajit Nayak, Basanti Acharjya, Prasenjit Mohanty
January-March 2013, 4(1):47-49
DOI:10.4103/2229-5178.105483  PMID:23440302
The present report describes the condition in a three day old male child with bilateral ,linear, hyperpigmented and hyperkeratotic verrucous plaques and patchy alopecia over scalpe without any nail and skeletal abnormalities. It was suggestive of ichthyosis hystrix type of epidermal nevus,and is being reported in view of the rarity of this condition.
  3,980 412 -
Dermatopathia pigmentosa reticularis: A rare reticulate pigmentary disorder
Vinay Shanker, Mudita Gupta
January-March 2013, 4(1):40-42
DOI:10.4103/2229-5178.105470  PMID:23440032
Dermatopathia pigmentosa reticularis is a rare ectodermal dysplasia with a triad of generalized reticulate hyperpigmentation, noncicatricial alopecia, and onychodystrophy. We report a case of a 21 year old woman who had generalized reticulate pigmentation, diffuse noncicatricial alopecia and onychodystrophy of finger and toe nails. Along with this triad she had palmoplantar keratoderma and poorly developed dermatoglyphics. There was no evidence of involvement of other ectodermally derived organ.
  3,967 412 1
Granular cell tumor of hand presenting as subcutaneous nodule mimicking dermal adnexal tumor: A diagnosis by cytology
Jitendra G Nasit, Sanjaykumar Chauhan, Gauravi Dhruva
January-March 2013, 4(1):33-36
DOI:10.4103/2229-5178.105467  PMID:23439997
Granular cell tumor (GCT) is an uncommon tumor and is believed to be of schwannian origin. GCT is benign but rare malignant cases are recorded. GCT occurs in almost any part of the body. The common sites are the tongue, skin, and subcutaneous tissue. GCT of hand is an extremely rare. Till date only 17 cases are reported in the literature. Preoperative diagnosis of GCT is important, because GCT mimics dermal adnexal tumor in subcutaneous tissue, other soft tissue tumor or inflammatory lesions. GCT is composed of large polygonal cells with eosinophilic granular cytoplasm and these cells are often immunoreactive for the S-100 protein. Fine-needle aspiration cytology has been suggested to be diagnostic modality of choice and this would undoubtedly aid the correct diagnosis. Excision with wide surgical margins is curative for benign GCT. Recurrence and malignant transformation requires regular follow-up. Here, this communication documents a case of cytological diagnosis of the granular cell tumor of hand in a 21-year-old female, clinically suspected to be a dermal adnexal tumor.
  3,982 387 -
CASES FROM ACKERMAN ACADEMY
Central centrifugal cicatricial alopecia
Collin Blattner, Dennis C Polley, Frank Ferritto, Dirk M Elston
January-March 2013, 4(1):50-51
DOI:10.4103/2229-5178.105484  PMID:23440368
Central centrifugal cicatricial alopecia is a common cause of progressive permanent apical alopecia. This unique form of alopecia includes entities previously know as "hot comb alopecia," "follicular degeneration syndrome," "pseudopelade" in African Americans and "central elliptical pseudopelade" in Caucasians. The etiology appears to be multifactorial and the condition occurs in all races.
  3,318 415 1
THROUGH THE LENS
Recurrent dermatofibrosarcoma protuberans: A continuing problem
Manisha Makkar, Dayal Partap Singh, Akshay Rana, Mayank Madan
January-March 2013, 4(1):68-69
DOI:10.4103/2229-5178.105496  PMID:23437433
  3,204 297 1
LETTERS TO THE EDITOR
Polymorphic pityriasis rosea precipitating psoriasis
Sarvajnamurthy Sacchidanand, Suryanarayan Shwetha, Dipali D Malvankar, Mallaiah Mallikarjuna
January-March 2013, 4(1):63-64
DOI:10.4103/2229-5178.105494  PMID:23437430
  2,682 286 -
SKINDIA QUIZ
SkIndia Quiz 8: Multiple subcutaneous swellings around the ears
Biju Vasudevan, Rajesh Verma, Vijendran Pragasam, Nikhil Moorchung, Debdeep Mitra, Shekar Neema
January-March 2013, 4(1):66-67
DOI:10.4103/2229-5178.101816  PMID:23437432
  2,221 356 -
CASE REPORTS
Pyoderma gangrenosum with an underlying ulcerative colitis associated with bone tuberculosis
Milind A Patvekar, Neha C Virmani
January-March 2013, 4(1):43-46
DOI:10.4103/2229-5178.105473  PMID:23440150
Pyoderma gangrenosum is a rare noninfective neutrophilic dermatosis, characterized by progressive painful ulceration. It is frequently associated with systemic disorders like inflammatory bowel disease, rheumatoid arthritis and myeloproliferative diseases. However, its association with infectious diseases in particular with tuberculosis is extremely rare. Diagnosis is based on the history of an underlying disease, a typical clinical presentation, histopathology and exclusion of other diseases leading to ulcerations of similar appearance. Immunosuppression with corticosteroids remains the mainstay of treatment. We report a case of a 49-year-old male with long-standing ulcerative colitis, associated with tuberculosis of hip, who presented with nonhealing ulcers over the lower extremity.
  2,080 283 1
EDITORIAL
Indian Dermatology Online Journal (IDOJ) in 2012 and Beyond
Shyam Verma
January-March 2013, 4(1):1-1
DOI:10.4103/2229-5178.105452  PMID:23437424
  1,910 366 -
LETTERS TO THE EDITOR
Prevalence of cholinergic urticaria in Indian adults
Kiran Godse, Shaista Farooqui, Nitin Nadkarni, Sharmila Patil
January-March 2013, 4(1):62-63
DOI:10.4103/2229-5178.105493  PMID:23437429
  1,756 358 6
Carbamazepine induced severe cutaneous vasculitis
Rameshwar M Gutte, Gautum Tripathi
January-March 2013, 4(1):60-61
DOI:10.4103/2229-5178.105491  PMID:23437427
  1,742 299 2
Detection of P53 and Mdm2 in vitiligo
Viroj Wiwanitkit
January-March 2013, 4(1):61-62
DOI:10.4103/2229-5178.105492  PMID:23437428
  868 256 -
To the editor: Is this cutaneous angiomyolipoma truly an angiomyolipoma?
Krzysztof Okon, Grzegorz Dyduch
January-March 2013, 4(1):65-65
DOI:10.4103/2229-5178.105495  PMID:23437431
  882 220 -
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