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  Indian J Med Microbiol
 

Figure 2: (a) Scanner view showing a cellular multinodular tumor, involving dermis and subcutis (H and E, ×10). (b) A cellular, multinodular tumor below epidermis that shows acanthosis and focal elongation of rete ridges (H and E, ×40). (c) Tumor composed of spindle-shaped cells exhibiting moderate to marked nuclear pleomorphism, with interspersed typical and atypical mitotic figures (inset) (H and E, ×100). (d) Immunohistochemical findings. Diffuse, strong H-caldesmon positivity within tumor cells in the dermis and subcutis. Overlying epidermis marked with arrows heads (diaminobenzidine, ×10). (e) Immunohistochemical findings. Diffuse, moderate smooth muscle actin (SMA) positivity within tumor cells, below epidermis (arrows heads). A predominant vascular pattern suggests the subcutaneous variant of leiomyosarcoma (diaminobenzidine, ×40)

Figure 2: (a) Scanner view showing a cellular multinodular tumor, involving dermis and subcutis (H and E, ×10). (b) A cellular, multinodular tumor below epidermis that shows acanthosis and focal elongation of rete ridges (H and E, ×40). (c) Tumor composed of spindle-shaped cells exhibiting moderate to marked nuclear pleomorphism, with interspersed typical and atypical mitotic figures (inset) (H and E, ×100). (d) Immunohistochemical findings. Diffuse, strong H-caldesmon positivity within tumor cells in the dermis and subcutis. Overlying epidermis marked with arrows heads (diaminobenzidine, ×10). (e) Immunohistochemical findings. Diffuse, moderate smooth muscle actin (SMA) positivity within tumor cells, below epidermis (arrows heads). A predominant vascular pattern suggests the subcutaneous variant of leiomyosarcoma (diaminobenzidine, ×40)