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  Indian J Med Microbiol
 

Figure 11: Hypothesis of intracellular high inducibility to high-carb low-protein diet leading to triggered signals in favor of deregulated autophagy: The process is chiefly determined by type of food available to cells; high protein food triggers mTOR signals which further stimulate ribosomal signals for protein translation while high-carb food triggers insulin signals to down regulate mTOR signals in yeasts, plants, and mammals,[18],[19] which shuts down desired autophagy and subsequently stimulates deregulated autophagy as demonstrated in figure. Similar signals are sent in hypoxia, prolonged starvation, and reduced ATP levels inside cells to control cell homeostasis as per availability of nutrients. Interestingly nutrigenomics is the upcoming field which highlights epigenetic phenomenon of modifiable genes through right nutrition.[21],[22]

Figure 11: Hypothesis of intracellular high inducibility to high-carb low-protein diet leading to triggered signals in favor of deregulated autophagy: The process is chiefly determined by type of food available to cells; high protein food triggers mTOR signals which further stimulate ribosomal signals for protein translation while high-carb food triggers insulin signals to down regulate mTOR signals in yeasts, plants, and mammals,<sup>[18],[19]</sup> which shuts down desired autophagy and subsequently stimulates deregulated autophagy as demonstrated in figure. Similar signals are sent in hypoxia, prolonged starvation, and reduced ATP levels inside cells to control cell homeostasis as per availability of nutrients. Interestingly nutrigenomics is the upcoming field which highlights epigenetic phenomenon of modifiable genes through right nutrition.<sup>[21],[22]</sup>