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  Indian J Med Microbiol
 

Figure 1: Type I/II cytokine receptors lack intrinsic kinase activity and signal through the cytoplasmic Janus kinases (JAK1, JAK2, JAK3, and TYK2) along with the DNA-binding proteins called signal transducers and activators of transcription (STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, and STAT6). Upon engagement of extracellular ligands with the receptors, intracellular JAK proteins become activated and phosphorylate STAT proteins which dimerize and translocate to the nucleus to regulate gene expression. Jakinibs interfere with the cytokine signal transduction to bring about their antiinflammatory effects

Figure 1: Type I/II cytokine receptors lack intrinsic kinase activity and signal through the cytoplasmic Janus kinases (JAK1, JAK2, JAK3, and TYK2) along with the DNA-binding proteins called signal transducers and activators of transcription (STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, and STAT6). Upon engagement of extracellular ligands with the receptors, intracellular JAK proteins become activated and phosphorylate STAT proteins which dimerize and translocate to the nucleus to regulate gene expression. Jakinibs interfere with the cytokine signal transduction to bring about their antiinflammatory effects