• Users Online: 1466
  • Print this page
  • Email this page


 
  Table of Contents  
CASE REPORT
Year : 2013  |  Volume : 4  |  Issue : 4  |  Page : 292-295  

Two cases of giant pyogenic granuloma of scalp


Department of Dermatology, Bhaskar Medical College, Yenkapally, Hyderabad, Andhra Pradesh, India

Date of Web Publication28-Oct-2013

Correspondence Address:
B Satish Chandra
H. No. G8, Trinity Residency, Gandamguda, Golconda (Post), Rajendranagar Mandal, Hyderabad, Andhra Pradesh
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2229-5178.120640

Rights and Permissions
   Abstract 

Pyogenic granuloma is a benign vascular tumor of unknown etiology, though multiple factors play a role in its onset, e.g., trauma, chronic irritation, drugs etc., It is commonly seen in children and adolescents. Giant pyogenic granuloma is its atypical variant. We are presenting two cases of giant pyogenic granuloma, one, in a 28-year-old adult, presenting as a giant fluffy swelling of scalp and the other in a 11-year-old child, presenting as a giant ulcerated globular swelling of the scalp.

Keywords: Lobular capillary hemangioma, pyogenic granuloma, vascular tumors


How to cite this article:
Chandra B S, Rao P N. Two cases of giant pyogenic granuloma of scalp. Indian Dermatol Online J 2013;4:292-5

How to cite this URL:
Chandra B S, Rao P N. Two cases of giant pyogenic granuloma of scalp. Indian Dermatol Online J [serial online] 2013 [cited 2021 Sep 25];4:292-5. Available from: https://www.idoj.in/text.asp?2013/4/4/292/120640


   Introduction Top


Pyogenic granuloma (PG) also known as granuloma telangiectaticum is a benign vascular tumor commonly seen in infants and children but can also occur in adults, particularly in pregnant women. Although the exact cause is not known, possible inciting agents are trauma, chronic irritation, drugs, e.g., retinoid, mitozantrone, indinavir, and erythropoietin. It usually presents as a solitary, red, rapidly growing papule or a nodule. Giant PG variant is very rare. Here we are presenting two cases of giant PG occurring on scalp.


   Case Report Top


Case 1

A 28-year-old male presented with a dirty white colored fluffy swelling on the scalp of 10 days duration. Patient had a history of a scalp injury in a road traffic accident 17 days back, for which suturing was done at a private clinic. Patient did not clean the wound or wash scalp for the next 17 days. Sutures were not removed. He developed an asymptomatic swelling at the same site about 10 days after suturing which gradually grew in size. On cutaneous examination, a friable dirty cream white colored, soft, multi-lobular hemispherical swelling of 4 cm × 4 cm was seen on the left fronto parietal area of scalp [Figure 1]. On palpation, the swelling was non-tender and the base was adherent to the scalp, with bleeding from the base on manipulation. On firm pressure, the swelling was yielding and breaking like a empty gelatinous egg shell. Differential diagnosis considered were: Foreign body reaction to retained sutures, PG and mucormycosis, squamous cell carcinoma.
Figure 1: Clinical photograph of Patient 1 showing dirty white colored, soft, multi lobular hemispherical swelling of giant PG on the left fronto-parietal area of scalp

Click here to view


Patient was negative for serologica l test for HIV and syphilis. Other routine investigations were with in normal limits. Scraping for fungal filaments and fungal culture were negative. Biopsy from the swelling revealed focally ulcerated epidermis with ulcerated area showing granulation tissue with proliferating fibroblasts and blood vessels [Figure 2]. Dense inflammation composed of lymphocytes, plasma cells, few PMN, and eosinophils. No evidence of granuloma or neoplasm was observed. Pathologist opined that it was a reactive pattern similar to PG with ulceration and exuberant granulation tissue amid dense acute-on-chronic inflammation.
Figure 2: Histopathology of patient 1 showing loss of epidermis (ulceration) with vascular clefts, hemorrhage, lymphocytic, and PMN infiltrate along with epidermal strands into the cavity of tumor (H and E, ×100)

Click here to view


Patient was given systemic antibiotics, oral metronidazole, and topical betadine. The swelling regressed gradually in size over a period of 5 weeks, leaving behind an adherent crust. Sutures were removed by removing the crust only after swelling regressed completely.

Case 2

A 11-year-old child presented with complaints of a globular swelling with ulcerated surface and slight sero-sanguineous discharge over the occipital region of scalp of 2 months duration. There was a history of injury at that site 2 weeks prior to the onset of swelling, for which an ayurvedic paste was applied. A local practitioner attempted unsuccessfully to excise the swelling. After 10 days the patient again sustained an injury at the same site after which the lesion started to grow rapidly and in about 1 month time it grew to the size of 4 cm × 5 cm with ulcerated surface and sero-sanguineous discharge. There was slight itching on the swelling but no pain.

On examination, a lobulated swelling 4 cm × 5 cm with a erythematous glistening surface with patchy necrotic areas covered with yellowish-brown crust along with adherent cotton was observed on vertex of the scalp [Figure 3]. On palpation the swelling was soft, non tender, slightly mobile in both directions with mild sero-sanguineous discharge which increased on firm pressure. Posterior and anterior group of cervical lymph nodes were enlarged. General examination of the patient was normal. Differential diagnosis considered were deep fungal infections, squamous cell carcinoma. Routine investigations were under normal limits. Discharge for fungal filaments and fungal culture were negative. Serological tests for HIV and syphilis were non-reactive.
Figure 3: Clinical photograph of patient 2 showing a giant PG with ulcerated surface and un-healthy granulation tissue with lumps of dried up cotton gauze on the left parieto-occipital region of the scalp

Click here to view


An excisional biopsy of the entire lesion was done. Histopathology showed a lobular capillary hemangioma [Figure 4]. Patient was reviewed at one and four weeks and the surgical site healed without any recurrence.
Figure 4: Histopathology of patient 2 showing fibrous background with numerous interconnected vascular channels filled with RBC, suggestive of lobular capillary hemangioma (H and E, ×400)

Click here to view



   Discussion Top


The term PG is a misnomer, as it is neither infectious nor granulomatous in nature. It is common in children and unusual in elderly. Its prevalence peaks in second decade of life. [1] PG usually present as a solitary, rapidly growing, red papule or nodule, usually painless, with propensity to bleed spontaneously or with manipulation. Most of the cases have a history of trauma. PG of skin is more common in males, while mucosal occurrence is more common in females. ''Granuloma gravidarum'' or pregnancy tumor, which is a PG of oral cavity, commonly seen in second or third trimester is the most common mucosa l variety. [2] The commonly involved sites on skin are peri-ungal area of fingers, the feet, lips, head and upper trunk and perianal area, although sites such as scalp is also reported. [3]

The actual mechanism for the development of PG is not known. Trauma, hormonal influences, viral oncogenes, underlying microscopic arterio-venousus malformations plays their role. PG were reported after the use of oral and topical retinoid, [4] indinavir, [5] erythropoietin, systemic 5-flurouracil, and mitozantrone. [6] PG was reported in pre-existing nevus flammeus and spider angiomas and developed at the site of cherry angioma treated with pulsed-dye laser. [7] The production of angiogenic factors, cytogenetic abnormalities and over expression of transcription factors P-ATF2 and STAT3 were found to have a role in its development. [8]

Typically, PG grows rapidly for a few weeks and then stabilizes at a size of about 2 cm in diameter, although larger swellings (giant PG) are known to occur. [3],[9] Early lesions have a thin intact epidermis, but older lesions are frequently eroded and crusted and may bleed very easily. Occasionally, the surface can be verrucous. In patient 1 of this report, the surface was dirty white in color, which is unusual and not reported till now, while in the second patient, the surface was glistening red with partial crusting. The base of the PG was sessile in the first patient, [10] while it was pedunculated in the second, with both varieties being reported in literature. Giant PGs, although infrequent, were reported in literature. A Giant PG was reported at the site of scar in a HIV-patient. [11] A case of giant PG of scalp was reported in a pregnant woman after an injury to scalp. [3] In the present report, it appeared at the site of injury on the scalp in both the patients and grew to become a giant PG.

In typical PG, histopathology shows lobular proliferation of small blood vessels which erupt through a breach in the epidermis to produce a globular pedunculated tumor. In ulcerated lesions a superficial inflammatory cell reaction can give rise to an appearance of a granulation tissue, a mixed cell population of fibroblasts, lymphocytes, plasma cells can be seen. In patient 1 of this report, there was focally ulcerated epidermis showing granulation tissue with proliferating fibroblasts with dense inflammatory infiltrate.

The angiomatous tissue occasionally tends to occur in discrete masses or lobules, resembling a capillary hemangioma; hence, histologically PG is also named as lobular capillary hemangioma. Patient 2 of this report showed typical features of a lobular capillary hemangioma. It was composed of variably dilated network of blood-filled capillary vessels and groups of poorly canalized vascular tufts. Bacillary angiomatosis which clinically and histologically resembles PG can be differentiated on histology as it shows prominent pale epithelioid endothelial cells, neutrophils, and nuclear dust throughout the lesion along with the features of lobular capillary hemangioma. In addition, Giemsa or Warthin-Starry stains demonstrate bacilli which are easily identifiable as violaceous amorphous aggregates.

Various modalities available to treat the PG include curettage and cauterization, coagulation of the base with diathermy, excision and sutures, cryo-therapy with liquid nitrogen or nitrous oxide and lasers.


   Conclusion Top


PG is a common benign vascular tumor seen in children and occasionally in adults, with most of them growing to <2 cm in size. However, in the present report, PGs in both patients grew to a size of >4 cm to be considered as giant PG. In both these patients, the inciting cause was an injury, which was improperly attended initially and later mismanaged. The probable reason for the PG to grow to a giant size in these patients could be due to deep injury of the scalp with secondary foreign body reaction of the tissue, to the suture material in the first case and to indigenous ayurvedic pastes in the second. These two cases of giant PG of the scalp are being reported for their rarity.

 
   References Top

1.Knoth W, Ehlers G. On the problem of the existence of telangiectatic pyogenic granuloma with special reference to its relations to hemangioma and hemangioendothelioma. Arch Klin Exp Dermatol 1962;214:394-414.  Back to cited text no. 1
    
2.Harris MN, Desai R, Chuang TY, Hood AF, Mirowski GW. Lobular capillary hemangioma: An epidemiological report, with emphasis on cutaneous lesions. J Am Acad Dermatol 2000;42:1012-6.  Back to cited text no. 2
    
3.Domínguez-Cherit J, Puebla-Miranda M, Rangel-Gamboa L, Roldán-Marín R. Giant gravidarum granuloma of the scalp. Gac Med Mex 2006;142:411-3.  Back to cited text no. 3
    
4.Teknetzis A, Ioannides D, Vakali G, Lefaki I. Pyogenic granulomas following topical application of tretinoin. J Eur Acad Dermatol Venereol 2004;18:337-9.  Back to cited text no. 4
    
5.Bouscarat F, Bouchard C, Bouhour D. Paronychia and pyogenic granuloma of great toes in patients treated with indinavir. N Engl J Med 1998;338:1776-7.  Back to cited text no. 5
    
6.Freiman A, Bouganim N, O'Brien EA. Case reports: Mitozantrone-induced onycholysis associated with subungal abscesses, paronychia, and pyogenic granuloma. J Drugs Dermatol 2005;4:490-2.  Back to cited text no. 6
    
7.Cheah S, DeKoven J. Pyogenic granuloma complicating pulsed-dye laser therapy for cherry angioma. Australas J Dermatol 2009;50:141-3.  Back to cited text no. 7
    
8.Chen SY, Takeuchi S, Urabe K, Urabe K, Hayashida S, Kido M, et al. Overexpression of phosphorylated-ATF2 and STAT3 in cutaneous angiosarcoma and pyogenic granuloma. J Cutan Pathol 2008;35:722-30.  Back to cited text no. 8
    
9.Nthumba PM. Giant pyogenic granuloma of the thigh: A case report. J Med Case Reports 2008;2:95.  Back to cited text no. 9
    
10.Bayakan H, Ozyurt K, Ozkam F, Sen H. Giant Pyogenic granuloma in a renal transplant patient. Eur J Plast Surg 2012.  Back to cited text no. 10
    
11.Mooney MA, Janniger CK. Pyogenic granuloma. Cutis 1995;55:133-6.  Back to cited text no. 11
    


    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4]


This article has been cited by
1 Botriomicoma gigante de localización palmar
María Carolina González-Aspillaga,Carolina Pardo-Zamudio,Felipe Ruiz,Alfredo Cardemil-Van der Schraft,Laura Segovia,Rodrigo Loubies
Piel. 2017;
[Pubmed] | [DOI]
2 Gastrointestinal Pyogenic Granuloma (Lobular Capillary Hemangioma): An Underrecognized Entity Causing Iron Deficiency Anemia
Marshall W. Meeks,Umar M. Kamal,Muhammad B. Hammami,Jason R. Taylor,M. Louay Omran,Yongxin Chen,Jin-Ping Lai
Case Reports in Gastrointestinal Medicine. 2016; 2016: 1
[Pubmed] | [DOI]



 

Top
 
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
    Abstract
   Introduction
   Case Report
   Discussion
   Conclusion
    References
    Article Figures

 Article Access Statistics
    Viewed3461    
    Printed42    
    Emailed0    
    PDF Downloaded298    
    Comments [Add]    
    Cited by others 2    

Recommend this journal