• Users Online: 616
  • Print this page
  • Email this page

  Table of Contents  
Year : 2014  |  Volume : 5  |  Issue : 3  |  Page : 309-311  

Lupus vulgaris of the glans penis: A rare presentation

Department of Dermatology, STD and Leprosy, Bangalore Medical College and Research Institute, Bangalore, Karnataka, India

Date of Web Publication31-Jul-2014

Correspondence Address:
Sathish Shankar
No. 52, OPD 'B' Block, Department of Dermatology, STD and Leprosy, Victoria Hospital, Fort, Bangalore - 560 002, Karnataka
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2229-5178.137785

Rights and Permissions

Tuberculosis of the penis is a rare presentation that may present as ulcers, papules, or nodules on the glans or shaft of penis. Herein we report one such case.

Keywords: Cutaneous tuberculosis, glans penis, lupus vulgaris

How to cite this article:
Aradhya SS, Shankar S. Lupus vulgaris of the glans penis: A rare presentation. Indian Dermatol Online J 2014;5:309-11

How to cite this URL:
Aradhya SS, Shankar S. Lupus vulgaris of the glans penis: A rare presentation. Indian Dermatol Online J [serial online] 2014 [cited 2021 Sep 27];5:309-11. Available from: https://www.idoj.in/text.asp?2014/5/3/309/137785

   Introduction Top

Tuberculosis is a global health problem. [1] Cutaneous tuberculosis is now rarely encountered in the Western countries, but is seen in developing countries where the incidence of tuberculosis is high. [2] Tuberculosis of the glans penis is an extremely rare presentation, with very few cases reported till date. Here, we report a case of lupus vulgaris of the glans penis, which presented in the form of long-standing painful papules.

   Case report Top

A 23-year-old unmarried male patient presented at our OPD with a one-year history of multiple, raised, painful skin lesions on the glans penis. There was no history of remissions or exacerbations, nor any history of sexual exposure. The patient did not have a history of cough, hemoptysis, chest pain, dyspnea, hematuria, pain in abdomen, hematochezia, headache, weight loss, fever, or loss of appetite. There was no history of ulcers over the genitalia, burning micturition, or purulent discharge per urethra. He had undergone circumcision in his childhood as a part of religious practice. On examination, he was moderately built and nourished and afebrile. Four ill-defined, discrete, erythematous, firm, tender, papules were present on the glans penis, two on the dorsum of the glans and the other two on either side of the frenulum [Figure 1]. There were no ulcers, fissures, erythema, or edema over the glans penis and no discharge per urethra. Inguinal lymph nodes and other lymph nodes were not palpable. There were no other skin lesions elsewhere. BCG vaccination scar was visible. Mucosal examination was normal. Other systemic examination was normal. Histopathological examination of intact papule showed epithelioid granulomas consisting of Langhan's giant cells, epithelioid cells, and lymphocytes [Figure 2]. Mantoux test was strongly positive, maximum diameter measuring 35 mm [Figure 3]. Other investigations done to search for any foci of tuberculosis elsewhere in the body like chest radiograph and abdominal and pelvic sonography were normal. Other routine investigations were normal. Enzyme-linked immunosorbent assay (ELISA) for HIV 1 and 2 and venereal disease research laboratory (VDRL) were nonreactive. At this stage, a diagnosis of cutaneous tuberculosis was made, and the patient was started on category 1 antitubercular therapy (ATT) with isoniazid 600 mg, rifampicin 450 mg, pyrazinamide 1500 mg, and ethambutol 1200 mg. The patient was reviewed again after six weeks of starting ATT, and all the lesions had subsided with the treatment; no ulcers or scars were present except for the biopsy scar [Figure 4]. The diagnosis of lupus vulgaris was confirmed and the treatment was continued.
Figure 1: (a) One ill-defined, erythematous papule on the glans penis, (b) Two ill-defined erythematous papules on either side of the attachment of the frenulum to the glans penis

Click here to view
Figure 2: (a) Tuberculoid granuloma consisting of caseous necrosis surrounded by Langhans giant cell, epithelioid cells, lymphocytes, H and E, ×10, (b) Langhans giant cell and lymphocytes, H and E, ×40 (C) Langhans giant cells and epithelioid cells, H and E, ×40

Click here to view
Figure 3: Strongly positive Mantoux test measuring 35 × 35 mm

Click here to view
Figure 4: Photographs taken six weeks after treatment showing complete resolution of the lesions

Click here to view

   Discussion Top

In 1956, Pillsbury, Shelly and Kligman wrote, "In the skin, tuberculosis presents itself in an astonishing variety of forms, which has given rise to an unwieldy, overextended number of descriptive terms and bewildering classifications, almost impossible to grasp except by the most avid dermatologic taxonomist. The potentiality of the skin to react in many different ways to a single disease agent is nowhere better illustrated than in tuberculosis. Every variety of granuloma is represented: plaques, ulcers, verrucous lesions, nodules, papillomatous tumors, vegetative reactions and cicatricial infiltrates. A classification based entirely on the morphology of tuberculous lesions is not possible, since one type of the disease, e.g. lupus vulgaris, may present itself in all these forms."[3] Various classifications have been proposed to classify cutaneous tuberculosis; recently a classification based on the bacterial load was proposed and accordingly classified into multibacillary forms (e.g., scrofuloderma, tuberculous chancre, and acute military tuberculosis) and paucibacillary forms (e.g., lupus vulgaris, tuberculosis verrucosa cutis, tuberculids). [4] In our case, the diagnosis of lupus vulgaris of the glans penis was made based on the presentation of long-standing painful papules on the glans penis, tuberculoid granulomas on histopathology, negative Ziehl-Neelsen stain for acid-fast bacilli (AFB), strongly positive Mantoux test, with no foci of tuberculosis elsewhere in the body, and prompt response to ATT. Polymerase chain reaction (PCR) could not be done as the patient could not afford it. HIV and VDRL were negative, hence ruling out the possibility of syphilitic gumma.

Lupus vulgaris is the most common type of cutaneous tuberculosis and with the most varied manifestations. Lupus vulgaris originates from an underlying focus of tuberculosis, typically in a bone, joint, or lymph node, and arises by either contiguous extension of the disease from the underlying affected tissue or by hematogenous or lymphatic spread. Sometimes, the underlying focus is not clinically apparent, and in such cases, reactivation of a latent cutaneous focus secondary to previous silent bacteremia is postulated. It can also arise after exogenous inoculation like sexual intercourse from a partner.

These patients have a moderate or high degree of immunity against tubercle bacilli. Morphological expressions of lupus vulgaris are innumerable, and every possible variant of a granulomatous process is represented. Buttocks, thighs, and legs are more common sites of involvement in India. [5] Glans penis is an extremely rare site for lupus vulgaris, with very few cases being reported so far. Jaisankar TJ et al. reported a case of penile lupus vulgaris in 1994. [6] Golchai reported a rare presentation of lupus vulgaris on glans penis in a 60-year-old Iranian individual in 1997; the patient had presented with a one-year history of a painful erythematous crusted plaque on the glans penis. [7] Various cases of other forms of tuberculosis like tuberculous chancre and papulonecrotic tuberculids on glans penis have been reported. Dutta et al. in 2001 reported a case of primary tuberculosis of the glans penis in a 47-year-old male who presented with ulcers over the glans which mimicked malignancy. [8] Nath et al. in 2008 reported a case of papulonecrotic tuberculid of the glans penis in a 56-year-old married patient who presented with multiple ulcers. [9] Recently, Kar et al. reported a case of primary tuberculosis over the glans penis in a 31-year-old male patient from Midnapur in August 2012. [10] The presentation of lupus vulgaris on the glans penis is rare, with very few cases being reported till date.

   References Top

1.Styblo K. Overview and epidemiologic assessment of the current global tuberculosis situation with emphasis on control in developing countries. Rev Infect Dis 1989;11(Suppl 2):S339-46.  Back to cited text no. 1
2.O'Brien RJ. The epidemiology of nontuberculous mycobacterial disease. Clin Chest Med 1989;10:407-18.  Back to cited text no. 2
3.Pillsbury DM, Shelley WB, Kligman AM. Dermatology. Philadelphia: WB Saunders; 1956. p. 499-540.  Back to cited text no. 3
4.Tigoulet F, Fournier V, Caumes E. Clinical forms of the cutaneous tuberculosis. Bull Soc Pathol Exot 2003;96:362-7.  Back to cited text no. 4
5.Singh G. Lupus vulgaris in India. Indian J Dermatol Venereol Leprol 1974;40:257-60.  Back to cited text no. 5
  Medknow Journal  
6.Jaisankar TJ, Garg BR, Reddy BS, Riba B, Ramarao AP. Penile lupus vulgaris. Int J Dermatol 1994;33:272-4.  Back to cited text no. 6
7.Golchai J. Tuberculosis of the glans penis. Med J Islam Repub Iran 1997;2:65-6.  Back to cited text no. 7
8.Dutta B, Chatterjee G, Das TK. Primary tuberculosis of the glans penis. Indian J Dermatol 2001;46:245-7.  Back to cited text no. 8
  Medknow Journal  
9.Nath AK, Janakiraman SK, Chougule A, Thappa DM. Penile papulonecrotic tuberculid: Revisited. Indian J Dermatol 2008;53:220-1.  Back to cited text no. 9
[PUBMED]  Medknow Journal  
10.Kar JK, Kar M. Primary Tuberculosis of the Glans Penis. J Assoc Physicians India 2012;60:52-3.  Back to cited text no. 10


  [Figure 1], [Figure 2], [Figure 3], [Figure 4]

This article has been cited by
1 Tuberculosis of the glans penis: an important differential diagnosis of genital ulcer disease
Archana Singal,Deepika Pandhi,Vandana Kataria,Vinod K Arora
International Journal of STD & AIDS. 2017; 28(14): 1453
[Pubmed] | [DOI]
2 Urethrocutaneous fistula: a rare presentation of penile tuberculosis
Neetu Bhari,Banwari L Jangid,Sanjay Singh,Setu Mittal,Firdaus Ali,Savita Yadav
International Journal of STD & AIDS. 2017; 28(1): 97
[Pubmed] | [DOI]
3 Tuberculosis of the glans penis mimicking as carcinoma
Dawood Khan,Arpan Choudhary,Avisek Dutta,Imran Khan
International Journal of Mycobacteriology. 2016;
[Pubmed] | [DOI]


    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

  In this article
   Case report
    Article Figures

 Article Access Statistics
    PDF Downloaded321    
    Comments [Add]    
    Cited by others 3    

Recommend this journal