|LETTER TO THE EDITOR
|Year : 2014 | Volume
| Issue : 5 | Page : 54-55
Buschke-Lowenstein tumor in a patient with decompensated cirrhosis
F. N. U. Shailesh, Nitin Relia, Naga Venkata K Pothineni, Abhishek Agarwal
Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
|Date of Web Publication||13-Nov-2014|
Dr. F. N. U. Shailesh
Department of Internal Medicine, University of Arkansas for Medical Sciences, 4301 W. Markham St., Little Rock, Arkansas 72205
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Shailesh F, Relia N, Pothineni NK, Agarwal A. Buschke-Lowenstein tumor in a patient with decompensated cirrhosis. Indian Dermatol Online J 2014;5, Suppl S1:54-5
|How to cite this URL:|
Shailesh F, Relia N, Pothineni NK, Agarwal A. Buschke-Lowenstein tumor in a patient with decompensated cirrhosis. Indian Dermatol Online J [serial online] 2014 [cited 2021 Mar 3];5, Suppl S1:54-5. Available from: https://www.idoj.in/text.asp?2014/5/5/54/144540
A 57-year-old Caucasian male presented with continuous oozing of blood from a large exophytic growth over the abdomen and penile shaft. The patient reported a slowly enlarging exophytic growth over his penis [Figure 1]a and abdomen [Figure 1]b for past 35 years. He never sought medical attention for these; however, for the past 2 weeks, he was continuously oozing blood from these growths, requiring him to change clothes and bed sheets several times a day. Past medical history was significant for end-stage liver disease from untreated hepatitis C. At presentation, his hemoglobin was 6.6 and INR 1.9. During the course of hospitalization, patient was transfused as needed with reversal of coagulopathy; however the bleeding continued. Biopsy from both abdominal and penile growth showed increased mitosis and atypia, causing push effect, but lacked basement membrane invasion, [Figure 2]a and b consistent with diagnosis of Buschke-Lowenstein tumor (BLT). Our patient failed radiotherapy and surgery was not an option because of decompensated cirrhosis with irreversible coagulopathy.
|Figure 1: (a) Large, exophytic lesions over the penile shaft and scrotum; (b) Large, exophytic lesions on the abdomen|
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|Figure 2: (a and b) Histopathology of lesions illustrates papillomatosis, acanthosis, and keratin pearls with increased mitosis and atypia|
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| Discussion|| |
BLT is a slow-growing cauliflower-like lesion, caused by human papilloma virus types 6 and 11. , It is more common in males, with a male: female ratio of 2.7:1. The mean age of presentation is 44 years. It primarily affects the genital and anorectal regions. The most common presentation is a huge mass causing disfigurement. Others include fistulas, abscess, bleeding, weight loss, pruritus, and anemia. It represents a stage of intermediacy with common wart at one end and invasive squamous cell cancer (verrucous carcinoma) at the other. Histologically, it is similar to condyloma acuminatum, but, with a tendency to compress and displace the deeper tissues, without basement membrane disruption. Malignant transformation occurs in 40-60%  of cases with histological evidence of basement membrane invasion that is then termed as verrucous carcinoma. Although it lacks metastatic potential, its recurrence rate is 70%. 
Early radical surgery with wide excision margins remains the mainstay of treatment and offers a hope of cure.  Various case reports demonstrating successful treatment of BLT with other conservative modalities such as systemic chemotherapy, cryosurgery, podophyllin, topical 5-FU, intralesional bleomycin, 13-cis retinoic acid, imiquimod, CO 2 laser surgery, and interferons , has been reported; but, for larger lesions, these modalities have shown limited efficacy, making early radical surgery with wide excision the treatment of choice. ,
This patient was deemed to be a non-operative candidate because of underlying cirrhosis and irreversible coagulopathy. The patient received palliative radiation to the lesions, which was complicated by further bleeding, and was finally discharged to hospice care.
| References|| |
Trottier H, Burchell AN. Epidemiology of mucosal human papillomavirus infection and associated diseases. Public Health Genomics 2009;12:291-307.
Aubin F, Prétet JL, Jacquard AC, Saunier M, Carcopino X, Jaroud F, et al
. EDiTH Study Group. Human papillomavirus genotype distribution in external acuminata condylomata: A large French national study (EDiTH IV). Clin Infect Dis 2008;47:610-5.
Papiu HS, Dumnici A, Olariu T, Onita M, Hornung E, Goldis D, et al
. Perianal giant condyloma acuminatum (Buschke-Löwenstein tumor). Case report and review of the literature. Chirurgia (Bucur) 2011;106:535-9.
Jablonska S. Traditional therapies for the treatment of condylomata acuminata (genital warts). Australas J Dermatol 1998;39 Suppl 1:S2-4.
Gholam P, Enk A, Hartschuh W. Successful surgical management of giant condyloma acuminatum (Buschke-Löwenstein tumor) in the genitoanal region: A case report and evaluation of current therapies. Dermatology 2009;218:56-9.
Radovanovic Z, Radovanovic D, Semnic R, Nikin Z, Petrovic T, Kukic B. Highly aggressive Buschke-löwenstein tumor of the perineal region with fatal outcome. Indian J Dermatol Venereol Leprol 2012;78:648-50.
[Figure 1], [Figure 2]