• Users Online: 2245
  • Print this page
  • Email this page

  Table of Contents  
Year : 2014  |  Volume : 5  |  Issue : 5  |  Page : 54-55  

Buschke-Lowenstein tumor in a patient with decompensated cirrhosis

Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

Date of Web Publication13-Nov-2014

Correspondence Address:
Dr. F. N. U. Shailesh
Department of Internal Medicine, University of Arkansas for Medical Sciences, 4301 W. Markham St., Little Rock, Arkansas 72205
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2229-5178.144540

Rights and Permissions

How to cite this article:
Shailesh F, Relia N, Pothineni NK, Agarwal A. Buschke-Lowenstein tumor in a patient with decompensated cirrhosis. Indian Dermatol Online J 2014;5, Suppl S1:54-5

How to cite this URL:
Shailesh F, Relia N, Pothineni NK, Agarwal A. Buschke-Lowenstein tumor in a patient with decompensated cirrhosis. Indian Dermatol Online J [serial online] 2014 [cited 2021 Dec 8];5, Suppl S1:54-5. Available from: https://www.idoj.in/text.asp?2014/5/5/54/144540


A 57-year-old Caucasian male presented with continuous oozing of blood from a large exophytic growth over the abdomen and penile shaft. The patient reported a slowly enlarging exophytic growth over his penis [Figure 1]a and abdomen [Figure 1]b for past 35 years. He never sought medical attention for these; however, for the past 2 weeks, he was continuously oozing blood from these growths, requiring him to change clothes and bed sheets several times a day. Past medical history was significant for end-stage liver disease from untreated hepatitis C. At presentation, his hemoglobin was 6.6 and INR 1.9. During the course of hospitalization, patient was transfused as needed with reversal of coagulopathy; however the bleeding continued. Biopsy from both abdominal and penile growth showed increased mitosis and atypia, causing push effect, but lacked basement membrane invasion, [Figure 2]a and b consistent with diagnosis of Buschke-Lowenstein tumor (BLT). Our patient failed radiotherapy and surgery was not an option because of decompensated cirrhosis with irreversible coagulopathy.
Figure 1: (a) Large, exophytic lesions over the penile shaft and scrotum; (b) Large, exophytic lesions on the abdomen

Click here to view
Figure 2: (a and b) Histopathology of lesions illustrates papillomatosis, acanthosis, and keratin pearls with increased mitosis and atypia

Click here to view

   Discussion Top

BLT is a slow-growing cauliflower-like lesion, caused by human papilloma virus types 6 and 11. [1],[2] It is more common in males, with a male: female ratio of 2.7:1. The mean age of presentation is 44 years. It primarily affects the genital and anorectal regions. The most common presentation is a huge mass causing disfigurement. Others include fistulas, abscess, bleeding, weight loss, pruritus, and anemia. It represents a stage of intermediacy with common wart at one end and invasive squamous cell cancer (verrucous carcinoma) at the other. Histologically, it is similar to condyloma acuminatum, but, with a tendency to compress and displace the deeper tissues, without basement membrane disruption. Malignant transformation occurs in 40-60% [3] of cases with histological evidence of basement membrane invasion that is then termed as verrucous carcinoma. Although it lacks metastatic potential, its recurrence rate is 70%. [4]

Early radical surgery with wide excision margins remains the mainstay of treatment and offers a hope of cure. [5] Various case reports demonstrating successful treatment of BLT with other conservative modalities such as systemic chemotherapy, cryosurgery, podophyllin, topical 5-FU, intralesional bleomycin, 13-cis retinoic acid, imiquimod, CO 2 laser surgery, and interferons [4],[6] has been reported; but, for larger lesions, these modalities have shown limited efficacy, making early radical surgery with wide excision the treatment of choice. [5],[6]

This patient was deemed to be a non-operative candidate because of underlying cirrhosis and irreversible coagulopathy. The patient received palliative radiation to the lesions, which was complicated by further bleeding, and was finally discharged to hospice care.

   References Top

Trottier H, Burchell AN. Epidemiology of mucosal human papillomavirus infection and associated diseases. Public Health Genomics 2009;12:291-307.  Back to cited text no. 1
Aubin F, Prétet JL, Jacquard AC, Saunier M, Carcopino X, Jaroud F, et al. EDiTH Study Group. Human papillomavirus genotype distribution in external acuminata condylomata: A large French national study (EDiTH IV). Clin Infect Dis 2008;47:610-5.  Back to cited text no. 2
Papiu HS, Dumnici A, Olariu T, Onita M, Hornung E, Goldis D, et al. Perianal giant condyloma acuminatum (Buschke-Löwenstein tumor). Case report and review of the literature. Chirurgia (Bucur) 2011;106:535-9.  Back to cited text no. 3
Jablonska S. Traditional therapies for the treatment of condylomata acuminata (genital warts). Australas J Dermatol 1998;39 Suppl 1:S2-4.  Back to cited text no. 4
Gholam P, Enk A, Hartschuh W. Successful surgical management of giant condyloma acuminatum (Buschke-Löwenstein tumor) in the genitoanal region: A case report and evaluation of current therapies. Dermatology 2009;218:56-9.  Back to cited text no. 5
Radovanovic Z, Radovanovic D, Semnic R, Nikin Z, Petrovic T, Kukic B. Highly aggressive Buschke-löwenstein tumor of the perineal region with fatal outcome. Indian J Dermatol Venereol Leprol 2012;78:648-50.  Back to cited text no. 6
[PUBMED]  Medknow Journal  


  [Figure 1], [Figure 2]


    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

  In this article
    Article Figures

 Article Access Statistics
    PDF Downloaded175    
    Comments [Add]    

Recommend this journal