|
 |
| THROUGH THE LENS |
|
| Year : 2014 | Volume
: 5
| Issue : 5 | Page : 56-57 |
|
|
Multiple papulonodular lesions located over the nasolabial sulcus
Ayse Serap Karadag1, Emin Ozlu1, Ebru Zemheri2, Seyma Ozkanli2
1 Department of Dermatology, Istanbul Medeniyet University, Faculty of Medicine, Goztepe Research and Training Hospital, Istanbul, Turkey
2 Department of Pathology, Istanbul Medeniyet University, Faculty of Medicine, Goztepe Research and Training Hospital, Istanbul, Turkey
| Date of Web Publication | 13-Nov-2014 |
Correspondence Address:
Dr. Ayse Serap Karadag
Department of Dermatology, Istanbul Medeniyet University, Faculty of Medicine, Goztepe Research and Training Hospital, Istanbul
Turkey
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/2229-5178.144543
How to cite this article:
Karadag AS, Ozlu E, Zemheri E, Ozkanli S. Multiple papulonodular lesions located over the nasolabial sulcus. Indian Dermatol Online J 2014;5, Suppl S1:56-7 |
How to cite this URL:
Karadag AS, Ozlu E, Zemheri E, Ozkanli S. Multiple papulonodular lesions located over the nasolabial sulcus. Indian Dermatol Online J [serial online] 2014 [cited 2020 Dec 5];5, Suppl S1:56-7. Available from: https://www.idoj.in/text.asp?2014/5/5/56/144543 |
A 54-year-old woman presented with multiple, skin colored, papulonodular lesions located on nose and nasolabial sulcus since 30 years. There were no other cutaneous lesions. A systemic examination was normal. There was a history of similar lesions on the face of one sister and two brothers. There was no history of consanguinity.
Dermatologic examination showed multiple, skin colored, solid, 1-10 mm grouped papulonodular lesions, especially on the nose and nasolabial sulcus [Figure 1]a and b. Histopathologic examination showed a tumor consisting of multiple nodules within the dermis [Figure 2]a, basaloid epithelial cells with focal follicular differentiation and small horn cysts [Figure 2]b. | Figure 2: (a) Histopathologic photograph in low power (H and E, ×20); (b) better visualization in ×40
Click here to view |
 Discussion | |  |
Trichoepithelioma is a benign trichogenic tumor that may differentiate into follicular pattern. [1],[2] There are two clinical types of trichoepitheliomas: (1) Solitary non-familial type and (2) multiple familial type. The familial type is an autosomal dominant inherited syndrome known as multiple familial trichoepitheliomas or Brook-Fordyce disease. Brook-Fordyce disease is a rare disease and characterized by asymptomatic, multiple, skin colored papulonodular lesions located over the nose, forehead, and nasolabial sulcus. [3]
Multiple trichoepitheliomas may be associated with genetic diseases such as vermiculate atrophoderma, milia, basal cell carcinoma, peripheral cyanosis in Rombo syndrome, basal cell carcinoma, and follicular atrophy in Bazex syndrome. [3] Brook-Spiegler syndrome is an autosomal dominant inherited syndrome including cylindromas, trichoepitheliomas, and occasional eccrine spiradenomas. [3],[4] Inherited multiple trichoepitheliomas can appear in this syndrome.
Multiple familial trichoepithelioma is a benign disease and malignant transformation is very rare. Cosmetic concern forms the main reason for treatment of multiple trichoepitheliomas. [3] There are various treatment modalities, including surgical excision, chemical cauterization, laser resurfacing, electrosurgery, dermabrasion, and topical 5% imiquimod cream. However, these treatments may not be effective. [3]
Brook-Fordyce disease is a very rare syndrome. Thus, patients with histologically proven Brook-Fordyce disease should be investigated for family history and systemic involvement. The accompanied syndromes should be investigated, and if detected, malignancy work-up should be performed.
| References | | |
| 1. | Ying ZX, Ma HQ, Liu Y, Xiao SX, Wang YX, Wang GX. A novel mutation of CYLD in a Chinese family with multiple familial trichoepithelioma. J Eur Acad Dermatol Venereol 2012;26:1420-3.  |
| 2. | Genc S, Sirin Ugur S, Arslan IB, Demir A, Tuhanioglu B, Kuskonmaz I, et al. A giant solitary trichoepithelioma originating from the auricle. Dermatol Surg 2012;38:1527-8. |
| 3. | Kaur T, Puril KJ, Chahal KS, Budhwar J. Multiple familial trichoepitheliomas: A case report and review. J Egypt Dermatol 2012;8:11. |
| 4. | Baykal C, editor. Adnexal neoplasms. Atlas of Dermatology. Turkey: Argos; 2004. |
[Figure 1], [Figure 2]
|
