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Year : 2018  |  Volume : 9  |  Issue : 4  |  Page : 234-244

Immunohistochemistry in dermatopathology and its relevance in clinical practice

1 Department of Pathology, Government Medical College and Hospital, Chandigarh, India
2 Department of Dermatology, Leprology and Venereology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

Correspondence Address:
Debajyoti Chatterjee
Department of Pathology, Government Medical College and Hospital, Sector 32, Chandigarh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/idoj.IDOJ_8_18

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Immunohistochemistry (IHC) is an important diagnostic tool in histopathology. Dermatopathology is a rapidly developing subspecialty of histopathology. Although IHC is not widely used in routine dermatopathology practice, its application is gradually increasing. IHC is used to differentiate two conditions with similar morphology, to confirm a diagnosis as well as to assess prognosis. It is more commonly used for neoplastic conditions like melanocytic, hematolymphoid, and spindle cell tumors, although uses can be very wide. Although IHC can aid in diagnosis, sometimes interpretation can be difficult as there may be overlapping findings. Thus, IHC should not be interpreted in isolation and should be done in the context of clinical and histological findings. In this review, we have discussed the uses of various immunohistochemical markers in dermatopathology in the light of current literature and their clinical relevance.

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