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Year : 2018  |  Volume : 9  |  Issue : 4  |  Page : 265-267  

Clear cell dermatofibroma on the chest wall: A case report and its diagnostic traps

Department of Pathology, SB University Training and Research Hospital, Antalya, Turkey

Date of Web Publication2-Jul-2018

Correspondence Address:
Tangul Bulut
Department of Pathology, Training SB University Training and Research Hospital, Varlik Mah, Antalya - 07100
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/idoj.IDOJ_289_17

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Dermatofibromas are common lesions of the skin. Although they occur at any part of the body, they are most commonly observed on the lower legs of middle-aged women. The lesion comprises fibroblast-like cells, histiocytes, collagenous tissue, and blood vessels. Many histological variants have been defined based on the ratio of cell components and their location. These variants of dermatofibroma may cause problems during differential diagnosis between benign and malignant mesenchymal lesions of the skin and may lead pathologists to overdiagnose this lesion. Here, we report a case of clear cell dermatofibroma, which is a rare variant of dermatofibroma, together with its diagnostic traps.

Keywords: Clear cell dermatofibroma, clear cell lesions, diagnostic traps, differential diagnosis

How to cite this article:
Bulut T, Celik B. Clear cell dermatofibroma on the chest wall: A case report and its diagnostic traps. Indian Dermatol Online J 2018;9:265-7

How to cite this URL:
Bulut T, Celik B. Clear cell dermatofibroma on the chest wall: A case report and its diagnostic traps. Indian Dermatol Online J [serial online] 2018 [cited 2021 Dec 7];9:265-7. Available from: https://www.idoj.in/text.asp?2018/9/4/265/235711

   Introduction Top

Dermatofibroma (DF) is the most common soft tissue lesion of the skin. It accounts for 3% of the total skin biopsies submitted to each pathological laboratory.[1] Although it can occur at any part of the body, it is most commonly observed on the lower legs of middle-aged women.[2] Despite its benign nature and being considered as an ordinary lesion of the skin by dermatologists at the first glance, pathological diagnosis may be challenging, particularly for rare variants and may lead pathologists to overdiagnose this lesion.[2] The current report presents a case of clear cell dermatofibroma (CCDF), which is a rare variant of DF.

   Case Report Top

A 33-year-old male patient with a nodular mass on the chest wall was admitted to the hospital. He had no significant systemic disease or history of surgery at this site. Abdominal ultrasonography was unremarkable and there were no masses on kidneys. With the clinical diagnosis of hemangioma, excisional biopsy was performed.

Grossly, a yellowish white, well-demarcated but not encapsulated, nodular lesion of the largest diameter 1 cm was observed in the dermis without necrosis or hemorrhage. Microscopic examination revealed a partially-demarcated nodular lesion in the dermis and a Grenz zone between the epidermis and lesion [Figure 1]a. There was an extension toward subcutaneous tissue, but its deep margins were well-circumscribed. At higher magnification, it was observed that the lesion comprised haphazardly distributed vacuolated to optically clear cells. These cells were round-oval shaped with well-defined cell borders and large nuclei showing single prominent, eosinophilic nucleoli [Figure 1]b. Some cells were spindle shaped as well. Cells were surrounded by reticulin fibers and a variable degree of fine-to-sclerotic collagen [Figure 1]b. The lesion was richly vascularized. Occasional lymphocytes were interspersed among the clear cells. Rare mitoses were seen and Ki-67 index was below 1%.
Figure 1: (a) Clear cell lesion situated under the epidermis. Of note, the Grenz zone between the epidermis and lesion (black arrow, H and E, ×20). (b) Optically clear cytoplasm is easily observed in this picture along with haphazardly arranged thick collagen bundles entrapped within the lesion (H and E, ×400)

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A standard three-step streptoavidin–biotin complex method was used for immunohistochemical staining, and all markers were obtained from Novocastra Laboratories (Newcastle, England). The infiltrate was negative for most epithelial and mesenchymal markers, including HMB-45, Melan A, epithelial membrane antigen, pancytokeratin, inhibin, desmin, smooth muscle actin, myoglobin, cytokeratin-8, laminin, calretinin, CD68, CD1a, S-100, renal cell carcinoma (RCC) marker, CD99, CD57, and neurofilament. Vimentin and CD10 were diffusely positive [Figure 2], whereas up to 50% of the lesional cells were positive for FXIIIa [Figure 2]. CD34 only highlighted vascular structures.
Figure 2: Tumor cells are positive with Factor XIIIa and CD10 (both ×100)

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The histopathologic diagnosis rendered was CCDF. No recurrence was seen 2 years after complete excision.

   Discussion Top

The incidences of histological variants of DF are as follows: common variant, 80%; aneurysmal variant, 5.7%; hemosiderotic variant, 5.7%; epithelioid variant, 2.6%; cellular variant, 2.1%; lipidized variant, 2.1%; atrophic variant, 1.0%; and clear cell variant, 0.5%.[2] CCDF, a rare variant of DF, was described by Zelger et al. in 1996.[3] To date, only 14 cases have been reported in the literature, of which four of them were presented as as posters.[4],[5],[6]

When the clear cell changes are seen in a lesion of the skin, a high number of benign or malignant lesions should be considered in the differential diagnosis.[7] Based on histopathologic and immunohistochemical features, the main lesions in the differential diagnosis are summarized in [Table 1]. In the differential diagnosis of epidermal neoplasm, prominent intraepidermal component and/or connection to the epidermis are important indications. In the differential diagnosis of adnexal neoplasms, peripheral palisading of cells and duct-like structures and outer root sheath differentiation are seen; epidermal neoplasms and adnexal neoplasms are positive with epithelial immunohistochemical staining. Myoepithelial lesions and mesenchymal lesions look like CCDF but relevant immunohistochemical staining makes the distinction easy.
Table 1: Differential diagnosis of clear cell changes in skin lesions

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Melanocytic lesions generally have a nested appearance and are positive with melanocytic markers (S-100, HMB45). In addition, clear cell sarcoma is found mainly in deeper structures of younger individuals. Morphological analysis reveals fascicles and islands of round spindled clear cells with vesicular nuclei showing the expression of S-100.

RCC is notorious for metastasizing the unusual sites and, although rare, skin metastasis of RCC occur. CD10 positivity, as observed in our case, may be seen in CCDF and represents the major pitfall in the differential diagnosis of clear cell type RCC.[8] However, the growth pattern of metastasis of RCC is irregular, with necrosis, hemorrhages, marked cellular atypia, and mitoses. Unlike RCC metastasis, FXIIIa positivity is the most important distinctive feature of CCDF.

Prolonged sun exposure, traumatic injury, insect bites, and chronic infection have been suggested as causative agents in the pathogenesis of DF.[4] It was claimed that the documented history of trauma was an evidence of its reactive nature.[9] However, these lesions do not regress spontaneously. Therefore, the neoplastic theory cannot be entirely dismissed. In some cases of DF, clonality has been found, without any consistent karyotypic aberrations.[10]

In summary, although the behavior of DF is generally very indolent, CCDF is confused with other entities showing clear cell changes that have malignant course and pathological diagnosis may be challenging. It is important to avoid misinterpretation of this lesion, in particular metastasis of RCC or clear cell sarcoma to the skin.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

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Conflicts of interest

There are no conflicts of interest.

   References Top

Rahbari H, Mehregan AH. Adnexal displacement and regression in association with histiocytoma (dermatofibroma). J Cutan Pathol 1985;12:94-102.  Back to cited text no. 1
Alves JV, Matos DM, Barreiros HF, Bártolo EA. Variants of dermatofibroma - a histopathological study. An Bras Dermatol 2014;89:472-7.  Back to cited text no. 2
Zelger B, Steiner H, Kutzner H. Clear cell dermatofibroma. Case report of an unusual fibrohistiocytic lesion. Am J Surg Pathol 1996;20:483-91.  Back to cited text no. 3
Wambacher-Gasser B, Zelger B, Zelger BG, Steiner H. Clear cell dermatofibroma. Histopathology 1997;30:64-9.  Back to cited text no. 4
Paties C, Vassallo G, Taccagni GL. Clear Cell Dermatofibroma. Am J Surg Pathol 1997;21:250-2.  Back to cited text no. 5
Riopel C, Musette P, Bodenant C, Belanyi P, Joly P, Courville P. Clear cell dermatofibroma: A case report with cytogenetic study. Ann Pathol 2004;24:440-5; quiz 393.  Back to cited text no. 6
Smith EH, Andea AA. Cutaneous clear cell neoplasms: A systematic review. Diagn Histopathol 2016;22:134-41.  Back to cited text no. 7
Mechtersheimer G, Möller P. Expression of the common acute lymphoblastic leukemia antigen (CD10) in mesenchymal tumors. Am J Pathol 1989:134:961-5.  Back to cited text no. 8
Hoffman S, Martinez MG Jr. Fibrous histiocytomas of the oral mucosa. Oral Surg Oral Med Oral Pathol 1981;52:277-83.  Back to cited text no. 9
Calonje E. Is cutaneous benign fibrous histiocytoma (dermatofibroma) a reactive inflammatory process or a neoplasm? Histopathology 2000;37:278-80.  Back to cited text no. 10


  [Figure 1], [Figure 2]

  [Table 1]

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