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Year : 2020  |  Volume : 11  |  Issue : 5  |  Page : 693-700

Colchicine in dermatology: Rediscovering an old drug with novel uses

Department of Dermatology, STD and Leprosy, ABVIMS and Dr. Ram Manohar Lohia Hospital, New Delhi, India

Correspondence Address:
Kabir Sardana
Department of Dermatology, ABVIMS and Dr. RML Hospital, New Delhi
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/idoj.IDOJ_475_20

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Colchicine is an anti-inflammatory agent which has been used for decades in the treatment of gout. The drug has a number of dermatological indications like Psoriasis, Sweet's syndrome, aphthosis, Behcet's disease, erythema nodosum, leukocytoclastic vasculitis and is consistently effective in neutrophilic disorders. Thought it is an affordable with minimal side effects, It has remained underutilized. However, it has novel uses and is being considered in COVID-19 due to its action on IL-1β and IL-6. This article presents a concise and up-to-date review focusing on its mechanisms of action and indications.

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