• Users Online: 729
  • Print this page
  • Email this page

  Table of Contents  
Year : 2020  |  Volume : 11  |  Issue : 6  |  Page : 1036-1037  

Giant angina bullosa haemorrhagica

1 Department of Dermatology, Lady Hardinge Medical College and Associated Hospitals, Shaheed Bhagat Singh Marg, New Delhi, India
2 Department of Medicine, Lady Hardinge Medical College and Associated Hospitals, Shaheed Bhagat Singh Marg, New Delhi, India

Date of Submission26-Aug-2019
Date of Decision23-Oct-2019
Date of Acceptance26-Nov-2019
Date of Web Publication08-Nov-2020

Correspondence Address:
Anuja Yadav
Department of Dermatology and STD, Lady Hardinge Medical College and Associated Hospitals, Shaheed Bhagat Singh Marg, New Delhi - 110 001
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/idoj.IDOJ_431_19

Rights and Permissions

How to cite this article:
Yadav P, Yadav A, Chander R, Sharma AK. Giant angina bullosa haemorrhagica. Indian Dermatol Online J 2020;11:1036-7

How to cite this URL:
Yadav P, Yadav A, Chander R, Sharma AK. Giant angina bullosa haemorrhagica. Indian Dermatol Online J [serial online] 2020 [cited 2021 Jun 25];11:1036-7. Available from: https://www.idoj.in/text.asp?2020/11/6/1036/300312

A 75-year-old lady, developed an asymptomatic, blood filled blister over the right buccal mucosa overnight after eating rice-chapati at night. Examination of oral mucosa revealed a single oval, tense, blood filled bullae of size around 4 cm on right buccal mucosa [Figure 1] and [Figure 2]. There was no history of inhaled steroids, infections, autoimmune diseases, diabetes, dental procedures and anesthetic procedures. She was a non-smoker and non-alcoholic. She had history of chest discomfort 3 years back which was diagnosed as unstable angina. Since then, she was receiving tablets clopidogrel, aspirin, atorvastatin; along with sublingual isosorbide dinitrate on an SOS basis. Hematological and biochemical investigations and coagulation profile were normal. The bulla ruptured in the next evening leaving behind erosion which was associated with pain while eating. It healed over the next 2 weeks without any scarring with symptomatic improvement. Angina bullosa haemorrhagica (ABH) is an interesting entity which presents as sudden onset of painless, blood-filled blisters of the oral cavity that rapidly expand and rupture spontaneously within 24-48 hours. ABH is often asymptomatic. However, sometimes, pain or a sensation of choking can be reported.[1] Angina term comes from the choking sensation. The exact cause of ABH has not been yet elucidated but the various etiologies mentioned in the literature are related to the minor trauma of hot foods, restorative dentistry, periodontal therapy, dental injections of anesthetics, chlorhexidine gluconate mouth rinse and steroid inhalers.[2] Diabetes mellitus and arterial hypertension may be predisposing factors.[3] Food ingestion has been implicated to be the most common cause accounting for 50-100% of cases.[4] The differential diagnoses of ABH include mucous membrane pemphigoid, epidermolysis bullosa acquisita, linear IgA dermatosis, erythema multiforme, oral amyloidosis, pemphigus, dermatitis herpetiformis, and bullous lichen planus. Our case was interesting because of a large lesion with normal coagulation profile.
Figure 1: Large blood filled bulla over the right buccal mucosa

Click here to view
Figure 2: Bulla ruptured the next evening revealing blood and leaving behind an erosion

Click here to view

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.

   References Top

Cinar SL, Kartal D, Canöz Ö, Borlu M, Ferahbas A. Case report: A rare cause of oral bullae: Angina Bullosa Hemorrhagica F1000Res 2017;6:1974.  Back to cited text no. 1
Yamamoto K, Fujimoto M, Inoue M, Maeda M, Yamakawa N, Kirita T. Angina bullosa hemorrhagica of the soft palate: Report of 11 cases and literature review. J Oral Maxillofac Surg 2006;64:1433-6.  Back to cited text no. 2
Paci K, Varman KM, Sayed CJ. Hemorrhagic bullae of the oral mucosa. JAAD Case Rep 2016;2:433-35.  Back to cited text no. 3
Horie N, Kawano R, Inaba J, Numa T, Kato T, Nasu D, et al. Angina bullosa hemorrhagica of the soft palate: A clinical study of 16 cases. J Oral Sci 2008;50:33-6.  Back to cited text no. 4


  [Figure 1], [Figure 2]


    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

  In this article
    Article Figures

 Article Access Statistics
    PDF Downloaded38    
    Comments [Add]    

Recommend this journal