• Users Online: 709
  • Print this page
  • Email this page


 
  Table of Contents  
THROUGH THE LENS
Year : 2020  |  Volume : 11  |  Issue : 6  |  Page : 1038-1039  

Idiopathic acquired true leukonychia totalis and partialis: Two case reports


Department of Dermatology, Venereology and Leprosy, Dr. Ram Manohar Lohia and Post Graduate Institute of Medical Education and Research, New Delhi, India

Date of Submission27-Sep-2019
Date of Decision19-Nov-2019
Date of Acceptance15-Dec-2019
Date of Web Publication19-Sep-2020

Correspondence Address:
Konchok Dorjay
Department of Dermatology, Venereology and Leprosy, Dr. Ram Manohar Lohia and Post Graduate Institute of Medical Education and Research, New Delhi - 110 001
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/idoj.IDOJ_490_19

Rights and Permissions

How to cite this article:
Mathachan SR, Dorjay K, Sinha S. Idiopathic acquired true leukonychia totalis and partialis: Two case reports. Indian Dermatol Online J 2020;11:1038-9

How to cite this URL:
Mathachan SR, Dorjay K, Sinha S. Idiopathic acquired true leukonychia totalis and partialis: Two case reports. Indian Dermatol Online J [serial online] 2020 [cited 2020 Nov 25];11:1038-9. Available from: https://www.idoj.in/text.asp?2020/11/6/1038/295465



A 20-year-old male presented with a history of whitening of nails which was insidious in onset progressed to symmetrical total whitening of all fingernails and partial whitening of all toenails within 1 year [Figure 1]. Examination revealed opaque porcelain-white discoloration of all fingernails with partial involvement of all toenails. On blanching, white discoloration remained the same. A second similar case was seen in an 18-year-old male with a history of progressive whitening of fingernails and toenails for the past 3 years [Figure 2]. On examination, total porcelain white discoloration was seen in all fingernails and toenails except the thumb and great toenails where partial leukonychia was present. There was no history of preceding trauma, illness, drug intake, or exposure to chemicals and no similar changes were seen in the family members of both cases. The rest of the mucocutaneous and systemic examination was unremarkable. No skin lesions suggestive of psoriasis or lichen planus were seen. Routine hematological and biochemical blood investigations were normal. Nail clipping Periodic acid Schiff stain (PAS) and 20% KOH test showed no fungal elements and the culture revealed no fungal growth. On the basis of history and clinical examination, a diagnosis of idiopathic acquired true total and partial leukonychia was made. Both patients were counseled regarding the benign nature of the condition, and there were no changes noticed in leukonychia during the follow-up period.
Figure 1: Case 1 with symmetrical total whitening of all fingernails and partial whitening of all toenails

Click here to view
Figure 2: Case 2 with total whitening of fingernails and toenails

Click here to view


Leukonychia or white nails can be broadly classified based on morphology into leukonychia punctate, leukonychia striata, leukonychia partialis, and leukonychia totalis. True leukonychia characterized by the involvement of the nail plate can be either hereditary or acquired.[1] True leukonychia occurs as a result of abnormal keratinization of the distal matrix resulting in persistent parakeratosis and retained keratohyalin granules in the nail plate. This causes reflection of light by the nail plates and thus prevents the visualization of the underlying nail bed.[2] True leukonychia occurs due to nail plate abnormality and must be distinguished from the more common apparent leukonychia where nail bed disorders are the underlying cause.[3],[4]

Hereditary true leukonychia may be inherited in an autosomal-dominant or autosomal recessive pattern—either as an isolated finding or as a part of a syndrome. Acquired true leukonychia may be either idiopathic or induced by trauma, drug intake, exposure to chemicals, systemic or local infections, and inflammatory diseases.[3],[5] In our patients, none of the above mentioned associations could be elucidated; hence, a diagnosis of acquired idiopathic true leukonychia was made in both.

Our study will add two more cases of idiopathic acquired true leukonychia totalis and partialis in addition to the 12 cases that have been found in the literature so far. All reported cases including our two cases were young men and boys with age at the time of presentation ranging from 12 to 32 years. Both our cases had involvement in all the 20 nails; only two cases involving all 20 nails have been reported so far.[2] We report these cases in view of the rarity of this condition and the involvement of all the nails.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to b'e reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
   References Top

1.
Claudel CD, Zic JA, Boyd AS. Idiopathic leukonychia totalis and partialis in a 12-year-old patient. J Am Acad Dermatol 2001;44:379-80.  Back to cited text no. 1
    
2.
Canavan T, Tosti A, Mallory H, McKay K, Cantrell W, Elewski B. An idiopathic leukonychia totalis and leukonychia partialis case report and review of the literature. Skin Appendage Disord 2015;1:38-42.  Back to cited text no. 2
    
3.
Bakry OA, Attia AM, Shehata WA. Idiopathic acquired true leukonychia totalis. Pediatr Dermatol 2014;31:404.  Back to cited text no. 3
    
4.
Stewart L, Young E, Lim HW. Idiopathic leukonychia totalis and partialis. J Am Acad Dermatol 1985;13:157-8.  Back to cited text no. 4
    
5.
Arsiwala SZ. Idiopathic acquired persistent true partial to total leukonychia. Indian J Dermatol 2012;78:107.  Back to cited text no. 5
[PUBMED]  [Full text]  


    Figures

  [Figure 1], [Figure 2], [Figure 1], [Figure 2]



 

Top
 
 
  Search
 
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this article
    References
    Article Figures

 Article Access Statistics
    Viewed223    
    Printed2    
    Emailed0    
    PDF Downloaded3    
    Comments [Add]    

Recommend this journal