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CONCISE COMMUNICATION
Year : 2021  |  Volume : 12  |  Issue : 5  |  Page : 755-757  

Subacute cutaneous lupus erythematosus: Diagnosis and follow up by dermoscopy


1 Department of Dermatology, and Venereology, AIIMS, Bhubaneswar, Odisha, India
2 Department of Pathology, AIIMS, Bhubaneswar, Odisha, India

Date of Submission06-Dec-2020
Date of Decision22-Mar-2021
Date of Acceptance12-May-2021
Date of Web Publication02-Aug-2021

Correspondence Address:
Biswanath Behera
Department of Dermatology, and Venereology, AIIMS, Bhubaneswar, Odisha - 751 019
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/idoj.IDOJ_906_20

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How to cite this article:
Behera B, Nayak AK, Dash S, Sethy M. Subacute cutaneous lupus erythematosus: Diagnosis and follow up by dermoscopy. Indian Dermatol Online J 2021;12:755-7

How to cite this URL:
Behera B, Nayak AK, Dash S, Sethy M. Subacute cutaneous lupus erythematosus: Diagnosis and follow up by dermoscopy. Indian Dermatol Online J [serial online] 2021 [cited 2021 Sep 28];12:755-7. Available from: https://www.idoj.in/text.asp?2021/12/5/755/322698



A 60-year-old male of skin phototype V presented with a one-month history of multiple scaly skin lesions on the anterior chest, back, and face. It was associated with a history of photosensitivity and on-and-off joint pain. He denied any systemic complaints. Cutaneous examination showed multiple well-defined erythematous to hypopigmented scaly papules and plaques [Figure 1]a on the sites, as mentioned earlier. Other mucocutaneous, general, and systemic examinations were within normal limits. Differential diagnosis of subacute cutaneous lupus erythematosus (SCLE) and psoriasis was considered. Dermoscopy (Dermlite, DL4, 10x magnification) under polarized mode showed patchy to diffuse white scales, white structureless area, white shiny structures (white shiny structureless area, clods, and lines), focal multicolored (not rainbow) pattern, brown to blue-gray peppering, follicular plugging, and linear, linear curved (comma), and focal dotted vessels [Figure 1]b, [Figure 1]c, [Figure 1]d, [Figure 1]e, [Figure 1]f, [Figure 1]g. Laboratory examination showed a positive antinuclear (3+), anti-Ro antibodies, and deranged renal parameters (urea-48 mg/dl, creatinine-3.1 mg/dl). Other investigations were within normal limits. Histology showed hyperkeratotic atrophic epidermis, basal vacuolar degeneration, cytoid bodies, dermal melanophages, melanin incontinence, and upper dermal dilated blood vessels [Figure 2]a, [Figure 2]b. Direct immunofluorescence showed linear deposition of IgG, IgA, IgM, and C3 along the basement membrane zone. The diagnosis of SCLE was made. The patient was started on oral prednisolone 1 mg/kg/day, hydroxychloroquine 300 mg once daily, along with photoprotective measures. After 2 months of treatment, a significant reduction in scaling and thickness of the plaques along with post-inflammatory hypo to depigmentation was noticed without any evidence of scarring [Figure 3]a. Repeat dermoscopic examination showed the disappearance of white shiny structures, scaling, and follicular plugging along with the reduction of vascular structures [Figure 3]b, [Figure 3]c, [Figure 3]d.
Figure 1: (a) Multiple well-defined erythematous to hypopigmented scaly plaques. Dermoscopy (Dermlite, DL4, 10x magnification) under polarized mode showing (b) white structureless area (red arrow) and white shiny structures (blue arrow). (c) Focal multi-coloured pattern (blue arrow), blue-gray peppering, follicular plugging (black arrow), and dotted and linear curved vessel (red arrow). (d) Follicular plugging (blue arrow) and dotted vessels. (e) White structureless area, white shiny structures, and focal dotted vessels (red arrow). (f) White homogenous area with linear vessels (arrows). (g) White homogenous area, white shiny structures with linear and comma vessels (arrows)

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Figure 2: (a) Histology showing hyperkeratotic atrophic epidermis and interface dermatitis (H & E, X100). (b) Cytoid bodies, dermal melanophages, melanin incontinence, and upper dermal dilated blood vessels (H & E, X400)

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Figure 3: (a) Post-therapy resolution of scaling and development of post-inflammatory depigmentation. Dermoscopy (Dermlite, DL4, 10x magnification) under polarized mode showing (b-d) disappearance of white shiny structures, follicular plugging (blue arrows) and the persistence of few blood vessels (red arrows).

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The SCLE is characterized by the presence of cutaneous lesions of papulosquamous or annular polycyclic morphology. It usually has a good prognosis with rare systemic involvement. The lesions typically heal without scarring and with vitiligo-like hypo-depigmentation. Except for the apparent disappearance of scaling, there is no objective way to assess cutaneous lesions' improvement. The associated hypo to depigmentation even makes the task challenging to appreciate the clinical improvement. Besides, in the absence of systemic features, at times, it can be challenging to differentiate SCLE from clinical mimics like psoriasis, pityriasis rosea, nummular eczema, erythema annulare centrifugum, dermatomyositis, and, most importantly, from disseminated discoid lupus erythematosus, especially in the early stage when the scarring is absent or minimal.

Dermoscopy is increasingly used for the diagnosis of various inflammatory dermatoses. The dermoscopic data of SCLE is limited. Dermoscopic features described for SCLE are diffuse or peripherally arranged whitish scales and a mixed vascular pattern comprising linear, linear irregular, branching, and sparsely distributed dotted vessels over a pinkish–reddish background.[1] In the index case, in addition to the white scales and mixed vascular pattern, we observed new dermoscopic features such as white shiny structures, follicular plugging, and focal multicolored pattern. The multicolored pattern included white, pink, purple, and reddish-orange color. The shiny white structures possibly correlate with the compact hyperkeratosis, and the multicolored pattern to the increased vascularity.[2]

The common mimicker of SCLE, psoriasis, is characterized by the presence of regularly distributed dotted vessels over a pinkish-white background.[3]

The presence of linear, linear branching, and linear irregular vessels is due to the horizontally placed dilated blood vessels below the atrophic epidermis. In contrast, the dotted vessels observed in psoriasis are due to the dilated and tortuous vessels placed perpendicular to the epidermis in the papillary dermis between the elongated rete ridges. Pityriasis rosea typically shows a collarette of scales, central yellow, peripheral or diffuse reddish background, and patchy peripheral or scattered dotted vessels.[4],[5] The eczematous conditions commonly have patchy dotted vessels and yellow crust.[6] In addition, white shiny areas, and follicular plugging have not been described in the above conditions. In the index case, the disappearance of the white shiny areas were associated with the lesions' clinical improvement, a feature that can be used for therapeutic response assessment. In addition, there was a disappearance of scaling, follicular plugging, and blood vessels.

In conclusion, we report new dermoscopic features in a case of SCLE, namely, white shiny structures, focal multicolored pattern, and follicular dilatation and plugging. The disappearance of the above structure correlated with clinical improvement, which may indicate the therapeutic response. Larger studies are needed to verify our findings.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
   References Top

1.
Errichetti E, Piccirillo A, Viola L, Stinco G. Dermoscopy of subacute cutaneous lupus erythematosus. Int J Dermatol 2016;55:e605-7.  Back to cited text no. 1
    
2.
Dash S, Behera B, Palit A, Sethy M, Nayak AK, Ayyanar P. An unusual dermoscopic presentation of eruptive lichen planus dominated by rosettes and blink sign. Australas J Dermatol 2021;62:72-5.  Back to cited text no. 2
    
3.
Lallas A, Argenziano G, Apalla Z, Gourhant JY, Zaballos P, Di Lernia V, et al. Dermoscopic patterns of common facial inflammatory skin diseases. J Eur Acad Dermatol Venereol 2014;28:609-14.  Back to cited text no. 3
    
4.
Chuh AA. Collarette scaling in pityriasis rosea demonstrated by digital epiluminescence dermatoscopy. Australas J Dermatol 2001;42:288-90.  Back to cited text no. 4
    
5.
Elmas ÖF, Kilitçi A, Acar EM. Dermoscopic profile of pityriasis rosea. Dermatol Sin 2019;37:199-204.  Back to cited text no. 5
  [Full text]  
6.
Errichetti E, Stinco G. Dermoscopy in general dermatology: A practical overview. Dermatol Ther (Heidelb) 2016;6:471-507.  Back to cited text no. 6
    


    Figures

  [Figure 1], [Figure 2], [Figure 3]



 

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