Indian Dermatology Online Journal

LETTER TO THE EDITOR
Year
: 2018  |  Volume : 9  |  Issue : 4  |  Page : 281-

Comment on “Mean platelet volume: A reliable marker of inflammation in recurrent aphthous stomatitis and Behçet's disease?”


Esin Avsar 
 Department of Internal Medicine, Akdeniz University Faculty of Medicine, Antalya, Turkey

Correspondence Address:
Esin Avsar
Department of Internal Medicine, Akdeniz University Faculty of Medicine, Antalya - 07070
Turkey




How to cite this article:
Avsar E. Comment on “Mean platelet volume: A reliable marker of inflammation in recurrent aphthous stomatitis and Behçet's disease?”.Indian Dermatol Online J 2018;9:281-281


How to cite this URL:
Avsar E. Comment on “Mean platelet volume: A reliable marker of inflammation in recurrent aphthous stomatitis and Behçet's disease?”. Indian Dermatol Online J [serial online] 2018 [cited 2021 Apr 14 ];9:281-281
Available from: https://www.idoj.in/text.asp?2018/9/4/281/235719


Full Text



Sir,

We read with interest the article by Şenel et al., who compared mean platelet volume (MPV) in recurrent aphthous stomatitis and Behçet's disease. They conclude that MPV levels could not be used as an indicator or a diagnostic marker for the patients with Behçet's disease and recurrent aphthous stomatitis.[1] However, there are major problems in this study:

This study has no exclusion criteria. However, there are many diseases and medications affecting MPV levels [2]In this study, MPV measurement technique is not written. Preanalytical variables, such as the anticoagulant used, and the time between blood collection and measurement are known to significantly affect MPV measurements. Although ethylenediaminetetraacetic acid (EDTA) is traditionally used and recommended for samples destined for blood counting, it is well known that platelets collected into EDTA anticoagulants undergo time-dependent platelet swelling and activation.[3],[4] What were made in order the platelet swelling induced by EDTA?What are the date ranges of this study? Because recent studies have shown seasonal changes in MPV levels.[5]There are three groups in this study. For this reason, analysis of variance test (including post hoc) should be applied in statistical analysisThis study is retrospective. One of the main limitation of this study is that analysis was based on a simple baseline determination that may not reflect in patient's status over long period (should be written “Discussion-limitations” section).

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

References

1Şenel E, Acar B, Demir E. Mean platelet volume: A reliable marker of inflammation in recurrent aphthous stomatitis and Behçet disease? Indian Dermatol Online J 2017;8:468-70.
2Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Mean platelet volume: A link between thrombosis and inflammation? Curr Pharm Des 2011;17:47-58.
3Jackson SR, Carter JM. Platelet volume: Laboratory measurement and clinical application. Blood Rev 1993;7:104-13.
4Harrison P, Goodall AH. Studies on mean platelet volume (MPV) – New Editorial Policy. Platelets 2016;27:605-6.
5Crawford VL, McNerlan SE, Stout RW. Seasonal changes in platelets, fibrinogen and factor VII in elderly people. Age Ageing 2003;32:661-5.