Indian Dermatology Online Journal

: 2021  |  Volume : 12  |  Issue : 1  |  Page : 14--23

Dermatoscopy of infections and infestations

Manas Chatterjee1, Shekhar Neema2,  
1 Department of Dermatology, CH EC, Kolkata, West Bengal, India
2 Department of Dermatology, AFMC, Pune, Maharashtra, India

Correspondence Address:
Shekhar Neema
Department of Dermatology, AFMC, Pune - 40, Maharashtra


Dermoscopy is a non-invasive tool for the diagnosis of skin diseases. Entomodermoscopy is a branch of dermoscopy that deals with infections and infestations. The use of dermoscopy for diagnosis of infections and infestations is rapidly increasing as it can provide useful clues related to diagnosis and effectiveness of treatment. It serves as a useful adjunct to microbiological and histopathological examination. In some cases, like scabies dermoscopy can even clinch the diagnosis.

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Chatterjee M, Neema S. Dermatoscopy of infections and infestations.Indian Dermatol Online J 2021;12:14-23

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Chatterjee M, Neema S. Dermatoscopy of infections and infestations. Indian Dermatol Online J [serial online] 2021 [cited 2021 Apr 17 ];12:14-23
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Dermoscopy is a non-invasive tool for the diagnosis of skin diseases. It was primarily used for diagnosis of skin tumors; however, of late its use has become widespread in general dermatology. Dermoscopy as a discipline is subclassified depending on the diseases in which it is used: entomodermoscopy refers to dermoscopy of infections and infestations, inflammoscopy to inflammatory disorders and pigmentaroscopy to disorders of pigmentation. It can also be classified depending on regions as onychoscopy, trichoscopy, and mucoscopy as dermoscopy of diseases involving nails, hairs, and mucous membrane, respectively.

The dermoscopic examination in infections and infestations requires special precautions as there is a risk of transmission of infection between patients and between patient and physician. The advances in dermoscope such as non-contact dermoscope and use of a barrier such as ice cap and the like, have reduced this risk and made entomodermoscopy safer. The interface fluid when used should be alcohol-based disinfectant to reduce infection transmission. In this article, we aim to provide an overview on use of dermoscopy in infections and infestations.



Scabies is an intensely pruritic skin disease caused by infestation with mite Sarcoptes scabiei var hominis. It is an obligate human parasite with female mite measuring approx. 0.3 X 0.5 mm and males being even smaller. The average number of mites present in a symptomatic individual is approximately 10–12. Skin scraping and demonstration of mite, ova or scybala (feces) are considered diagnostic. Dermoscopy can be used for rapid diagnosis of scabies and is 91% sensitive and 86% specific. It has higher sensitivity and lower specificity for diagnosis as compared to skin scraping.[1] Triangle or delta-wing jet with contrails is the classical dermoscopic feature of scabies where triangle represent anterior part of mite and contrail represents the burrow. Another named sign in diagnosis of scabies is Hang glider sign in which brown triangle of the hang-glider corresponding to anterior part of mite [Figure 1].[2] The abdomen of the mite and eggs are translucent and are not visible on dermoscopy. Application of ink can improve visualization of these structures. It is especially useful in nodular, crusted, and infantile scabies where the diagnosis is difficult clinically. In crusted scabies, noodle sign is seen which is nothing but presence of numerous burrows.[3]{Figure 1}


Lice infestations are quite common worldwide. The three lice that infest humans are Head lice (Pediculus humanis capitis), body lice (Pediculus humanis humanis) and pubic or crab louse (Pthirus pubis). Head lice infestations are quite common and affect school-going children. Pubic louse is transmitted as a sexually transmitted infection and body lice affect homeless and destitute. Diagnosis of head lice is confirmed by visualization of lice or by the presence of nits along with scalp pruritus and cervical lymphadenopathy.[4] Dermoscopy can be used for rapid diagnosis of pediculosis capitis and can be used for screening. It can also be used to monitor treatment as presence of only empty nits suggest cure.[5] Dermoscopic features are:

Visualization of live crawling headlouse is diagnostic [Figure 2]Nits containing vital nymph (live nits) are brown colored and ovoid in shape [Figure 3]Empty nits are translucent and have fissured endsPseudo-nits, which can be scales resulting from seborrheic dermatitis, hair spray, or other external agents should be differentiated from nits. While nits (live or empty) are attached to hair shaft, the pseudo-nits appear as amorphous material and are not attached to hair-shaft.{Figure 2}{Figure 3}

Pubic louse or Phthirus pubis is approximately 1.5–2 mm long, has round body and stout posterior pair of legs and have large claws, hence the name Crab louse. Patients present with pubic pruritus and blue gray macules (maculae ceruleae), Dermoscopy can be used for rapid diagnosis as it is difficult to visualize the louse with naked eye. It can also be used to locate the louse in unusual places such as eyelashes. Nits are attached to base of hair; live nits are brown in color and empty nits are translucent [Figure 4] and [Figure 5].[6] Use of video-dermoscopy is advisable as use of hand-held dermoscope in genital area is difficult and embarrassing.{Figure 4}{Figure 5}


Demodex folliculorum is a commensal mite seen in pilosebaceous unit. When the density of mite increases, it may result in demodicosis which can present with rosacea or perioral dermatitis like clinical features. Diagnosis is confirmed by standardized skin surface biopsy with demodex count more than 5/cm2. Dermoscopy can help in rapid diagnosis of demodicosis.[7] Dermoscopic features of demodicosis are

Visualization of demodex tails as gelatinous, whitish creamy threads measuring 1–3 mm is the most specific feature [Figure 6]Follicular gray dots and interfollicular scales can also be seenTelangiectasias may be seen in cases of secondary demodicosis due to steroid abuse or in case of rosaceaDemodex mite can cause pruritus and can result in facial frictional melanoses.{Figure 6}

Cutaneous larva migrans

Cutaneous larva migrans (CLM) is a parasitic disease caused by animal hookworm larvae, most commonly Ancylostoma braziliense. The hookworm larvae penetrate through intact skin and is characterized by intensely pruritic, serpiginous, creeping eruption with most common presentation over feet and buttocks. The diagnosis is based on classical clinical features. Dermoscopic features of CLM are not diagnostic but dermoscopic features may be used as an adjunct to the diagnosis. It reveals dotted vessels in empty burrow and translucent brownish or yellow structureless area representing the body of the larva [Figure 7].[8]{Figure 7}

Tick bite

Ticks are vectors of many bacterial and protozoal diseases including Lyme disease. Rocky mountain spotted fever, Indian tick typhus, ehrlichiosis, tick paralysis, and many other diseases. Diseases transmission requires 24–48 hours of tick attachment. It is important to identify and remove the tick for diagnostic and therapeutic purposes. Dermoscopy can aid in tick detection, species identification and locating retained hypostome (mouth parts) after tick removal. Dermoscopy shows tick as round lesion with surrounding erythema. Retained hypostome after removal of tick is seen as brown to black-grey areas [Figure 8].[9]{Figure 8}


Myiasis is defined as infestation of live humans by larvae of order Diptera. Cutaneous myiasis can be classified as furuncular, wound, and migratory myiasis. Dermatobia hominis is the most common cause of furuncular and wound myiasis. Furuncular myiasis is endemic in African region and patients generally have travel history. Wound myiasis occurs in neglected patients in low socio-economic strata. Diagnosis is usually made based on clinical features in appropriate setting. On submerging the limb under water or oil, bubbles can be seen if the larva is alive.[10] Dermoscopy can be used in diagnosis of myiasis. Larva feeds in subdermal area for 5–10 weeks and breathe through a pore. Dermoscopy shows creamy-white body and yellow structureless areas representing breathing spiracles in center which is surrounded by black dots representing small spines in a circular row.[11] Wound myiasis is usually diagnosed by demonstration of live larvae in the wound. Dermoscopy can help in confirmation of diagnosis in which various body parts of larvae can be identified. Larvae appears as yellowish white structures with brown dots, respiratory spiracle, and tracheal tubes. Dermoscopy may also help in species identification.[12]

 Viral Infections

Human papilloma virus infection

Human papilloma virus (HPV) infection is a common viral infection and present clinically as verrucae (warts) on skin or mucous membranes. HPV infection is transmitted by direct/indirect contact. It is one of the most common sexually transmitted infections. Various types of HPV are associated with different types of warts. Oncogenic strains or high-risk types (HPV 6,11,16,18,31,35) of HPV are associated with cervical, penile, anal, and oral cancer.[13]

Common warts

These are caused by HPV 1, 2, 4, 27, 57, and 63 and present as elevated rounded papules with rough, verrucous surface, commonly over hands. Dermoscopy shows well-defined lesions with irregular whitish structures surrounding hemorrhagic red to black dots and globules. Linear hairpin and coiled vessels may be seen. Hyperkeratotic warts show predominant whitish structures while exophytic or filiform warts appear as finger like projections containing elongated and dilated vessels [Figure 9].[14]{Figure 9}

Flat warts

Also known as verrucae plana, they are caused by HPV type 3, 10, 28, and 41, characterized by flat-topped, skin colored papules and most commonly seen on face and dorsum of hand. Dermoscopy shows presence of regular red dots on white or light brown background. Absence of dermatoglyphics is another indicator on dermoscopy [Figure 10].[14]{Figure 10}

Plantar warts

Palmoplantar warts are caused by HPV 1, 2, 27, and 57 and appear as skin colored papules or plaques. They can progress to deep endophytic, sharply defined lesions known as myrmecia warts, usually occurring on weight bearing areas of metatarsal heads and heel. Dermoscopy shows prominent red to black dots and interrupted dermatoglyphics, especially after gentle paring. In contrast, calluses show presence of dermatoglyphics [Figure 11].[14]{Figure 11}

Genital warts

They are also known as condylomata acuminata and spread sexually. These are most commonly caused by HPV 6 and 11. Some HPV types like 16, 18, 31, 35 causing genital warts have oncogenic potential. Genital warts can present as exophytic or sessile soft papules involving anogenital skin. They generally involve foreskin, coronal sulcus, and glans in men and introitus, vagina, labia, and perineum in women. Dermoscopy helps in ruling out other differential diagnoses like molluscum contagiosum, pearly penile papules, condylomata lata, and Fordyce's spots. Dermoscopy depends on morphology of the genital warts. Sessile lesion shows dotted vessels and whitish network [Figure 12]. Pedunculated lesion shows whitish finger like projections and elongated dilated vessels in the finger-like projections [Figure 13].[15]{Figure 12}{Figure 13}

Molluscum contagiosum (MC)

It is an infection caused by molluscipox virus. It is a common infection in children while in adult, genital molluscum is a sexually transmitted infection. It presents as asymptomatic, single, or multiple, skin colored, umbilicated papules. The diagnosis of MC is clinical and confirmation is by demonstration of Henderson -Patterson bodies in Tzanck smear and histopathology rarely. The differential diagnoses of MC are common warts, keratoacanthoma, syringoma, and sebaceous hyperplasia. Dermoscopy of MC shows multiple yellow-white clods representing molluscum bodies and peripheral crown vessels [Figure 14].[16]{Figure 14}

 Fungal Infections

Superficial fungal infections are one of the most common infections presenting to dermatology outpatient department for treatment and the diagnosis of these infections are made clinically and microbiological confirmation is done using 10% potassium hydroxide (KOH) mount and culture.

Tinea corporis

It is superficial infection of non-glabrous skin caused by dermatophytes. It includes infection of skin of trunk and limbs and excludes special sites like scalp, palms, and soles, groin, and feet. Fungi which cause infection of stratum corneum, hair and nails are dermatophytes and are classified in three genera; Microsporum, Trichophyton, and Epidermophyton. The predominant species causing infection varies according to region. Tine corporis presents with single or multiple annular, erythematous plaques with peripheral scaling. Dermoscopy helps in diagnosis, especially in patients with steroid modified tinea; it can also be used as a criterion to start systemic antifungal therapy based on involvement of vellus hair. Dermoscopy shows peripheral white scales with outer border being sharply demarcated [Figure 15]. Double edged scales may be seen in skin folds. Dotted vessels may be seen in the periphery of the lesion. Vellus hair involvement is seen as brown spots surrounded by white halo and loss of vellus hair. Involvement of vellus hair is an indication to start systemic treatment even in a patient with single lesion, as it can serve as reservoir of infection [Figure 16]. Double border is seen in steroid modified tinea [Figure 17].[17] Tinea mannum shows white scales localized to furrows [Figure 18].{Figure 15}{Figure 16}{Figure 17}{Figure 18}

Pityriasis versicolor

Tinea versicolor is a superficial fungal infection caused by Malassezia species. It presents as hypo, hyperpigmented, or erythematous scaly macules on trunk and chest. Diagnosis is made on clinical grounds and microscopy showing “spaghetti and meatball” appearance. Dermoscopy shows fine white scaling localized to furrows and around the follicles [Figure 19] and [Figure 20]. Brownish reticular pigment network in hyperpigmented lesions and reduced pigmentary network in hypopigmented lesions can be seen. Kaur et al., has described “Contrast halo sign” in 66.67% cases in their study where a ring of contrast color to that of primary lesion surrounds its periphery.[18]{Figure 19}{Figure 20}

Cutaneous candidiasis

Cutaneous candidiasis is caused by candida species. It is common in extremes of age and is associated with immunosuppression like diabetes mellitus and HIV infection. It most commonly presents with erythematous and macerated plaques involving intertriginous areas of the body. Satellite pustules are seen. KOH mount shows pseudohyphae. Inverse psoriasis and eczema can be a differential diagnosis and can make diagnosis difficult. Dermoscopy shows polycyclic erosions and peripheral yellow scales. These yellow scales appear like “cottage cheese”.. Dilated vessels may be seen in the center of lesion and satellite pustules in periphery [Figure 21].[19]{Figure 21}

Tinea nigra

It is superficial infection of skin of palms and soles caused by dematiaceous fungi Hortaea Werneckii. It presents as gradually progressive black or brown asymptomatic macules on palms and soles. It can be confused with acral melanoma. Dermoscopy may help in diagnosis and prevent unnecessary biopsy. Dermoscopy shows superficial, wispy, light brown strands in reticular pattern which does not respect furrows and ridges.[20]

Subcutaneous fungal infections

Subcutaneous mycoses are a heterogenous group of disorders and caused by fungi which infect skin and subcutaneous tissue. The common subcutaneous mycoses are sporotrichosis, mycetoma, chromoblastomycosis, phaeohyphomycosis, and basidiobolomycoses. Diagnosis of these conditions are based on clinical features, histopathology, and microbiological confirmation. Preliminary observation on dermoscopy of some conditions have been made and may be helpful in generating differential diagnosis.


It is chronic infection of subcutaneous tissue caused by fungi (eumycetoma) or filamentous bacteria (actinomycetoma). Mycetoma is generally seen in people who walk barefoot and presents with painless or minimally painful, gradually progressive swelling involving feet with presence of discharging sinus and grains. Dermoscopy of eumycotic mycetoma shows yellow globules, red structureless areas, white superficial scales, and dotted vessels [Figure 22]. It can be used for treatment monitoring as there is reduction in white globules and red structureless areas on treatment. Dermoscopy of actinomycetoma shows yellow globules, white scales, red globules, and white structureless areas. These findings are mere observations and it is not possible to differentiate actinomycetoma from eumycetoma and even from other conditions like nocardiosis on dermoscopy.[21],[22]{Figure 22}

Sporotrichosis is a subcutaneous mycoses caused by dimorphic fungus Sporothrix schenkii. It presents with erythematous papules and plaques with or without central ulceration in linear distribution. Dermoscopy shows yellowish structureless areas, arborizing telangiectasia, and white scar-like areas [Figure 23].[23] {Figure 23}

 Bacterial Infections

Bacterial infections of skin are common and usually diagnosed on clinical grounds. Confirmation is done using gram stain and culture. Impetigo is caused by staphylococcus and presents with honey-colored crusts, most commonly over face. Dermoscopy shows peripheral scaling, yellow crusts, and dotted vessels. Folliculitis presents with pustules, dermoscopy may help in diagnosis when pustule is not prominent. It shows folliculocentric lesion with pustule around hair follicle and surrounding red dots and clods [Figure 24].[24] {Figure 24}

Pitted keratolysis

It is caused by gram positive organism Kytococcus sedentarius, which releases keratin dissolving enzymes to cause pits in the stratum corneum and presents with foul odor. It is more common in patients with hyperhidrosis. Dermoscopy enhance the visualization of shallow crater like irregular pits [Figure 25].[25] {Figure 25}

Trichomycosis axillaris

It is caused by Corynobacterium spp tenuis and flavascens and presents with yellowish concretions around hair shaft and malodor. Dermoscopy shows yellowish white masses around the hair shaft. Pediculosis and Piedra are clinical differential diagnosis [Figure 26].[26] Piedra is a superficial fungal infection involving hair shaft. White Piedra is caused by Trichosporon spp and characterized by multiple white nodules along the hair shaft. Dermoscopy shows presence of ovular white masses along hair shaft. Black Piedra is caused by Piedraia hortae and presents with black colored firm nodules attached to hair shaft. Dermoscopy shows dark concretions attached to hair shafts.[27]{Figure 26}

 Parasitic Infections


Cutaneous leishmaniasis (CL) is endemic in certain parts of India. Leishmania tropica and Donovani are common causative organisms for CL. It presents with erythematous papule, plaque, or nodulo-ulcerative lesion on exposed areas. The diagnosis is based on demonstration of amastigote form in smear and confirmation by culture. Delayed diagnosis may result in unnecessary morbidity as ulcer heals with atrophic scar if not diagnosed and treated promptly. Dermoscopy may help in diagnosis of CL. The dermoscopic features most commonly described in CL are: generalized erythema, yellow tears (yellow oval shaped structures), erosion and vascular features-like dotted vessels, glomerular vessels, and arborizing telangiectasia [Figure 27].[28] {Figure 27}

Post kala ajar dermal leishmaniasis is a late cutaneous manifestation of visceral leishmaniasis caused by Leishmania donovani. It presents with papulo-nodular erythematous plaques with facial involvement or symmetrically distributed hypopigmented macules. Dermoscopy of papules and plaques have been described as presence of generalized erythema, scaling, and yellow tears.[29]


Dermoscopy is a useful adjunct in diagnosis of infections and infestations. Some findings are characteristic and help in rapid diagnosis of diseases like scabies and pediculosis. However, many findings are preliminary observations and require further evaluation in larger studies to confirm. Entomodermoscopy as a science is progressing and will be helpful in diagnosis and treatment monitoring especially in resource limited setting where culture and other serological test may not always be possible.

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Conflicts of interest

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