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MESSAGE FROM PRESIDENT OF IADVL |
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Special Message |
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HR Jerajani DOI:10.4103/2229-5178.73246 PMID:23130180 |
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EDITORIAL |
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From the virtual desk of the editor |
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Shyam B Verma DOI:10.4103/2229-5178.73247 PMID:23130181 |
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ORIGINAL ARTICLES |
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The skin on the move but cold adapted: Fundamental misconceptions in the laboratory and clinic |
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Terence J Ryan DOI:10.4103/2229-5178.73248 PMID:23130182The skin is constantly on the move and at a temperature below 37ºC. The epidermis is a factory, and its blood supply and lymphatic drainage, as well as adipose tissue, are much dependent on movement and influenced by cooling. Neither histopathology (still pictures) nor in vitro studies at 37ºC reflect the true picture. Recent publications neglect older literature exploring these issues. |
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Studies on comparison of the efficacy of terbinafine 1% cream and butenafine 1% cream for the treatment of Tinea cruris |
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Sudip Das, JN Barbhuniya, Indranil Biswas, S Bhattacharya, PK Kundu DOI:10.4103/2229-5178.73249 PMID:23130183Background: In this study, 76 male patients aged between 18 and 61 years affected with Tinea cruris attending the outpatient department of NRS Medical College during a 1-year period were selected. Materials and Methods: The patients were divided into two groups as Regimen I (n 37) and Regimen II (n 39) who were treated with Terbinafine (gr I) cream and Butenafine (gr II) cream, respectively. Results: The predominant pathogen was found to be Trichophyton rubrum in 99% of cases. Mycological cure, overall cure and effective treatment were evaluated on 7, 14 and 42 days. Conclusions: From the study, it was found that Butenafine produced the quickest result and primary efficacy end points were much higher with Butenafine cream than that of Terbinafine cream and this difference was statistically significant (P < 0.01). |
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CASE REPORTS |
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Infantile systemic hyalinosis: A case report and review of literature |
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Bhushan Madke, Vidya Kharkar, Sunanda Mahajan, Siddhi Chikhalkar, Uday Khopkar DOI:10.4103/2229-5178.73250 PMID:23130184We report a case of infantile systemic hyalinosis in a 3.5-month-old male child born out of consanguineous marriage. He presented with multiple brownish raised lesions over bony prominences. He had also developed difficulty in movement of limbs and as a result developed severe flexion joint contractures. There was history of similar complaints in elder sibling who died at the age of 5 months due to repeated episodes of pneumonia. Skin biopsy from one of the papulonodular lesions showed increased amount of amorphous hyaline matrix, which was Periodic Acid Schiff positive with scattered fibroblasts. Though classical, we report this case for its rarity in western India. |
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Lapatinib-induced acute generalized exanthematous pustulosis |
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Chembolli Lakshmi, Suma Pillai, CR Srinivas DOI:10.4103/2229-5178.73251 PMID:23130185Acute generalized exanthematous pustulosis (AGEP) is a pustular eruption, mainly drug induced often accompanied by fever and neutrophilic leukocytosis presenting as scarlatiniform erythema over the flexures evolving into numerous tiny non follicular pustules. We present a case report of a 56-year old woman, who had undergone mastectomy, treated with lapatinib for metastatic disease, and who presented with multiple erythematous papules and plaques with peripheral pustules. She also developed painful pyogenic granuloma-like lesions over the pulp of toe and over the proximal nail folds.All the lesions subsided following withdrawal of lapatinib. Although AGEP has been reported with imatinib (a multikinase inhibitor), there have been no reports of serious reactions with lapatinib, an EGFR inhibitor. This case could represent the first case report of AGEP to the EGFR inhibitor, lapatinib. |
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Darier-White disease in siblings responding to isotretinoin |
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Ramesh M Bhat, Krithi Raviraj Ullal, Anita Caroline Pinto, D Sukumar DOI:10.4103/2229-5178.73252 PMID:23130186Darier-White disease (keratosis follicularis) is a rare disorder of keratinization involving the epidermis, mucous membranes, and nails. It is said to occur as a result of mutation in the ATP2A2 gene located on chromosome 12q23-24.1. In this article we present the case of two brothers with exacerbations of Darier-White disease who responded very well to systemic retinoids without any side effects within 2 weeks of commencing treatment. |
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Acral pityriasis rosea in an infant with palmoplantar lesions: A novel manifestation |
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Vijay Zawar DOI:10.4103/2229-5178.73253 PMID:23130187Indian children often present with atypical forms of pityriasis rosea (PR). We describe a female infant with acrally located eruptions consistent with a clinical diagnosis of PR. This is an extremely rare presentation of the disease. |
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Fibromyxoid sarcoma of the leg |
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Uwe Wollina, Juliane Runge, Jaqueline Schonlebe DOI:10.4103/2229-5178.73254 PMID:23130188A 48-year-old female with an atypical plaque-like lesion of the lower leg is presented in this article. Histologic investigation revealed a rare low-grade fibromyxoid sarcoma (pT1a cN0 cM0; stage Ia) of suprafascial localization. Staging of the patient did not reveal metastatic spread. The tumor was surgically removed with wide safety margins. The defect was closed using a mesh graft transplant and vacuum-assisted closure. Healing was complete. Regular follow-up for at least 5 years is recommended. Besides the rareness of this tumor, this case is also remarkable because of the localization on the lower leg and the suprafascial soft tissue. |
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Generalized eruptive histiocytoma |
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Kamal Aggarwal, Sanjeev Gupta, Vijay Kumar Jain, Rajeev Sen, Sunita Gupta DOI:10.4103/2229-5178.73255 PMID:23130189We are reporting a 62 year old male, who over a period of 1 year, developed a symmetric eruption of hundreds of brownish papules, with spontaneous regression of some lesions. The clinical and histopathological findings were compatible with the diagnosis of generalized eruptive histiocytoma. |
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Hematohidrosis: A rare clinical entity |
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Raksha M Patel, Stuti Mahajan DOI:10.4103/2229-5178.73256 PMID:23130190Hematohidrosis is a rare clinical condition of sweating blood. A 13-year-old boy was presented to the department of dermatology with a history of spontaneous bleeding from skin since January 2007. During examination, it disappeared as soon as it was mopped leaving behind no sign of trauma only to reappear within a few seconds. This confirms that it was sweating of blood and not bleeding. Bleeding time, clotting time and prothrombin time was normal. Patient was diagnosed with hematohidrosis clinically by exclusion, confirmed by benzidine test, biochemical and microscopic examination of fluid. At present, no treatment is available for this condition. Etiology is unknown till date. Stress may be a precipitating factor. |
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Papillon-Lefevre syndrome with pseudoainhum |
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P Ashwani, K Swapna, M Sailaja Rani, B.S.N Reddy DOI:10.4103/2229-5178.73257 PMID:23130191An interesting episode of Papillon-Lefevre syndrome in a 25-year-old female with diffuse palmoplantar keratoderma, periodontitis and pseudoainhum of the toes is reported for academic interest. Her skin lesions improved with topical keratolytics and oral retinoid (acitretin) whereas periodontic problems showed significant improvement with systemic antibiotics and proper implementation of oral hygienic measures. She is undergoing oral rehabilitation with orthodontic surgical procedures. |
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Idiopathic calcinosis cutis of the penis  |
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Ram Tainwala, YK Sharma, Niti Gaur DOI:10.4103/2229-5178.73258 PMID:23130192Calcification of the skin occurs in four main forms namely dystrophic, metastatic, iatrogenic and idiopathic. Idiopathic calcinosis cutis of the penis is exceedingly rare as only five cases have been reported till date to the best of our knowledge. Herein, we present another case of this rare entity in a 29-year old man and discuss its probable pathogenic origin. |
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Early prenatal syphilis |
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Santosh Rathod, Bela Shah DOI:10.4103/2229-5178.73259 PMID:23130193Syphilis in pregnancy still remains a challenge despite the availability of adequate diagnostic tests for serological screening and penicillin therapy. We report a case of 2 month old female infant who presented with runny nose, papulosquamous lesions over both palms and soles and perianal erosions since 1 month after birth. Cutaneous examination revealed moist eroded areas in the perianal region and fine scaly lesions over palms and soles. Radiograph of both upper limbs and limbs revealed early periosteal changes in lower end of humerus and lower end of tibia. Diagnosis of early pre-natal syphilis was confirmed by Child's Serum Rapid Plasma Reagin Antibody test [S.RPR] being positive with 1:64 dilution while that of mother was 1:8. |
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LETTERS TO EDITOR |
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Complication of dimple creation  |
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Sanjay Saraf, Ramesh Pillutia DOI:10.4103/2229-5178.73260 PMID:23130194 |
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Progressive and symmetric erythrokeratoderma of adult onset: A rare case |
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Smitha Prabhu, Shrutakirthi D Shenoi, Sathish B Pai, Sripathi Handattu, Bipin Bhattachan DOI:10.4103/2229-5178.73261 PMID:23130195 |
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Fexofenadine in higher doses in chronic spontaneous urticaria |
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Kiran V Godse, Nitin J Nadkarni, Gaurang Jani, Sunil Ghate DOI:10.4103/2229-5178.73262 PMID:23130196 |
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Multiple coalescing herald patches |
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Ashish Singh, S Ambujam, S Srikanth, GV Seethalakshmi DOI:10.4103/2229-5178.73263 PMID:23130197 |
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SKINDIA QUIZ - 1 |
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Erythematous, firm, papular eruptions involving the face, neck and chest |
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Abhay Mani Martin, P Sugathan DOI:10.4103/2229-5178.73264 PMID:23130198 |
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OPINIONS/EXPERIENCES/TIPS AND TRICKS |
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Cost-effective use of scalp lotions-Some points to ponder |
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Karthika Natarajan, CR Srinivas DOI:10.4103/2229-5178.73265 PMID:23130199 |
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Sad confusion of look-alike tablets |
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Bhanu Prakash DOI:10.4103/2229-5178.73266 PMID:23130200 |
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THROUGH THE LENS |
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Carotenoderma |
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KT Ashique DOI:10.4103/2229-5178.73267 PMID:23130201 |
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MESSAGE FROM DR. T. GOPINATHAN |
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Reminiscences |
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Gopinathan Thekkepat DOI:10.4103/2229-5178.73268 PMID:23130202 |
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BOOK REVIEW |
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History of the IADVL |
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Rui J Fernandez |
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