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Access statistics : Table of Contents
2019| May-June | Volume 10 | Issue 3
Online since
May 17, 2019
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REVIEW ARTICLES
What is new in narrow-band ultraviolet-B therapy for vitiligo?
Urmi Khanna, Sujay Khandpur
May-June 2019, 10(3):234-243
DOI
:10.4103/idoj.IDOJ_310_18
PMID
:31149564
Vitiligo is an acquired disorder of skin pigmentation that produces significant psychological impact especially in those with skin of color. Narrow-band ultraviolet B (NB-UVB) therapy, which was first used in vitiligo in 1997 by Westerhof and Nieuweboer-Krobotova, has emerged as one of the safest and most effective therapy for this dermatosis. The light source used for NB-UVB phototherapy is the TL-01 lamp, and the most common model of the NB-UVB phototherapy device is the upright in-office booth or chamber which has 24–48 such lamps. In recent years, there have been several advances in the understanding of the mechanism of action of NB-UVB and the use of combination treatments, many of which increase the efficacy of NB-UVB. In 2017, the Vitiligo Working Group made vital recommendations on the dosage, frequency, and safety of NB-UVB in vitiligo. Furthermore, home phototherapy devices are gaining popularity as they lead to an improved patient compliance. There is still need for large multicenter randomized controlled trials to assess benefits of home phototherapy in vitiligo and studies investigating additional benefits of phototherapy following surgical therapy.
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11,762
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LETTERS TO THE EDITOR
Pressure to publish: Index copernicus and predatory journals are helping (?) academicians
Himel Mondal, Shaikat Mondal
May-June 2019, 10(3):332-334
DOI
:10.4103/idoj.IDOJ_225_18
PMID
:31149587
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7,320
368
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REVIEW ARTICLES
Newer treatment modalities in epidermolysis bullosa
Leena Bruckner-Tuderman
May-June 2019, 10(3):244-250
DOI
:10.4103/idoj.IDOJ_287_18
PMID
:31149565
The term epidermolysis bullosa (EB) refers to a group of hereditary skin blistering diseases. The group is clinically and genetically heterogeneous, but all EB forms are associated with mechanically induced skin blistering and fragility. The causative gene mutations of most EB types are known. The current international consensus classification contains four main types: EB simplex (EBS), junctional EB (JEB), dystrophic EB (DEB), and Kindler syndrome (KS). The classification is based on the morphological level of blister formation. In EBS, the split is intra-epidermal, in JEB along the basement membrane and in DEB below the basement membrane. In Kindler syndrome, the dermal-epidermal junction is disorganized, and blisters can occur on all three levels. Each major EB type has further subtypes which may differ in terms of their genetic, biological or clinical characteristics. Traditionally, EB treatments have been symptomatic, but increasing understanding of disease etio-pathogenesis is facilitating development of novel evidence-based therapy approaches. First gene- and cell-based therapies are being tested at preclinical level and in clinical trials. New knowledge on secondary disease mechanisms has led to development and clinical testing of urgently needed symptom-relief therapies using small molecules and biologicals.
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4,379
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BRIEF REPORTS
Lichen planus pigmentosus: A clinico-etiological study
Vibhu Mendiratta, Sarita Sanke, Ram Chander
May-June 2019, 10(3):288-292
DOI
:10.4103/idoj.IDOJ_253_18
PMID
:31149573
Introduction:
Lichen planus pigmentosus (LPP) is a distinct clinical entity commonly encountered in the Indian population.
Aim:
To study the clinicoetiological profile of LPP at a tertiary care hospital.
Methods:
A total of 100 patients with clinically and histopathologically confirmed diagnosis of LPP were included. Demographic details including the age of onset, duration of disease, symptoms, and family history were obtained. History regarding any precipitating factors, cosmetics, drug intake, and associated cutaneous or systemic diseases was taken. Clinical examination of the skin, oral cavity, hair, and nails was carried out.
Results:
Of the total 100 patients, 56 (56%) were females and 44 (44%) males with age ranging from 18 to 54 years (mean age - 31.23 years). The duration of disease ranged from 2 to 60 months with a mean of 19.31 months. Cosmetic disfigurement (68%) was the commonest complaint, followed by itching (41%) while, 30% of the patients were asymptomatic. History of topical mustard oil and hair dye application was present in 62% and 48% of the cases each. Other topicals included perfumes (24%), aftershave lotion (36%), and cosmetics (20%). Face (54%) and neck (48%) were the commonest sites affected, followed by upper back (36%), upper limbs, and chest (each 32%). A total of 11 patients showed only flexural involvement. The commonest pattern of pigmentation was diffuse (56%) followed by reticular in 16%. The color of the pigmentation varied from slate grey to brownish-black in varying proportions. A positive association was found between hypothyroidism with diffuse LPP where the
P
value was <0.001.
Conclusion:
LPP is a distinct clinical entity caused by diverse etiological factors and shows varied clinical patterns. All the patients should be advised to stop using mustard oil/henna/hair dye/after shave lotions and cosmetics. Hypothyroidism can be considered to be a disease associated with LPP and all the patients should be investigated for the same.
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EDITORIAL
Antifungal drug susceptibility testing of dermatophytes: Laboratory findings to clinical implications
Sunil Dogra, Dipika Shaw, Shivaprakash M Rudramurthy
May-June 2019, 10(3):225-233
DOI
:10.4103/idoj.IDOJ_146_19
PMID
:31149563
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ORIGINAL ARTICLES
The menace of superficial dermatophytosis on the quality of life of patients attending referral hospital in Eastern India: A cross-sectional observational study
Nibedita Patro, Maitreyee Panda, Ajaya K Jena
May-June 2019, 10(3):262-266
DOI
:10.4103/idoj.IDOJ_342_18
PMID
:31149568
Background:
Superficial dermatophytic infections have come up with multiple challenges and comorbidities recently regarding its chronic and recurrent course.
Aims:
The present study aims at measuring the impact of the disease on the quality of life (QoL) of the patients.
Methods:
A cross-sectional observational study was conducted over 6 months. The patients attending the dermatology outpatient department were recruited after screening and were made to fill up the Dermatology Life Quality Index (DLQI) and 5D-pruritus scale questionnaires. The
P
value was calculated and data were compared using the Pearson's correlation coefficient.
Results:
A total of 294 patients were studied. The effect on QoL was estimated to be moderate [males, ≤10% body surface area (BSA) involvement, ≤6 months duration, low and medium socio-economic status (SES)] to very large (females, >10% BSA involvement, >6 months duration, high SES, and medium and high educational status) according to the DLQI scoring and correlated strongly with the disability scoring in 5D-pruritus scale (
r
= 0.802,
P
< 0.0001).
Limitations:
Small sample size of the study may not reflect the impact on general population, urging the need for multicenter studies.
Conclusions:
Although considered previously as a simple fungal infection, the present state of superficial dermatophytosis has emerged as a social, psychological, and economic burden on the society.
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Prescription and usage pattern of topical corticosteroids among out-patient attendees with dermatophyte infections and its analysis: A cross-sectional, survey-based study
Raju G Chaudhary, Santoshdev P Rathod, Ashish Jagati, Kalgi Baxi, Akshay Ambasana, Disha Patel
May-June 2019, 10(3):279-283
DOI
:10.4103/idoj.IDOJ_335_18
PMID
:31149571
Background:
There is scarce scientific data on topical corticosteroids (TCS) prescription by non-dermatologists including registered medical practitioners, ayurvedic, homeopathic practitioners, and over-the-counter (OTC) use of TCS-containing creams.
Objective:
The main objective of this study is to analyze the prescription and usage pattern of topical steroids among out-patient attendees with dermatophyte infection. To study health-seeking behavior of patients with dermatophyte infections.
Material and Methods:
An open, cross-sectional, duration-based study of 3 months. Inclusion criteria: Patients with dermatophytosis having a history of topical steroid application; either prescribed or purchased OTC and used themselves. Exclusion criteria: Patients who were not willing to give informed consent. Patient's data like socio-demographic profile, duration, frequency, site of application, contents of the topical cream used, prescriber information, and patients' desire to continue the use of topical steroids were recorded.
Results:
Total of 18.40% (
n
= 503) patients were already using cream-containing TCS at the time of presentation to the tertiary dermatology care center. The study shows that almost half of the patients (48.90%) were using unprescribed TCS. Registered medical practitioners were the most common source of TCS creams prescription (59.92%) in the prescribed group, while 26.07% patients were prescribed TCS by dermatologists. Clobetasol propionate (47.91%), was most common steroid agent used.
Conclusion:
Patients are able to get “prescription-only” drugs as OTC products. Such OTC use of TCS puts patients at risk of steroid modified dermatophytosis and topical steroid damaged skin. Even dermatologists may be culprit in creating menace of steroid abuse.
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CASE REPORTS
Cutaneous botryomycosis in immunocompetent patients: A case series
Chandra S Sirka, Gaurav Dash, Swetalina Pradhan, Subhasini Naik, Arpita N Rout, Kananbala Sahu
May-June 2019, 10(3):311-315
DOI
:10.4103/idoj.IDOJ_370_18
PMID
:31149580
Botryomycosis is a rare chronic suppurative bacterial infection of skin and viscera mostly reported in immunocompromised adults. Most of published literature on botryomycosis are case reports. Though morphological presentation of cutaneous botryomycosis has been described as nodules, sinus, abscesses, and ulcers discharging seropurulent exudates, sequential evolution of lesions is not clear. We report a series of three cases of cutaneous botryomycosis in immunocompetent patients (one child and two adults). Two cases had localized lesion, while adult male had lesions in a sporotrichoid distribution. In all cases the lesions evolved in the form of appearance of subcutaneous swelling which later on developed multiple nodules and papules on surface which either developed erosion, ulceration or sinus on surface associated with seropurulent discharge. The organisms isolated from discharge and tissue culture were coagulase negative staphylococcus and methicillin sensitive
staphylococcus aureus
. All cases were treated with monotherapy of sensitive systemic antibiotic. Two patients fully recovered and one lost to follow-up in the middle of therapy.
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1,954
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ORIGINAL ARTICLES
Association of acanthosis Nigricans and insulin resistance in indian children and youth – A HOMA2-IR based cross-sectional study
TM Nithun, P. S. S Ranugha, Jayadev B Betkerur, Veeranna Shastry
May-June 2019, 10(3):272-278
DOI
:10.4103/idoj.IDOJ_303_18
PMID
:31149570
Introduction:
The American Diabetes Association includes acanthosis nigricans (AN) as an indicator of diabetes mellitus risk in overweight youth entering puberty. Some argue that AN is not an independent predictor of insulin resistance (IR), when body mass index (BMI) is controlled for. There is a paucity of studies on the association of AN and IR among children and young adults from India. Homeostatic model assessment-IR (HOMA2-IR), a computerized updated model, which is supposed to be superior to HOMA1-IR, has rarely been used for quantification of IR.
Methods:
Sixty cases (irrespective of BMI), aged 2–24 years with AN, and 30 age- and sex-matched normal weight controls were included. A thorough clinical examination and grading of AN was done. BMI, fasting glucose levels, and fasting insulin levels were measured for all. HOMA-IR calculator V.2.2.3 was used to calculate IR. Those with HOMA 2-IR >1.8 were considered insulin-resistant. Lifestyle modifications were advised for patients with IR. Results: The mean HOMA2-IR value in cases and controls was 2.422 and 1.322, respectively, which was statistically significant. Overweight and obese cases had 2.5 and 11.25 times higher risk of having IR, respectively, by logistic regression. The association of AN with IR was found to be statistically significant in normal weight cases when compared with controls (
P
= 0.045). Grade 4 of neck severity (
P
= 0.007), Grade 3 of neck texture (
P
= 0.001), and Grade 4 of axillary severity (
P
= 0.001) of AN were found to be significantly associated with IR.
Limitations:
The relatively small sample size may not reflect the accuracy of AN as a marker of IR.
Conclusion:
Acanthosis nigricans is associated with IR in both normal and obese. We propose that all children, adolescents, and youth with AN be screened for IR irrespective of BMI. Early identification and prompt lifestyle interventions may prevent or delay the onset of diabetes later.
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Mycetoma: A common yet unrecognized health burden in central India
Gitesh U Sawatkar, Vaishali H Wankhade, Bhagyashree B Supekar, Rajesh Pratap Pratap, Dharitri M Bhat, Supriya S Tankhiwale
May-June 2019, 10(3):256-261
DOI
:10.4103/idoj.IDOJ_358_18
PMID
:31149567
Context:
Mycetoma is a chronic suppurative infective disorder of skin, subcutaneous tissue, fascia, and bones caused by the traumatic inoculation of either fungal (eumycotic) or bacterial (actinomycotic) organisms present in the soil. Triad of tumefaction, discharging sinuses, and grains characterizes the disease.
Aims:
This study was undertaken to study the clinical spectrum and treatment response of mycetoma in central India.
Settings and Design:
It was a retrospective study of clinical and/or biopsy-proven and treated cases of mycetoma from November 2015 to October 2016.
Subjects and Methods:
Medical records of diagnosed and treated mycetoma patients were enrolled retrospectively during November 2015 and October 2016. Case records of patients were evaluated with respect to demographic, clinical, microbiological details, bone involvement, and treatment. Type of therapies and outcome, wherever available, were also assessed.
Statistical Analysis:
Statistical analysis was done using proportion, mean, and percentages.
Results:
Eleven cases (male = 8) were seen during the study period (seven actinomycetoma and four eumycetoma). Foot and lower extremity was the most common site (9/11), whereas upper extremity and forehead were involved in one case each. On culture, the organisms isolated were
Phialophora
and
Fusarium
. Modified Welsch regimen was started in six of seven patients with actinomycetoma, whereas one was started on sulfamethoxazole–trimethoprim and a combination of amoxicillin and clavulanic acid therapy. All four cases of eumycetoma were treated with itraconazole. On follow-up, six cases of actinomycetoma cases showed significant improvement. Two cases of eumycetoma showed mild to moderate improvement and one case required surgical intervention. One case each of actinomycetoma and eumycetoma were lost to follow-up.
Conclusion:
Mycetoma has been recognized as a neglected tropical disease by the World Health Organization, recently. There are very few case reports from the central part of India. Prominent case detection in our study emphasizes the need of larger studies to know the extent of disease in this part of India.
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1,804
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BRIEF REPORTS
Study of causative factors and clinical patterns of periorbital pigmentation
Vibhu Mendiratta, Shiwangi Rana, Rubina Jassi, Ram Chander
May-June 2019, 10(3):293-295
DOI
:10.4103/idoj.IDOJ_158_18
PMID
:31149574
Introduction:
Periorbital hyperpigmentation (POH) is one of the common conditions seen in outpatient department. Despite of its huge prevalence, clinical data regarding its etiology and associations are still insufficient.
Materials and Methods:
We conducted a clinico-investigational study in 50 patients of periorbital pigmentation. A detailed clinical history was recorded, clinical examination and laboratory investigation including complete blood count, vitamin B12 level, and thyroid profile are done.
Results:
The mean age of the patients presenting with periorbital hyperpigmentation was 29.5 years, out of 50 patients 42 (84%) were females and 8 (16%) were males. About 14% patients give positive family history of POH, history of atopy was positive in 30% of patients. History of various other habits like lack of adequate sleep, prolonged exposure to computers, rubbing eyes, and application of various cosmetics were also found to be positive in these patients. The other associated clinical findings were freckles (12%), telengectesia (2%), erythema (2%), and melasma (2%). In maximum (90%) number of patients, both upper and lower eyelids were involved and pigmentation involving >1 cm of eyelid margin was seen in 62% of patients. Laboratory investigations showed anemia in 10% of patients and low serum vitamin B12 in 12%; however, none of the patients has deranged thyroid profile.
Conclusion:
POH has a multifactorial etiology and role of correcting various faulty habits is important factor in its management. Presence of anemia and low serum vitamin B12 levels also points toward need of detailed laboratory evaluation in these patients.
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1,787
271
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LETTERS TO THE EDITOR
Non-pigmented fixed drug eruption caused by ibuprofen
Rochit R Singhal, Niral K Sheth, Pragya A Nair
May-June 2019, 10(3):341-343
DOI
:10.4103/idoj.IDOJ_200_18
PMID
:31149592
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1,446
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ORIGINAL ARTICLES
Association of skin tag with metabolic syndrome and its components: A case–control study from Eastern India
Tapaswini Tripathy, Bhabani S.T.P Singh, Bikash R Kar
May-June 2019, 10(3):284-287
DOI
:10.4103/idoj.IDOJ_238_18
PMID
:31149572
Background:
Skin tags are benign polyps, usually found in the natural folds of the skin. Some studies have found an association of skin tags with obesity, diabetes, hypertension, and atherogenic lipid profile. Metabolic syndrome refers to co-occurrence of these cardiovascular risk factors such as insulin resistance, obesity, dyslipidemia, and hypertension.
Aims and Objectives:
To find out any possible association of skin tags with metabolic syndrome and its components.
Materials and Methods:
A case–control study was conducted including 140 participants. Seventy patients with skin tags were considered cases, and 70 age- and sex-matched patients without skin tags were considered as controls. Various anthropometric and biochemical parameters were compared and analyzed between the two groups.
Results:
Univariate analysis revealed significantly higher waist circumference, high triglyceride, and low high-density lipoproteins (HDLs) in cases compared to controls. The prevalence of diabetes, hypertension, and metabolic syndrome was significantly higher in patients with skin tags, and risk of developing metabolic syndrome was 11.13 times higher in cases compared to controls (
P
< 0.05). Multivariate logistic regression analysis revealed high waist circumference and low serum HDL had significant association with skin tags.
Conclusion:
Risk of development of metabolic syndrome is significantly higher in patients with skin tags. Among the various components of metabolic syndrome, only high waist circumference and low serum HDLs are significantly associated with skin tags.
[ABSTRACT]
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1,332
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CONCISE COMMUNICATIONS
Blueberry muffin baby with cytomegalovirus hepatitis
Vrutika H Shah, Kinjal D Rambhia, Jayesh I Mukhi, Rajesh P Singh
May-June 2019, 10(3):327-329
DOI
:10.4103/idoj.IDOJ_291_18
PMID
:31149585
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1,414
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ORIGINAL ARTICLES
Clinical profile of cutaneous adverse effects of epidermal growth factor receptor inhibitors: A prospective observational study of 76 cases
Neerja Saraswat, Aradhana Sood, Dharmesh Kumar, Rajesh Verma, Kumar Sushil
May-June 2019, 10(3):251-255
DOI
:10.4103/idoj.IDOJ_325_18
PMID
:31149566
Background:
Epidermal growth factor receptor (EGFR) inhibitors are an extensively utilized class of chemotherapeutic agents which form an integral component of treatment in solid organ malignancies such as non-small-cell lung carcinoma, pancreatic carcinoma, colorectal carcinoma, and head and neck carcinoma. It has two subclasses: epidermal growth factor inhibitors (erlotinib) and monoclonal antibody (cetuximab). A wide array of cutaneous adverse effects has been attributed to this class of drugs, such as papulopustular eruptions, paronychia, xerosis, and changes in hair and nails.
Materials and Methods:
A total of 76 cases of various malignancies on EGFR inhibitors who developed cutaneous side effects while on therapy and reported or referred to us by oncologists from January 2017 to January 2018 were included in the study. All the patients who were on other associated medications or radiotherapy were excluded.
Result:
In all, 45 (59.2%) were males and 31 (40.7%) were females. Non-small-cell lung carcinoma was the most common carcinoma in 32 (42.1%) patients, and cetuximab was the most common drug in 29 (38.1%) cases. Papulopustular eruptions were seen in 61 (80.2%) patients, xerosis in 31 (40.7%), mucositis in 6 (7.8%), hair growth problems in 4 (5.6%), and paronychia and pyogenic granuloma in 2 (2.6%) patients each.
Conclusion:
Although most of the skin toxicities associated with EGFR inhibitors can be managed conservatively, a critical analysis of the cases that are significantly affected due to these side effects is required in cohesion with the treating oncologist to improve the therapeutic compliance of the drug.
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1,329
205
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THROUGH THE LENS
Erythrasma of palm: Presentation at the rare site
Angoori Gnaneshwar Rao, Aparna Karanam, Syeda Saba Farheen
May-June 2019, 10(3):356-357
DOI
:10.4103/idoj.IDOJ_249_18
PMID
:31149599
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1,371
151
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Tinea pseudoimbricata: A striking “ring-within-a-ring” form of corticosteroid-modified dermatophytosis
Naveen Kumar Kansal
May-June 2019, 10(3):354-355
DOI
:10.4103/idoj.IDOJ_169_18
PMID
:31149598
[FULL TEXT]
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1,230
172
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LETTERS TO THE EDITOR
Hematohidrosis – A rare case
T Pari
May-June 2019, 10(3):334-335
DOI
:10.4103/idoj.IDOJ_252_18
PMID
:31149588
[FULL TEXT]
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1,237
154
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THROUGH THE DERMOSCOPE
Dermoscopy of keratoacanthoma centrifugum marginatum
Keshavmurthy A Adya, Arun C Inamadar, Aparna Palit
May-June 2019, 10(3):360-362
DOI
:10.4103/idoj.IDOJ_134_18
PMID
:31149601
[FULL TEXT]
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1,257
109
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ORIGINAL ARTICLES
Transepidermal water loss in psoriasis: A case-control study
Vrushali N Nikam, Rochelle C Monteiro, Sukumar Dandakeri, Ramesh M Bhat
May-June 2019, 10(3):267-271
DOI
:10.4103/idoj.IDOJ_180_18
PMID
:31149569
Context:
Psoriasis is a common papulosquamous disorder characterized by increased epidermal turnover resulting in excessive skin shedding and a compromised barrier function of the skin. Transepidermal water loss (TEWL) is an effective and non-invasive way to measure the barrier function in this condition.
Aims:
To measure the physiological changes in the skin barrier function in psoriasis by measuring the extent of TEWL. To study the differences in TEWL in pathologically involved and uninvolved skin in psoriasis. To compare the TEWL in skin lesions in psoriatic patients and site matched controls.
Subjects and Methods:
To determine the barrier quality of the stratum corneum, we performed TEWL measurements using the closed chamber evaporation method (VapoMeter Delfin Technologies, Kuopio, Finland). The ambient temperature ranged between 21°C and 24°C, with a mean relative humidity range of 39%–50%. In total, four sites were measured for all the 50 cases, two involved plaques on the body were selected for the study of lesional psoriatic skin, and the standard sites of ankle and elbow were measured irrespective of being involved or uninvolved with psoriatic skin. TEWL measurements in controls were site matched. Statistical testing was done using SPSS ver. 17. The interval scale data were tested for normality using Shapiro-Wilk test, and between groups testing was done using Mann-Whitney test.
Results:
The TEWL was higher among the cases in all the four measured areas compared to the controls, thus showing overall impaired skin barrier function in psoriatic skin. In addition, among the cases, the involved sites show higher TEWL in comparison to the uninvolved skin. This is highly suggestive that plaques of psoriasis have reduced water holding capacity.
Conclusions:
Psoriasis is a dermatosis with overall compromise of the skin barrier function exhibiting exponential TEWL in lesional skin, with increased TEWL over non-lesional skin as well. Thus, it may be concluded that TEWL is an effective, non-invasive and objective method in assessment of skin barrier function.
[ABSTRACT]
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1,092
207
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CASE REPORTS
H syndrome - A case report
Patrick Yesudian, KN Sarveswari, KJ Karrunya, Kuruvilla Thomas
May-June 2019, 10(3):300-302
DOI
:10.4103/idoj.IDOJ_187_18
PMID
:31149577
This case report describes a case of H syndrome with characteristic cutaneous hyperpigmentation, hypertrichosis, sclerodermatous thickening, and multisystem involvement such as hearing loss and heart anomaly in an Indian patient. There are around 100 cases of this rare, autosomal recessive genodermatosis reported in the literature, out of which 10 cases are from the Indian population. The aim of this paper is to increase awareness about this novel inherited form of histiocytosis and insist on the role of dermatologists to identify such patients in our population where consanguinity is prevalent.
[ABSTRACT]
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1,097
184
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LETTERS TO THE EDITOR
A case of warty dyskeratoma on an unusual location
Kinjal D Rambhia, Meena B Makhecha
May-June 2019, 10(3):343-345
DOI
:10.4103/idoj.IDOJ_473_18
PMID
:31149593
[FULL TEXT]
[PDF]
[Mobile Full text]
[EPub]
[PubMed]
985
160
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SKINDIA QUIZ
SkIndia Quiz 51: Asymptomatic firm cerebriform swelling over the lower back
Sanjay Singh, Nimitha Parambath, Savita Yadav
May-June 2019, 10(3):349-350
DOI
:10.4103/idoj.IDOJ_190_17
PMID
:31149596
[FULL TEXT]
[PDF]
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[EPub]
[PubMed]
1,027
109
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DERMATOLOGY PEARLS
A simple interdigital separator to aid the management of tinea pedis
Feroze Kaliyadan, Karalikkattil T Ashique
May-June 2019, 10(3):347-348
DOI
:10.4103/idoj.IDOJ_69_19
PMID
:31149595
[FULL TEXT]
[PDF]
[Mobile Full text]
[EPub]
[PubMed]
979
127
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RESEARCH SNIPPETS
Basic understanding of study types and formulating research question for a clinical trial
Dipankar De, Sanjay Singh
May-June 2019, 10(3):351-353
DOI
:10.4103/idoj.IDOJ_56_19
PMID
:31149597
[FULL TEXT]
[PDF]
[Mobile Full text]
[EPub]
[PubMed]
950
149
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CASE REPORTS
Cutaneous pseudolymphoma secondary to facial thread lift procedure
Meena Makhecha, Tishya Singh, Tulika Yadav, Meeth Atawane
May-June 2019, 10(3):322-324
DOI
:10.4103/idoj.IDOJ_166_18
PMID
:31149583
Pseudolymphoma, refers to a heterogeneous group of benign reactive T-cell or B-cell lymphoproliferative processes of diverse causes that simulate cutaneous lymphomas clinically and/or histologically. Thread lift involves the elevation of sagging tissues for rejuvenating the face, which loses its elasticity and volume as one ages, by stimulating the production of new collagen and elastin. The incidence of complications with thread lift is comparatively low, like small ecchymosis, mild erythema, mild transitory hyperesthesia, and mild postoperative tumefaction.
[1]
Cutaneous pseudolymphoma secondary to facial thread-lift procedure has not been previously reported as a complication. In this case report, we will be presenting cutaneous pseudolymphoma as one of the complications of thread-lift procedures and will be speculating its pathogenesis.
[ABSTRACT]
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865
198
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Lymphocutaneous sporotrichosis of face with verrucous lesions: A case report
Santwana Verma, Ghanshyam Verma, Renu Rattan
May-June 2019, 10(3):303-306
DOI
:10.4103/idoj.IDOJ_272_18
PMID
:31149578
Sporotrichosis is a cutaneous mycosis caused by a dimorphic fungus,
Sporothrix schenckii
species complex clinically presenting as lymphocutaneous, fixed, or disseminated forms. A typical lesion is an erythematous papule, noduloulcerative lesion usually occurring at the site of penetrating trauma, mostly on the extremities. Verrucous lesion is an unusual presentation of sporotrichosis which can mimic the verrucous lesions seen in chromoblastomycosis, tuberculosis verruca cutis/lupus vulgaris (TBVC/LV), cutaneous leishmaniasis, and blastomycosis leading to diagnostic dilemma. Herein, we describe a case of facial verrucous sporotrichosis in a child from sub-Himalayan region.
[ABSTRACT]
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896
148
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THROUGH THE DERMOSCOPE
Mucoscopy of mucocele
Ishmeet Kaur, Deepak Jakhar, Priyanka Anand
May-June 2019, 10(3):358-359
DOI
:10.4103/idoj.IDOJ_96_18
PMID
:31149600
[FULL TEXT]
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900
109
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CASE REPORTS
EGFR inhibitors-related panniculitis: A new side effect
Sofia Lopes, Ana Nogueira, Joana Pardal, Filomena Azevedo
May-June 2019, 10(3):319-321
DOI
:10.4103/idoj.IDOJ_273_18
PMID
:31149582
Epidermal growth factor receptor (EGFR) inhibitors are widely used in the treatment of advanced malignancies, and their skin toxicity is frequent and well recognized in the literature. We report the case of a 69-year-old patient with a history of adenocarcinoma of the lung treated with several EGFR inhibitors and the development of skin lesions compatible with panniculitis. The reproducibility of the lesions with different inhibitors reinforces the causal relationship with the drug, representing the first report in the literature of this side effect.
[ABSTRACT]
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838
145
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An interesting coexistence of multifocal hypertrichosis and hirsutism in hypomelanosis of ito
Vibhu Mendiratta, Anuja Yadav, Rashi Pagnti, Ram Chander
May-June 2019, 10(3):316-318
DOI
:10.4103/idoj.IDOJ_173_18
PMID
:31149581
Hypomelanosis of Ito (HOI) is a sporadic disorder characterized by naevoid hypomelanosis in association with neurological, musculoskeletal, and other systemic defects. Localized hypertrichosis has been reported in HOI, however, multifocal hypertrichosis along with hirsutism in HOI are rare. We report an interesting coexistence of multifocal hypertrichosis and hirsutism in a 7-year-old girl with HOI.
[ABSTRACT]
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827
115
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MUSINGS, OPINIONS, TIPS AND EXPERIENCES
Re-discovering sandalwood: Beyond beauty and fragrance
Bhattacharjee Rajsmita, Vinay Keshavamurthy
May-June 2019, 10(3):296-297
DOI
:10.4103/idoj.IDOJ_357_18
PMID
:31149575
[FULL TEXT]
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775
147
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CASE REPORTS
Atypical presentation of primary cutaneous CD8 positive aggressive epidermotropic cytotoxic t-cell lymphoma
Aitana R Sanchez, Pedro S Sambucety, Camino P García, Manuel A R. Prieto
May-June 2019, 10(3):298-299
DOI
:10.4103/idoj.IDOJ_257_18
PMID
:31149576
Primary cutaneous CD8 positive aggressive epidermotropic cytotoxic T-cell lymphoma (PCAT) is a rare and heterogeneous entity with less than 100 published cases to date. A 68-year-old man was following up for an inflammatory lichen–lupus overlap dermatosis of 3 years duration. Treatment with methotrexate was started, observing a dramatic change in the skin lesions that became infiltrated plaques and generalized ulcerated tumours distributed over trunk and extremities. Histological study showed marked epidermotropism of CD8 positive cells and monoclonality was demonstrated by the polymerase chain reaction. Diagnosis of PCAT was concluded. Treatment with polychemotherapy was indicated. The PCAT is characterized by a rapid clinical history of generalized papules, plaques, nodules and tumours with frequent ulceration and necrosis. Although it has no pathognomonic clinical features, there are clinical, histological and prognostic data that define them as a group and differentiate them from other lymphomas. Exceptionally, there are cases reported which have been triggered following treatment with immunosuppressive drugs. In our patient we think that PCAT was triggered by the transformation of a pre-existing dermatosis, which had never showed a lymphoproliferative profile in biopsies before. A possible pathogenic mechanism is that in some inflammatory dermatoses, chronic antigenic stimulation in a situation of iatrogenic immunosuppression may favour the development of a malignant clonal T cell.
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742
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Localized cutaneous hyalohyphomycosis by
Fusarium
spp. over a postsurgical scar: Response to fluconazole
Chetan D Rajput, Sunil Lilani, Kiran Paradeshi, Vasudha S Deore
May-June 2019, 10(3):307-310
DOI
:10.4103/idoj.IDOJ_289_18
PMID
:31149579
Hyalohyphomycosis are opportunistic fungal infections caused by fungi with colorless septate hyphae.
Fusarium
is a hyalohyphomycetes which can cause localized or disseminated infections depending on host immunity. Our patient had an infectious lesion over the coronary artery bypass grafting (CABG) scar which was not responding to antibacterial treatment. Further investigations revealed it to be localized cutaneous
Fusarium
infection. The patient was treated with fluconazole 3 mg/kg/day for 3 weeks and responded very well without any recurrence during the next 3 months follow-up. Thus, this case highlights the effectiveness of fluconazole in uncommon fungal infection.
[ABSTRACT]
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793
115
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LETTERS TO THE EDITOR
Guttate leukoderma in darier disease: A rare presentation
Isha Gupta, Surabhi Dayal, Sanjay Kumar
May-June 2019, 10(3):337-340
DOI
:10.4103/idoj.IDOJ_314_18
PMID
:31149590
[FULL TEXT]
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706
138
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Lyme disease - A report of atypical cutaneous sequelae
Sukriti Baveja, Bhavni Oberoi, Deepak Vashisht, Pankaj Das
May-June 2019, 10(3):336-337
DOI
:10.4103/idoj.IDOJ_294_18
PMID
:31149589
[FULL TEXT]
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652
139
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CONCISE COMMUNICATIONS
An unusual morphological and distribution pattern of chronic cutaneous lupus erythematosus
Manju Meena, Ashok Kumar Khare, Lalit Kumar Gupta, Asit Kumar Mittal
May-June 2019, 10(3):325-326
DOI
:10.4103/idoj.IDOJ_115_18
PMID
:31149584
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596
132
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DERMATOLOGY PEARLS
Modification of dermoscopes for difficult to access sites
Feroze Kaliyadan, Abdul W Mohammed
May-June 2019, 10(3):346-346
DOI
:10.4103/idoj.IDOJ_429_18
PMID
:31149594
[FULL TEXT]
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643
81
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CONCISE COMMUNICATIONS
Dermatoscopy in actinomycetoma: An observation
Balachandra S Ankad, Savitha L Beergoudar, Balakrishna P Nikam
May-June 2019, 10(3):330-331
DOI
:10.4103/idoj.IDOJ_268_18
PMID
:31149586
[FULL TEXT]
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514
108
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HISTORY
On the history of angioedema (From Donato to Strübing): A journey for three centuries
Amiya Kumar Mukhopadhyay
May-June 2019, 10(3):363-364
DOI
:10.4103/idoj.IDOJ_410_18
PMID
:31149602
[FULL TEXT]
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470
89
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LETTERS TO THE EDITOR
Prevalence of metabolic syndrome in patients with lichen planus: A cross-sectional study from a tertiary care center
Mahmood Dhahir Al-Mendalawi
May-June 2019, 10(3):340-341
DOI
:10.4103/idoj.IDOJ_331_18
PMID
:31149591
[FULL TEXT]
[PDF]
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[EPub]
[PubMed]
476
83
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Online since 1
st
June, 2010