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   2014| November  | Volume 5 | Issue 5  
    Online since November 13, 2014

 
 
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ORIGINAL ARTICLES
Epidemiological pattern of psoriasis, vitiligo and atopic dermatitis in India: Hospital-based point prevalence
Sorna Kumar, Chitra S Nayak, Tanmay Padhi, Gnaneshwar Rao, Ashwin Rao, VK Sharma, CR Srinivas
November 2014, 5(5):6-8
DOI:10.4103/2229-5178.144499  
Background: The knowledge of the prevalence of common dermatoses will be useful for optimum use of valuable resources of the country. Aim: The aim of the study is to determine the pattern and prevalence of psoriasis, vitiligo and atopic dermatitis (AD) in India. Materials and Methods: This was a hospital-based study conducted on a single day in one medical college each in four zones of India. Results: The point prevalence of dermatological cases was 9.25%. The point prevalence of psoriasis, vitiligo and AD were 8%, 9.98% and 6.75% respectively. Chronic plaque type psoriasis was the most common (50%) clinical pattern. The most common site of involvement of psoriasis was the palms. Stable type of vitiligo was common which accounted for 65.21%. Lower lip was involved in 75% of mucosal vitiligo. Lower limbs were the most common site of onset of vitiligo. AD was most prevalent in the first decade (40.7%). Personal history of atopy was present in (59.5%) patients. Dry skin was present in 92.5% of patients. Conclusions: Our data correlates with previous hospital-based prevalence studies of psoriasis, vitiligo and AD.
  7,201 940 5
CASE REPORTS
Rowell syndrome
Ramesh Y Bhat, Chaitanya Varma, Sonia Bhatt, C Balachandran
November 2014, 5(5):33-35
DOI:10.4103/2229-5178.144526  
Rowell syndrome is a rare disease consisting of erythema multiforme-like lesions associated with lupus erythematosus. The syndrome occurs mostly in middle-aged women. The authors describe the syndrome in a 15-year-old boy who responded well to systemic steroids and hydroxychloroquine.
  7,007 557 4
ORIGINAL ARTICLES
Role of hormones and blood lipids in the pathogenesis of acne vulgaris in non-obese, non-hirsute females
Ola Ahmed Bakry, Rania Mohamed Azmy El Shazly, Shawky Mahmoud El Farargy, Dalia Kotb
November 2014, 5(5):9-16
DOI:10.4103/2229-5178.144506  
Context: Acne vulgaris (AV) is a common disease affecting all ages and ethnic groups. Androgens, skin and serum lipids, inflammatory signaling and regulatory neuropeptides seem to be involved in this multi-factorial process. Aim: The aim of this work was to determine hormonal levels and lipid profile in non-obese, non-hirsute females with AV. Subjects and Methods: A total of 60 non-obese, non-hirsute female cases with different grades of AV and 60 age- and gender-matched healthy volunteers were included. Measurement of serum total and free testosterone, sex hormone binding globulin (SHBG), estradiol and progesterone and blood lipids was done during the luteal phase of the menstrual cycle. Results: Total testosterone, free testosterone (FT) and progesterone levels were significantly higher (P < 0.001 for all) while estradiol levels (P < 0.001) and SHBG (P < 0.01) were significantly lower in cases than controls. Total cholesterol and low density lipoprotein cholesterol (LDL-C) levels were significantly higher (P < 0.001 for both) while high density lipoprotein cholesterol (HDL-C) and apolipoprotein A-1 (ApoA-1) levels were significantly lower (P < 0.001 for both) in cases than controls. Higher values of FT (P = 0.03) and SHBG (P = 0.02) and lower values of estradiol (P = 0.04) levels were significantly in favor of severe acne. Higher values of cholesterol (P < 0.001) and LDL-C (P = 0.03) and lower values of HDL-C (P = 0.01) and ApoA-1 (P = 0.02) levels were significantly associated with severe acne. Conclusion: Changes in hormone levels and lipid profile in non-obese and non-hirsute females with AV should be considered in disease pathogenesis and in treatment prescription of these patients.
  5,882 554 5
THROUGH THE LENS
Pityriasis amiantacea
Lalit Kumar Gupta, Ashok Kumar Khare, Vaishali Masatkar, Asit Mittal
November 2014, 5(5):63-64
DOI:10.4103/2229-5178.144550  
  4,852 319 -
Ehlers-Danlos syndrome
Farhana Tahseen Taj, Vijaya V Sajjan, Dolly Singh
November 2014, 5(5):68-70
DOI:10.4103/2229-5178.144554  
Ehlers-Danlos syndrome (EDS) is a generalized disorder of one element of connective tissue manifesting clinically by fragility and hyperelasticity of the skin and joint laxity. It is a hereditary disorder, the inheritance being usually autosomal dominant with low penetrance. Autosomal recessive and X-linked recessive varieties are also known. First described by Hippocrates in 4 th century B.C., the various clinical types with variable penetrance have been described lately. The number of cases EDS reported in the literature is very meagre. With the available information only about six publications of classic EDS in siblings had been reported in Indian literature.
  4,141 381 1
CASE REPORTS
Chilblain lupus erythematosus in an adolescent girl
Shikha Bansal, Alka Goel
November 2014, 5(5):30-32
DOI:10.4103/2229-5178.144522  
Chilblain Lupus Erythematosus (CHLE) is a rare form of cutaneous lupus erythematosus (LE), more frequently seen in middle aged females. It is characterized by erythematous to violaceous plaques over the acral areas induced by exposure to cold or drop in temperature unlike lesions of lupus erythematosus that worsen with sun exposure. Here, we present a case of chilblain lupus erythematosus in an adolescent girl with few unique features not previously reported.
  3,010 295 -
ORIGINAL ARTICLES
Sexually transmitted infections in women: A correlation of clinical and laboratory diagnosis in cases of vaginal discharge syndrome
Vidyalaxmi Chauhan, Maitri Shah, Sejal Thakkar, Sangita V Patel, Yogesh Marfatia
November 2014, 5(5):1-5
DOI:10.4103/2229-5178.144498  
Aims: This study compares the clinical and laboratory diagnosis of vaginal discharge syndrome. Settings and Design: This cross-sectional study was carried out at the gynaecology outpatient department of a tertiary care hospital in Gujarat, India. Material and Methods: Total of 180 females diagnosed as vaginal discharge or cervicitis based on syndromic approach and were recruited for the study. Their clinical profile was noted and they were investigated for bacterial vaginosis, trichomoniasis, candidiasis, gonorrhoea and chlamydia infection. Results: Lower abdominal pain (35%) followed by burning micturition (23.9%) were the common associated complaints. Bacterial vaginosis was the most common clinical diagnosis, while trichomoniasis was least common. Upon laboratory investigation, 35.6% of cases of vaginal discharge and 12% of cases of cervicitis tested positive. Percentage of cases confirmed by laboratory investigation was 50, 27.8 and 41.7 for bacterial vaginosis, trichomoniasis and candidiasis respectively. Conclusion: Among all the females diagnosed as vaginal discharge syndrome, a very small percentage actually turned out to be positive upon laboratory testing.
  2,621 473 1
CASE REPORTS
Acrokeratosis verruciformis of Hopf in family
Sanjay N Agrawal, Subodhkumar D Jane, Anuprita A Rawal
November 2014, 5(5):17-19
DOI:10.4103/2229-5178.144509  
Acrokeratosis verruciformis of Hopf (AKV) is a rare disorder of keratinization inherited in an autosomal dominant fashion. A 15-year-old female presented with numerous skin-colored papular lesions over the neck as well as dorsa of the hands and feet of 7 years duration. Similar lesions were noted in her mother. Six other members of her family showed similar lesions with similar site of involvement. Presence of characteristic warty papules and histopathology led to diagnosis of a rare condition of acrokeratosis verruciformis.
  2,681 265 -
Segmental vitiligo with segmental morphea: An autoimmune link?
Pravesh Yadav, Taru Garg, Ram Chander, Anita Nangia
November 2014, 5(5):23-25
DOI:10.4103/2229-5178.144517  
An 18-year old girl with segmental vitiligo involving the left side of the trunk and left upper limb with segmental morphea involving the right side of trunk and right upper limb without any deeper involvement is illustrated. There was no history of preceding drug intake, vaccination, trauma, radiation therapy, infection, or hormonal therapy. Family history of stable vitiligo in her brother and a history of type II diabetes mellitus in the father were elicited. Screening for autoimmune diseases and antithyroid antibody was negative. An autoimmune link explaining the co-occurrence has been proposed. Cutaneous mosiacism could explain the presence of both the pathologies in a segmental distribution.
  2,385 380 2
Unilateral nevoid acanthosis nigricans: Uncommon variant of a common disease
Anupam Das, Sabari Bhattacharya, Piyush Kumar, Tirthankar Gayen, Kunal Roy, Nilay K Das, Ramesh C Gharami
November 2014, 5(5):40-43
DOI:10.4103/2229-5178.144529  
Acanthosis nigricans (AN) is a fairly common dermatosis characterized by hyperpigmented velvety plaques, having a predilection for the intertriginous areas. We herein present a case of unilateral nevoid acanthosis nigricans over the left lateral chest, in an adult male. The rarity of documentation of this entity in the world literature prompted us to report the case.
  2,455 233 1
Berardinelli-Seip congenital lipodystrophy in two siblings
T Rao, Kavya Chennamsetty
November 2014, 5(5):20-22
DOI:10.4103/2229-5178.144511  
Berardinelli-Seip congenital lipodystrophy (BSCL) is a very rare autosomal recessive disorder characterized by various dermatological and systemic manifestations such as lipoatrophy, hypertriglyceridemia, hepatomegaly, acanthosis nigricans, and acromegaloid features. BSCL type 2 is more common and severe, with onset in the neonatal period or in early infancy. The locus for BSCL2 has been identified on chromosome 11q13. Early recognition and differentiation from other congenital generalized lipodystrophies help in the initiation of appropriate preventive and therapeutic measures such as lifestyle modification and pharmacotherapy that helps postpone the onset of metabolic syndrome. We report BSCL type 2 in two siblings with several cutaneous manifestations like acanthosis nigricans, hypertrichosis, prominent subcutaneous veins, and increased lanugo hair.
  2,223 283 1
THROUGH THE LENS
Uremic frost
Sujeet Raina, Vivek Chauhan, Rajesh Sharma, Ravi Sharma
November 2014, 5(5):58-58
DOI:10.4103/2229-5178.144545  
  2,283 181 1
CASE REPORTS
Congenital candidiasis
Chintaginjala Aruna, Kolalapudi Seetharam
November 2014, 5(5):44-47
DOI:10.4103/2229-5178.144531  
Congenital candidiasis (CC) is a rare disease with less than 100 cases being reported in the literature. It presents within six days of life with manifestations ranging from localized skin disease to systemic involvement in the form of respiratory distress, sepsis, and death. We report a neonate who presented with diffuse pustular eruption on erythematous background involving face, trunk, and palms within 24 h after birth. Candida albicans was identified in 10% potassium hydroxide (KOH) smear and culture from the pustules. Intravenous fluconazole and topical ketoconazole were given and the condition improved completely in two weeks. CC is rare and needs to be differentiated from other conditions presenting with pustular lesions at birth in order to avoid complications. Early diagnosis and prompt treatment of this condition is important as untreated cases carry a mortality rate of 8-40%.
  2,050 294 1
LETTERS TO THE EDITOR
Unusual presentation of severe pompholyx
Varadraj V Pai, Pankaj Shukla, KN Naveen, Sharat Chandra Athanikar, US Dinesh
November 2014, 5(5):48-49
DOI:10.4103/2229-5178.144532  
  2,008 242 -
THROUGH THE LENS
Multiple papulonodular lesions located over the nasolabial sulcus
Ayse Serap Karadag, Emin Ozlu, Ebru Zemheri, Seyma Ozkanli
November 2014, 5(5):56-57
DOI:10.4103/2229-5178.144543  
  1,999 203 -
CASE REPORTS
Nodular colloid degeneration of the skin: Report of three cases with review and update
Alireza Ghanadan, Kambiz Kamyab-Hesari, Maryam Daneshpajouh, Kamran Balighi, Pedram Normohammadpour
November 2014, 5(5):36-39
DOI:10.4103/2229-5178.144527  
Nodular colloid degeneration (NCD) is a rare dermatological disorder and uncommon type of colloid milium. The degeneration may be related to sun exposure. In this report, three cases, all presenting as multiple plaques and nodules over the nose and the face are depicted. Histologically, these nodular masses were homogeneous, with eosinophilic-cleaved materials expanding the papillary dermis and extending into the deep dermis. Periodic acid Schiff (PAS), crystal violet, and methyl-violet stains highlight the colloid material. All the three cases were finally diagnosed as NCD. NCD could be considered in any case with facial nodules and a long history of sun exposure. We suggest the long-term sun exposure as an etiologic factor; thus sun protection would be the most preventive and available treatment.
  1,929 227 1
LETTERS TO THE EDITOR
Keraunographic tattoo
Deepak Vashisht, Ivaturi Venkata Nagesh, S Vashisht
November 2014, 5(5):52-53
DOI:10.4103/2229-5178.144537  
  1,792 186 -
THROUGH THE LENS
Tendinous xanthoma with familial hypercholesterolemia
Alok Kumar Roy, Sudip Das, Joyeeta Chowdhury, Dulal Bhanja
November 2014, 5(5):59-60
DOI:10.4103/2229-5178.144546  
  1,698 206 1
Half and half nail
Ganesh Avhad, Priyanka Ghuge
November 2014, 5(5):67-67
DOI:10.4103/2229-5178.144553  
  1,466 221 -
CASE REPORTS
Metastatic basal cell carcinoma to the lungs: Case report and review of literature
Henry Benson Nongrum, Debomaliya Bhuyan, Vanlalhuma Royte, Hughbert Dkhar
November 2014, 5(5):26-29
DOI:10.4103/2229-5178.144520  
Basal cell carcinoma is the most common form of skin cancer and it rarely metastasizes. The prevalence of metastatic basal cell carcinoma (MBCC) varies between 0.0028% and 0.55% of all cases. Over 250 MBCC have been reported in the literature. We present a case with large recurrent basal cell carcinoma of the face with radiological and histopathological findings indicating the presence of metastasis to the lungs.
  1,329 195 2
THROUGH THE LENS
Molluscuoid lesions over the body
Pradeep S Nair
November 2014, 5(5):61-62
DOI:10.4103/2229-5178.144548  
  1,179 194 -
Idiopathic congenital true leukonychia totalis
Avhad Ganesh, Ghuge Priyanka
November 2014, 5(5):65-66
DOI:10.4103/2229-5178.144551  
  950 422 -
LETTERS TO THE EDITOR
Buschke-Lowenstein tumor in a patient with decompensated cirrhosis
F. N. U. Shailesh, Nitin Relia, Naga Venkata K Pothineni, Abhishek Agarwal
November 2014, 5(5):54-55
DOI:10.4103/2229-5178.144540  
  1,131 162 -
Marjolin's ulcer: A rare report
Kumar Parimalam, M Vinnarasan, G Senthil, V Arumugakani, BM Amutha
November 2014, 5(5):50-51
DOI:10.4103/2229-5178.144534  
  1,024 189 -
Hypersensitivity reaction to scorpion antivenom
Hossein Sanaei-Zadeh
November 2014, 5(5):51-52
DOI:10.4103/2229-5178.144536  
  859 179 -
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