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   2018| May-June  | Volume 9 | Issue 3  
    Online since May 2, 2018

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Newer topical treatments in skin and nail dermatophyte infections
Kanika Sahni, Sanjay Singh, Sunil Dogra
May-June 2018, 9(3):149-158
DOI:10.4103/idoj.IDOJ_281_17  PMID:29854633
Dermatophytes are amongst the most common causative agents of fungal infections worldwide and widespread in the developing countries. Various studies have found the significantly rising trend of this infection in India especially in last 4-5 years. The growing epidemic of recurrent/chronic dermatophytosis has led to the need for newer antifungal agents and/or preparations. Furthermore, resistance to commonly used topical and oral antifungals has increased alarmingly. Significantly increasing resistance has led to state of anxiety in physicians and significant distress to the patients socially, emotionally, and financially. Newer formulations or newer derivatives of existing drug classes and few newer drug classes are being developed to tackle this menace. Other forms of local therapies including lasers and photodynamic therapy are still in developmental phase and still need to be optimized in terms of dosing schedule, frequency of use and duration of therapy. Moreover, cost of these therapies remained most important obstacle in developing countries like India. We are hereby reviewing the newer formulations of topical therapies and drugs/interventions in experimental phase.
  17,140 1,969 -
Bimatoprost in dermatology
Abhijeet K Jha, Rashmi Sarkar, Uday K Udayan, PK Roy, Amar K Jha, R. K. P Chaudhary
May-June 2018, 9(3):224-228
DOI:10.4103/idoj.IDOJ_62_16  PMID:29854658
Bimatoprost is a prostamide analogue used for treatment of glaucoma in ophthalmology. Surprisingly, the side effects such as increased pigmentation of eyelids and hypertrichosis in patients being treated with prostaglandin analogues for glaucoma have opened new areas of application in various dermatological disorders such as alopecia mainly affecting eyelashes, eyebrows, and vitiligo.
  5,209 448 -
Intense pulsed light therapy for acne-induced post-inflammatory erythema
Minu L Mathew, R Karthik, M Mallikarjun, Soumya Bhute, Aiswarya Varghese
May-June 2018, 9(3):159-164
DOI:10.4103/idoj.IDOJ_306_17  PMID:29854634
Background: Intense pulsed light (IPL) is a comparatively new system of practice in treating acne-induced post inflammatory erythema (PIE) which is a difficult condition to treat, and variations exist in the results from published studies with insufficient or limited scientific evidence of IPL on Indian skin. Aim: To study the efficacy of IPL in the treatment of acne-induced PIE and to document adverse effects of the procedure. Settings and Design: A hospital-based retrospective observational study on 33 patients with acne-induced PIE who completed treatment with IPL during the time period of July 2015 to June 2017. Patients and Methods: All 33 patients were treated with vascular mode of IPL using 560-nm filter every 3 weeks for three to six sessions. Grading of PIE was done by Clinician Erythema Severity Score, and the objective parameters were assessed statistically for improvement using photographs. Adverse effects were noted and followed up. Statistical Analysis: Wilcoxon sign rank test and Pearson's correlation. Results: There was statistically significant reduction in mean erythema score from 2.57 ± 0.66 to 1.21 ± 0.48 following IPL (Z = −5.295, P < 0.001—Wilcoxon sign rank test). Excellent improvement was noted in 11 (33.33%), good in 15 (45.45%), fair in 4 (12.12%), and poor in 3 (9.09%), and the results were consistent on follow-up. Adverse effects included erythema, hyperpigmentation, and hypopigmentation which were all transient and resolved completely in all patients on follow-up. Conclusion: IPL is an effective and safe alternative to otherwise difficult-to-treat acne-induced PIE.
  5,075 509 -
CR Srinivas, C Shanmuga Sekar
May-June 2018, 9(3):175-176
DOI:10.4103/idoj.IDOJ_206_17  PMID:29854637
  3,565 219 -
SkinIndia Quiz 45: Asymptomatic nodular lesion over the neck in an old woman
Suman Patra, Sanjay Singh, Neetu Bhari
May-June 2018, 9(3):214-215
  2,992 171 -
Erasmus syndrome: Association of silicosis and systemic sclerosis
Reena K Sharma, Anjna K Sharma, Anuj Sharma
May-June 2018, 9(3):185-187
DOI:10.4103/idoj.IDOJ_201_17  PMID:29854640
Silicosis is an inflammatory disease of the lung characterized by irreversible lung fibrosis which develops from prolonged pulmonary inhalation and retention of crystalline silica and immune reaction. It mainly appears as an occupational hazard in persons involved in stone-quarrying, mining, and sand blasting. Crystalline silica is not only known to be responsible for silicosis but also for other autoimmune diseases including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA)-Caplan syndrome, systemic sclerosis (SSc), and antineutrophil cytoplasmic antibody (ANCA)-related vasculitis. Erasmus syndrome is the association of silica exposure and subsequent development of SSc. The limited numbers of cases reported in the literature were miners and only sporadically involved in other professionals. Here, we report a case of a 52 -year-old stone cutter who developed silicosis and SSc after 25 years of exposure.
  2,658 264 -
Correlation between disease severity, family income, and quality of life in psoriasis: A study from South India
Preethi B Nayak, Banavasi Shanmukha Girisha, Tonita M Noronha
May-June 2018, 9(3):165-169
DOI:10.4103/idoj.IDOJ_250_17  PMID:29854635
Background: Psoriasis is a common, chronic inflammatory disorder of skin characterized by a long clinical course with exacerbations, remissions, and relapses. The cost of therapy and psychological burden of the disease depends on disease severity. The objective of this study was to assess the quality of life and financial status and to correlate the financial burden of the disease with the severity of psoriasis and quality of life. Materials and Methods: A total of 102 psoriasis patients attending the dermatology outpatient department in our hospital were enrolled in this study. A detailed history and complete physical examination, including, Psoriasis Area and Severity Index (PASI), was done. Their family income was calculated. Quality of life was measured using the dermatology life quality index (DLQI) proposed by Finlay et al. Multiple linear regression was done to identify the predictor variables of quality of life (DLQI). P < 0.05 was considered statistically significant. Results: Among the 102 psoriasis patients 78 were men(76.5%) and 24 were women(23.5%). The mean PASI score was 8.20 ± 6.18 the mean DLQI was 13.01 ± 6.95, and mean family income was INR 15570.10 ± INR 10081.82 per month. There was a significant positive correlation between disease severity and DLQI, and a significant negative correlation between family income and PASI as well as DLQI. Conclusion: The quality of life in psoriasis is affected by both the disease severity and financial status of the patient. The chronic course of psoriasis along with disease severity, in a background of low financial status, impairs the quality of life.
  2,382 356 -
Rhinoscleroma: An unusual presentation
Shashikant Malkud, Pradeep Mahajan
May-June 2018, 9(3):191-193
DOI:10.4103/idoj.IDOJ_134_17  PMID:29854642
Rhinoscleroma is a chronic granulomatous disease caused by Klebsiella rhinoscleromatis. It commonly affects the nasal cavity and nasopharynx, but it can also involve the larynx, trachea, bronchi, middle ear, and orbit. We are reporting a rare presentation of rhinoscleroma in a middle-aged female patient involving the lips and gums.
  2,489 217 -
Serum levels of 25-hydroxyvitamin D in chronic urticaria and its association with disease activity: A case control study
Shagufta Rather, Abid Keen, Peerzada Sajad
May-June 2018, 9(3):170-174
DOI:10.4103/idoj.IDOJ_74_17  PMID:29854636
Aim: To evaluate the relationship between vitamin D levels and chronic spontaneous urticaria (CSU) and compare with healthy age and sex matched controls. Material and Methods: This was a hospital-based cross-sectional study conducted over a period of 1 year, in which 110 patients with CSU were recruited along with an equal number of sex and age-matched healthy controls. For each patient, urticaria activity score (UAS) was calculated and autologous serum skin test (ASST) was performed. Plasma 25-hydroxyvitamin D [25-(OH)D] was analyzed by chemiluminescence method. A deficiency in vitamin D was defined as serum 25-(OH)D concentrations <30 ng/mL. The statistical analysis was carried out by using appropriate statistical tests. Results: The mean serum 25-(OH)D levels of CSU patients was 19.6 ± 6.9 ng/mL, whereas in control group, the mean level was 38.5 ± 6.7, the difference being statistically significant (P < 0.001). A significant negative correlation was found between vitamin D levels and UAS. (P < 0.001). The number of patients with ASST positivity was 44 (40%). Conclusion: The patients with CSU had reduced levels of vitamin D when compared to healthy controls. Furthermore, there was a significant negative correlation between the levels of serum vitamin D and severity of CSU.
  2,098 309 -
Dermoscopy of trichoepithelioma: A clue to diagnosis
Shilpi Sharma, Payal Chauhan, Naveen K Kansal
May-June 2018, 9(3):222-223
DOI:10.4103/idoj.IDOJ_146_17  PMID:29854657
  2,029 216 -
Black dermographism: An uncommon cause of skin discoloration
Vijay Zawar, Shrikant Kumavat, Manoj Pawar
May-June 2018, 9(3):216-217
DOI:10.4103/idoj.IDOJ_228_17  PMID:29854654
  1,836 153 -
Pachydermoperiostosis mimicking acromegaly: A case report
Prerna , Romana Ghosh, Jayanta K Barua, Arup K Das
May-June 2018, 9(3):182-184
DOI:10.4103/idoj.IDOJ_230_17  PMID:29854639
Pachydermoperiostosis is a rare, hereditary disease commonly presenting with digital clubbing, pachyderma, and periosteal hypertrophy. Coarsening of facial features and spade-like enlargement of hands and feet may give rise to a diagnostic dilemma between pachydermoperiostosis and acromegaly. This report highlights a case of a 36-year-old man who presented with broadening of hands and feet, facial skin thickening, and edematous and drooping eyelids for the last 10 years.There was no history of similar presentation in his family. Such clinical presentation in corroboration with normal growth hormone level and prominent radiological abnormalities prompted us to make a diagnosis of pachydermoperiostosis.
  1,648 181 -
A tricky case of hair loss in a child: Trichoscopy saves the day
Sidharth Sonthalia, Abhijeet K Jha, Vishal Gupta, Aimilios Lallas
May-June 2018, 9(3):203-204
DOI:10.4103/idoj.IDOJ_175_17  PMID:29854647
  1,434 161 -
Bacillary angiomatosis in an immunocompetent individual
Balkrishna P Nikam, Natasha Vijayendran, Varsha Jamale, Mohan Kale
May-June 2018, 9(3):205-206
DOI:10.4103/idoj.IDOJ_139_17  PMID:29854648
  1,352 128 -
Myiasis under dermatoscope: The hidden story
Deepak Jakhar, Arvind Misra, Saurabh Dabas
May-June 2018, 9(3):220-221
DOI:10.4103/idoj.IDOJ_258_17  PMID:29854656
  1,231 169 -
Metastatic angiosarcoma of lower extremity
Swagata A Tambe, Chitra S Nayak
May-June 2018, 9(3):177-181
DOI:10.4103/idoj.IDOJ_92_17  PMID:29854638
Angiosarcoma (AS) is an uncommon malignant neoplasm characterized by rapidly proliferating, extensively infiltrating anaplastic cells derived from blood vessels. These are aggressive tumors and tend to recur locally, spread widely with high rate of lymph node and systemic metastases. They are more frequent in skin and soft tissue, head and neck being the most common sites. Here we report a case of metastatic AS affecting lower extremity in an elderly patient on a background of chronic lymphedema due to filariasis (Stewart–Treves syndrome).
  1,120 129 -
Congenital eccrine angiomatous hamartoma: A rare entity revisited
Vibhu Mendiratta, Meenu Malik, Mahima Agrawal, Manjula Jain, Brijnandan Gupta
May-June 2018, 9(3):188-190
DOI:10.4103/idoj.IDOJ_167_17  PMID:29854641
Eccrine angiomatous hamartoma (EAH) is a rare benign malformation characterized by eccrine and vascular components. It usually presents at birth or during early infancy or childhood on lower extremities as a nodule or plaque. We report a case of asymptomatic tumoral swelling over the left leg in a 5-month-old Indian infant since birth. This was diagnosed as EAH on histopathology and confirmed on immunohistochemistry.
  995 153 -
Congenital insensitivity to pain and anhydrosis syndrome
Isa An, Derya Ucmak
May-June 2018, 9(3):211-212
DOI:10.4103/idoj.IDOJ_86_17  PMID:29854651
  1,010 130 -
ADULT (acro–dermato–ungual–lacrimal–tooth) syndrome: A case report from India
Muhammed T Razmi, Tarun Narang, Sanjeev Handa
May-June 2018, 9(3):194-196
DOI:10.4103/idoj.IDOJ_195_17  PMID:29854643
  955 129 -
Dermoscopy of cutaneous mastocytoma
Keshavmurthy A Adya, Arun C Inamadar, Aparna Palit
May-June 2018, 9(3):218-219
DOI:10.4103/idoj.IDOJ_193_17  PMID:29854655
  944 139 -
Coexistence of dermatomyositis and alopecia areata: Insight into pathogenesis
Aashta Gupta, Pooja Arora, Ram K Gautam
May-June 2018, 9(3):199-201
DOI:10.4103/idoj.IDOJ_144_17  PMID:29854645
  880 126 -
Extensive mucocutaneous papillomas in a case of focal dermal hypoplasia
Melna Jose, Shyam Sundar Chaudhary, Shiwesh Anand, Anu Garg
May-June 2018, 9(3):208-210
DOI:10.4103/idoj.IDOJ_145_17  PMID:29854650
  793 110 -
Crusted scabies in systemic sclerosis with plasma cell dyscrasia
Balkrishna P Nikam, Shraddha J Patil, Varsha Jamale, Mohan Kale
May-June 2018, 9(3):197-198
DOI:10.4103/idoj.IDOJ_212_17  PMID:29854644
  732 96 -
Cytomorphological diagnosis of isolated cutaneous aspergillosis in an immunocompetent host
Manjari Kishore, Prajwala Gupta, Minakshi Bhardwaj
May-June 2018, 9(3):206-208
DOI:10.4103/idoj.IDOJ_168_17  PMID:29854649
  686 102 -
Herpes zoster: Hand dominance the missing link to unilaterality?
Sandeep Arora, Pradeep Patil, Gulhima Arora, Rakesh Mishra
May-June 2018, 9(3):212-213
DOI:10.4103/idoj.IDOJ_15_17  PMID:29854652
  627 92 -
Unsuspected amelanotic melanoma in an elephantiasis foot
Sangita Bohara, Ajay Kumar, Sunil K Gupta, Vivek Gupta
May-June 2018, 9(3):202-203
DOI:10.4103/idoj.IDOJ_251_17  PMID:29854646
  555 97 -
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