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  Indian J Med Microbiol
 

Figure 3: Aquagenic keratoderma (AK) pathogenesis. Normal epidermis (left), AK skinafter water immersions (right). The secretory coil in AK shows an increased expression of aquaporin (AQP) 5. Water immersions and secretion of hyperosmotic sweat activates osmosensitive transient vanilloid receptor type-1, increasing the Ca2+-influx, and AQP 10. Skin wrinkling is further attenuated by small sympathetic fiber activity

Figure 3: Aquagenic keratoderma (AK) pathogenesis. Normal epidermis (left), AK skinafter water immersions (right). The secretory coil in AK shows an increased expression of aquaporin (AQP) 5. Water immersions and secretion of hyperosmotic sweat activates osmosensitive transient vanilloid receptor type-1, increasing the Ca2+-influx, and AQP 10. Skin wrinkling is further attenuated by small sympathetic fiber activity