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  Indian J Med Microbiol
 

Figure 1: Steps that determine clinical use of Antifungal drugs including itraconazole. The Laboratory data is based on minimal inhibitory concentration (MIC), Minimal fungicidal depend on the concentration (MFC)/MIC ratio and checkerboard studies. The serum levels bioavailability which should be correlated with skin levels of the drug. The skin levels should be higher than the MIC levels for consistent with clinical efficacy serum. Superbioavailable Itraconazole would lead to consistently uniform levels which are higher than conventional itraconazole and the skin levels enhanced than the prevalent MIC levels in India this should translate into clinical efficacy

Figure 1: Steps that determine clinical use of Antifungal drugs including itraconazole. The Laboratory data is based on minimal inhibitory concentration (MIC), Minimal fungicidal depend on the concentration (MFC)/MIC ratio and checkerboard studies. The serum levels bioavailability which should be correlated with skin levels of the drug. The skin levels should be higher than the MIC levels for consistent with clinical efficacy serum. Superbioavailable Itraconazole would lead to consistently uniform levels which are higher than conventional itraconazole and the skin levels enhanced than the prevalent MIC levels in India this should translate into clinical efficacy